The impact of "early" versus "late" initiation of renal replacement therapy in critical care patients with acute kidney injury: a systematic review and evidence synthesis

• Published in: Critical care (London, England) Vol. 20; no. 1; p. 122
• Main Authors: Wierstra, Benjamin T, Kadri, Sameer, Alomar, Soha, Burbano, Ximena, Barrisford, Glen W, Kao, Raymond L C
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.05.2016; BioMed Central
• Subjects: Acute Kidney Injury - prevention & control; Acute Kidney Injury - therapy; Acute renal failure; Adult; Care and treatment; Complications and side effects; Critical Illness - nursing; Critical Illness - therapy; Health aspects; Humans; Intensive Care Units; Length of Stay; Prospective Studies; Renal Replacement Therapy - mortality; Renal Replacement Therapy - nursing; Retrospective Studies; Services; Early; Late; Renal replacement therapy (RRT); Intensive care units (ICUs); Acute kidney injury (AKI); Meta-analysis

The optimal timing of initiating renal replacement therapy (RRT) in critical illness complicated by acute kidney injury (AKI) is not clearly established. Trials completed on this topic have been marked by contradictory findings as well as quality and heterogeneity issues. Our goal was to perform a s...