High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells

• Published in: Cell metabolism Vol. 29; no. 6; pp. 1334 - 1349.e10
• Main Authors: Hu, Chun-Mei, Tien, Sui-Chih, Hsieh, Ping-Kun, Jeng, Yung-Ming, Chang, Ming-Chu, Chang, Yu-Ting, Chen, Yi-Ju, Chen, Yu-Ju, Lee, Eva Y.-H.P., Lee, Wen-Hwa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2019
• Subjects: high glucose; KRAS mutation; nucleotide imbalance; O-GlcNAcylation; PFK; RNR; RRM1; KRAS mutation; RRM1; high glucose; PFK; RNR; nucleotide imbalance; O-GlcNAcylation
• ISSN: 1550-4131; 1932-7420; 1932-7420
• DOI: 10.1016/j.cmet.2019.02.005

KRAS mutations are the earliest events found in approximately 90% of pancreatic ductal adenocarcinomas (PDACs). However, little is known as to why KRAS mutations preferentially occur in PDACs and what processes/factors generate these mutations. While abnormal carbohydrate metabolism is associated wi...