Ferroptosis in acute kidney injury following crush syndrome: A novel target for treatment

• Published in: Journal of advanced research Vol. 54; pp. 211 - 222
• Main Authors: Qiao, Ou, Wang, Xinyue, Wang, Yuru, Li, Ning, Gong, Yanhua
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier B.V 01.12.2023; Elsevier
• Subjects: Acute kidney injury; Acute Kidney Injury - etiology; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Cell Death; Crush syndrome; Crush Syndrome - complications; Crush Syndrome - pathology; Drug development; Ferroptosis; Humans; Myoglobin; Systemic inflammatory responses; Myoglobin; Systemic inflammatory responses; Ferroptosis; Crush syndrome; Drug development; Acute kidney injury

[Display omitted] •Inhibiting ferroptosis could alleviate acute kidney injury following crush syndrome.•Iron overload produced by myoglobin degradation is a risk factor for ferroptosis.•HMGB1 and souble-stranded DNA trigger ferroptosis via multiple signaling pathways.•Crosstalk between inflammation...