Urethral large B-cell urethral lymphoma: A case report and literature review

We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weig...

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Published inTaiwanese journal of obstetrics & gynecology Vol. 60; no. 5; pp. 920 - 923
Main Authors Chien, Chih-Wei, Lee, Cheng-Kai, Wang, Po-Nan, Chien, Pei-Chun, Hsu, Yu-Ying, Tseng, Ling-Hong
Format Journal Article
LanguageEnglish
Published China (Republic : 1949- ) Elsevier B.V 01.09.2021
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Abstract We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weight loss or unexplained fatigue. There were no enlarged lymph nodes or palpable liver or spleen upon physical examination. Pelvic examination revealed an ulcerative lesion arising from the posterior wall of the urethral meatus. Cystourethroscopy showed no bladder involvement. Surgical excision of the urethral ulcer was done and immunohistochemical report showed a diffuse large B-cell lymphoma. Bone marrow needle biopsy and computed tomography were done and the diagnosis of primary diffuse large B-cell urethral lymphoma stage IEA was made. She underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab and was free of disease for 51 months. This report of urethral lymphoma was presented as a non-healing ulcer initially, which was totally different previous reports, presenting with bleeding, either vaginal or urinary, urinary frequency, dysuria, urine retention and self-perceived mass, suggesting that unhealed ulcer on the perineal area should be promptly evaluated and avoidance of unnecessary delayed therapy for possible curable disease.
AbstractList Objective: We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. Case Report: A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weight loss or unexplained fatigue. There were no enlarged lymph nodes or palpable liver or spleen upon physical examination. Pelvic examination revealed an ulcerative lesion arising from the posterior wall of the urethral meatus. Cystourethroscopy showed no bladder involvement. Surgical excision of the urethral ulcer was done and immunohistochemical report showed a diffuse large B-cell lymphoma. Bone marrow needle biopsy and computed tomography were done and the diagnosis of primary diffuse large B-cell urethral lymphoma stage IEA was made. She underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab and was free of disease for 51 months. Conclusion: This report of urethral lymphoma was presented as a non-healing ulcer initially, which was totally different previous reports, presenting with bleeding, either vaginal or urinary, urinary frequency, dysuria, urine retention and self-perceived mass, suggesting that unhealed ulcer on the perineal area should be promptly evaluated and avoidance of unnecessary delayed therapy for possible curable disease.
We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weight loss or unexplained fatigue. There were no enlarged lymph nodes or palpable liver or spleen upon physical examination. Pelvic examination revealed an ulcerative lesion arising from the posterior wall of the urethral meatus. Cystourethroscopy showed no bladder involvement. Surgical excision of the urethral ulcer was done and immunohistochemical report showed a diffuse large B-cell lymphoma. Bone marrow needle biopsy and computed tomography were done and the diagnosis of primary diffuse large B-cell urethral lymphoma stage IEA was made. She underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab and was free of disease for 51 months. This report of urethral lymphoma was presented as a non-healing ulcer initially, which was totally different previous reports, presenting with bleeding, either vaginal or urinary, urinary frequency, dysuria, urine retention and self-perceived mass, suggesting that unhealed ulcer on the perineal area should be promptly evaluated and avoidance of unnecessary delayed therapy for possible curable disease.
Author Wang, Po-Nan
Lee, Cheng-Kai
Chien, Chih-Wei
Hsu, Yu-Ying
Tseng, Ling-Hong
Chien, Pei-Chun
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Issue 5
Keywords Urethral lymphoma
Non-healing urethra
Urethral Non-Hodgkin's lymphoma
Language English
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Snippet We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. A 68-year-old woman presented with a non-healing...
Objective: We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. Case Report: A 68-year-old woman...
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SubjectTerms Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biopsy
Cyclophosphamide - administration & dosage
Cyclophosphamide - therapeutic use
Female
Humans
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - drug therapy
Lymphoma, Large B-Cell, Diffuse - pathology
Non-healing urethra
Ulcer - etiology
Urethra - pathology
Urethral lymphoma
Urethral Neoplasms - diagnosis
Urethral Neoplasms - drug therapy
Urethral Neoplasms - pathology
Urethral Non-Hodgkin's lymphoma
Vincristine - administration & dosage
Vincristine - therapeutic use
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Title Urethral large B-cell urethral lymphoma: A case report and literature review
URI https://dx.doi.org/10.1016/j.tjog.2021.07.025
https://www.ncbi.nlm.nih.gov/pubmed/34507675
https://doaj.org/article/0488a0dc479c4c6a856fcc2e3d475140
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