Clinical profiling of skin microbiome and metabolome during re-epithelialization

• Published in: Scientific reports Vol. 15; no. 1; pp. 22282 - 18
• Main Authors: Bianchi, P., Jacques, C., Theunis, J., Jamin, E. L., Orlandi, C., Cauhape, L., Alvarez-Georges, S., Alves, A., Simcic-Mori, A., Lauze, C., Gravier, E., Carballido, F., Ribet, V., Bessou-Touya, S., Duplan, H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Portfolio
• Subjects: 631/1647/2017; 631/1647/320; 631/80; 692/53/2423; Adult; Bacteria - classification; Bacteria - genetics; Clinical study; Female; Humanities and Social Sciences; Humans; Male; Metabolome; Metabolomics - methods; Microbiota; Middle Aged; multidisciplinary; Re-Epithelialization; Rhealba oat concentrate; RNA, Ribosomal, 16S - genetics; Science; Science (multidisciplinary); Skin - metabolism; Skin - microbiology; Skin metabolome; Skin Microbiome; Sodium hyaluronate; Wound Healing; Formula; Skin metabolome; Wound healing; Sodium hyaluronate; Rhealba oat concentrate; Skin microbiome; Clinical study

We investigated changes in skin microbiome and metabolome linked to wound healing and how these are affected by a formula known to improve re-epithelialization. In a clinical study with 21 subjects, forearm lesions were induced by epidermal laser ablation. The areas were left untreated or treated wi...