Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 32; no. 7; pp. 1490 - 1503
• Main Authors: Czéh, Boldizsár, Müller-Keuker, Jeanine I H, Rygula, Rafal, Abumaria, Nashat, Hiemke, Christoph, Domenici, Enrico, Fuchs, Eberhard
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2007; Nature Publishing Group
• Subjects: Animals; Antidepressants; Asymmetry; Behavioral Sciences; Biological Psychology; Body Weight - drug effects; Body Weight - physiology; Brain research; Bromodeoxyuridine; Cell Count; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cell growth; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell Survival - physiology; Chronic Disease; Dentate Gyrus - drug effects; Dentate Gyrus - physiopathology; Depressive Disorder - drug therapy; Depressive Disorder - physiopathology; Experiments; Fluoxetine - pharmacology; Functional Laterality - drug effects; Functional Laterality - physiology; Male; Medicine; Medicine & Public Health; Neurobiology; Neurogenesis; Neuroglia - drug effects; Neuroglia - metabolism; Neurons - drug effects; Neurons - metabolism; Neurosciences; Organ Size - drug effects; Organ Size - physiology; original-article; Pharmacotherapy; Prefrontal Cortex - drug effects; Prefrontal Cortex - pathology; Prefrontal Cortex - physiopathology; Psychiatry; Rats; Rats, Wistar; Serotonin Uptake Inhibitors - pharmacology; Social Behavior; Stem Cells - drug effects; Stem Cells - metabolism; Stress; Stress, Psychological - drug therapy; Stress, Psychological - physiopathology; Germany; neurogenesis; stereology; NG2; hippocampus; glia; cell number

Profound neuroplastic changes have been demonstrated in various limbic structures after chronic stress exposure and antidepressant treatment in animal models of mood disorders. Here, we examined in rats the effect of chronic social stress and concomitant antidepressant treatment on cell proliferatio...