Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome

• Published in: The Journal of biological chemistry Vol. 286; no. 4; pp. 3018 - 3032
• Main Authors: Merz, Andreas, Long, Gang, Hiet, Marie-Sophie, Brügger, Britta, Chlanda, Petr, Andre, Patrice, Wieland, Felix, Krijnse-Locker, Jacomine, Bartenschlager, Ralf
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.01.2011; American Society for Biochemistry and Molecular Biology
• Subjects: Apolipoproteins; Cell Line; Cholesterol; Epitopes - chemistry; Epitopes - genetics; Epitopes - metabolism; Glycoproteins - chemistry; Glycoproteins - genetics; Glycoproteins - metabolism; Hepacivirus - chemistry; Hepacivirus - genetics; Hepacivirus - metabolism; Hepatitis Virus; Humans; Lipid; Lipo-viro-particles; Lipoprotein; Low Density Lipoprotein (LDL); Membrane Lipids - analysis; Membrane Lipids - genetics; Membrane Lipids - metabolism; Microbiology; RNA Viruses; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Viral Envelope Proteins - metabolism; Virus; Virus Structure; Virus Structure; Virus; Low Density Lipoprotein (LDL); Hepatitis Virus; Lipo-viro-particles; RNA Viruses; Lipoprotein; Apolipoproteins; Cholesterol; Lipid

A hallmark of hepatitis C virus (HCV) particles is their association with host cell lipids, most notably lipoprotein components. It is thought that this property accounts for the low density of virus particles and their large heterogeneity. However, the composition of infectious virions and their bi...