Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting

Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotypin...

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Published inCancers Vol. 15; no. 19; p. 4729
Main Authors Nishizawa, Daisuke, Morino, Ryozo, Inoue, Rie, Ohka, Seii, Kasai, Shinya, Hasegawa, Junko, Ebata, Yuko, Nakayama, Kyoko, Sumikura, Hiroyuki, Hayashida, Masakazu, Yokota, Miyuki, Ikeda, Kazutaka
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 26.09.2023
MDPI
Subjects
Anesthesia
Body mass index
Cancer
CNTN5 gene
Deoxyribonucleic acid
DNA
Dopamine
Droperidol
Drug dosages
Elective surgery
Females
Gender
General anesthesia
Genes
Genetic aspects
Genetic diversity
Genetic factors
Genome-wide association studies
Genomes
Genomics
Genotyping
Gynecological surgery
Hospitals
Informed consent
Laparoscopy
Medicine, Preventive
Motion sickness
Narcotics
Nausea
Patients
Postoperative period
Preventive health services
Propofol
Remifentanil
Review boards
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Surgery
Vomiting
Japan
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Abstract Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV.
AbstractList Postoperative nausea and vomiting (PONV) is experienced by approximately 30% of patients who undergo general anesthesia. However, many genetic factors involved in the vulnerability to PONV remain unidentified. The aim of our genome-wide association study (GWAS) was to comprehensively explore genetic variations associated with PONV. We identified several single-nucleotide polymorphisms (SNPs) that may possibly be associated with the frequency of nausea and vomiting, of which the most potent were the rs2776262, rs140703637, rs7212072, rs12444143, rs45574836, and rs1752136 SNPs. These results indicate that these SNPs in the LOC100506403, CNTN5, SHISA6, RBFOX1, ATP8B3, and LOC105370198 gene regions could serve as markers that predict the vulnerability to PONV.
Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV.
Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV.Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV.
Postoperative nausea and vomiting (PONV) is experienced by approximately 30% of patients who undergo general anesthesia. However, many genetic factors involved in the vulnerability to PONV remain unidentified. The aim of our genome-wide association study (GWAS) was to comprehensively explore genetic variations associated with PONV. We identified several single-nucleotide polymorphisms (SNPs) that may possibly be associated with the frequency of nausea and vomiting, of which the most potent were the rs2776262, rs140703637, rs7212072, rs12444143, rs45574836, and rs1752136 SNPs. These results indicate that these SNPs in the LOC100506403, CNTN5, SHISA6, RBFOX1, ATP8B3, and LOC105370198 gene regions could serve as markers that predict the vulnerability to PONV. Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV.
Simple SummaryPostoperative nausea and vomiting (PONV) is experienced by approximately 30% of patients who undergo general anesthesia. However, many genetic factors involved in the vulnerability to PONV remain unidentified. The aim of our genome-wide association study (GWAS) was to comprehensively explore genetic variations associated with PONV. We identified several single-nucleotide polymorphisms (SNPs) that may possibly be associated with the frequency of nausea and vomiting, of which the most potent were the rs2776262, rs140703637, rs7212072, rs12444143, rs45574836, and rs1752136 SNPs. These results indicate that these SNPs in the LOC100506403, CNTN5, SHISA6, RBFOX1, ATP8B3, and LOC105370198 gene regions could serve as markers that predict the vulnerability to PONV.AbstractConsiderable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the LOC100506403 and CNTN5 gene regions, respectively, were significantly associated with the frequency of nausea. In another GWAS conducted only on patients who received propofol, rs7212072 and rs12444143 SNPs in the SHISA6 and RBFOX1 gene regions, respectively, were significantly associated with the frequency of nausea as well as the rs2776262 SNP, and the rs45574836 and rs1752136 SNPs in the ATP8B3 and LOC105370198 gene regions, respectively, were significantly associated with vomiting. Among these SNPs, clinical and SNP data were available for the rs45574836 SNP in independent subjects who underwent laparoscopic gynecological surgery, and the association was replicated in these subjects. These results indicate that these SNPs could serve as markers that predict the vulnerability to PONV. Our findings may provide valuable information for achieving satisfactory prophylactic treatment for PONV.
Audience Academic
Author Nishizawa, Daisuke
Ikeda, Kazutaka
Ebata, Yuko
Nakayama, Kyoko
Morino, Ryozo
Ohka, Seii
Hasegawa, Junko
Kasai, Shinya
Hayashida, Masakazu
Inoue, Rie
Yokota, Miyuki
Sumikura, Hiroyuki
AuthorAffiliation 4 Department of Anesthesiology, Cancer Institute Hospital, Tokyo 135-8550, Japan
1 Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan; nishizawa-ds@igakuken.or.jp (D.N.)
3 Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo 113-8421, Japan
5 Department of Anesthesiology, East Hokkaido Hospital, Kushiro 085-0036, Japan
2 Division of Anesthesiology, Koujinkai Daiichi Hospital, Tokyo 125-0041, Japan
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CitedBy_id crossref_primary_10_3390_ijms25168845
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Snippet Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association...
Postoperative nausea and vomiting (PONV) is experienced by approximately 30% of patients who undergo general anesthesia. However, many genetic factors involved...
Simple SummaryPostoperative nausea and vomiting (PONV) is experienced by approximately 30% of patients who undergo general anesthesia. However, many genetic...
SourceID pubmedcentral
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SourceType Open Access Repository
Aggregation Database
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StartPage 4729
SubjectTerms Anesthesia
Body mass index
Cancer
CNTN5 gene
Deoxyribonucleic acid
DNA
Dopamine
Droperidol
Drug dosages
Elective surgery
Females
Gender
General anesthesia
Genes
Genetic aspects
Genetic diversity
Genetic factors
Genome-wide association studies
Genomes
Genomics
Genotyping
Gynecological surgery
Hospitals
Informed consent
Laparoscopy
Medicine, Preventive
Motion sickness
Narcotics
Nausea
Patients
Postoperative period
Preventive health services
Propofol
Remifentanil
Review boards
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Surgery
Vomiting
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Title Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting
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https://pubmed.ncbi.nlm.nih.gov/PMC10571790
Volume 15
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