Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data

• Published in: Frontiers in nutrition (Lausanne) Vol. 10; p. 1015046
• Main Authors: Fu, Liwan, Wang, Yuquan, Hu, Yue-Qing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.03.2023
• Subjects: genome-wide association studies; liver enzymes; Mendelian randomization; non-alcoholic liver disease; Nutrition; vitamin B12 concentrations; liver enzymes; non-alcoholic liver disease; Mendelian randomization; genome-wide association studies; vitamin B12 concentrations

Many observational studies evaluate the association between vitamin B12 and non-alcoholic fatty liver disease (NAFLD). However, the causality of this association remains uncertain, especially in European populations. We conducted a bidirectional Mendelian randomization study to explore the associati...