MiR-760 overexpression promotes proliferation in ovarian cancer by downregulation of PHLPP2 expression

• Published in: Gynecologic oncology Vol. 143; no. 3; pp. 655 - 663
• Main Authors: Liao, Yanbin, Deng, Yalan, Liu, Jun, Ye, Zhanying, You, Zeshan, Yao, Shuzhong, He, Shanyang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016
• Subjects: Blotting, Western; Carcinogenesis - genetics; Cell Line, Tumor; Cell Proliferation - genetics; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hematology, Oncology and Palliative Medicine; Humans; In Vitro Techniques; MicroRNAs - genetics; miR-760; Obstetrics and Gynecology; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; PHLPP2; Phosphoprotein Phosphatases - metabolism; Proliferation; Real-Time Polymerase Chain Reaction; Up-Regulation; PHLPP2; Proliferation; miR-760; Ovarian cancer

Ovarian cancer is one of the most lethal gynecologic malignancies worldwide and with poor prognosis and survival rate in women. Identifying sensitive and specific molecular in carcinogenesis may improve diagnostic and therapeutic strategies for this malignancy and achieve a better clinical outcome....