VEGF and ELAVL1/HuR protein levels are increased in dry and wet AMD patients. A new tile in the pathophysiologic mechanisms underlying RPE degeneration? - Bresciani, Giorgia; Manai, Federico; Felszeghy, Szabolcs; Smedowski, Adrian; Kaarniranta, Kai; Amadio, Marialaura (Pharmacological research, 2024)
Keywords: Aged; Aged, 80 and over; AMD; Animals; ELAV-Like Protein 1 - genetics; ELAV-Like Protein 1 - metabolism; Female; Geographic Atrophy - metabolism; Humans; HuR; Macular Degeneration - metabolism; Macular Degeneration - pathology; Macular Degeneration - physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nrf2; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Retina; Retinal Pigment Epithelium - metabolism; RPE; Vascular Endothelial Growth Factor A - metabolism; VEGF; Wet Macular Degeneration - genetics; Wet Macular Degeneration - metabolism; AMD; Retina; HuR; Nrf2; VEGF; RPE