Urethral large B-cell urethral lymphoma: A case report and literature review
We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weig...
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Published in | Taiwanese journal of obstetrics & gynecology Vol. 60; no. 5; pp. 920 - 923 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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China (Republic : 1949- )
Elsevier B.V
01.09.2021
Elsevier |
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Abstract | We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer.
A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weight loss or unexplained fatigue. There were no enlarged lymph nodes or palpable liver or spleen upon physical examination. Pelvic examination revealed an ulcerative lesion arising from the posterior wall of the urethral meatus. Cystourethroscopy showed no bladder involvement. Surgical excision of the urethral ulcer was done and immunohistochemical report showed a diffuse large B-cell lymphoma. Bone marrow needle biopsy and computed tomography were done and the diagnosis of primary diffuse large B-cell urethral lymphoma stage IEA was made. She underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab and was free of disease for 51 months.
This report of urethral lymphoma was presented as a non-healing ulcer initially, which was totally different previous reports, presenting with bleeding, either vaginal or urinary, urinary frequency, dysuria, urine retention and self-perceived mass, suggesting that unhealed ulcer on the perineal area should be promptly evaluated and avoidance of unnecessary delayed therapy for possible curable disease. |
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AbstractList | Objective: We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. Case Report: A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weight loss or unexplained fatigue. There were no enlarged lymph nodes or palpable liver or spleen upon physical examination. Pelvic examination revealed an ulcerative lesion arising from the posterior wall of the urethral meatus. Cystourethroscopy showed no bladder involvement. Surgical excision of the urethral ulcer was done and immunohistochemical report showed a diffuse large B-cell lymphoma. Bone marrow needle biopsy and computed tomography were done and the diagnosis of primary diffuse large B-cell urethral lymphoma stage IEA was made. She underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab and was free of disease for 51 months. Conclusion: This report of urethral lymphoma was presented as a non-healing ulcer initially, which was totally different previous reports, presenting with bleeding, either vaginal or urinary, urinary frequency, dysuria, urine retention and self-perceived mass, suggesting that unhealed ulcer on the perineal area should be promptly evaluated and avoidance of unnecessary delayed therapy for possible curable disease. We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. A 68-year-old woman presented with a non-healing urethral ulcer accompanied with vulvar pruritus, which failed to medical treatment. Her medical history was unremarkable, lacking fever, weight loss or unexplained fatigue. There were no enlarged lymph nodes or palpable liver or spleen upon physical examination. Pelvic examination revealed an ulcerative lesion arising from the posterior wall of the urethral meatus. Cystourethroscopy showed no bladder involvement. Surgical excision of the urethral ulcer was done and immunohistochemical report showed a diffuse large B-cell lymphoma. Bone marrow needle biopsy and computed tomography were done and the diagnosis of primary diffuse large B-cell urethral lymphoma stage IEA was made. She underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab and was free of disease for 51 months. This report of urethral lymphoma was presented as a non-healing ulcer initially, which was totally different previous reports, presenting with bleeding, either vaginal or urinary, urinary frequency, dysuria, urine retention and self-perceived mass, suggesting that unhealed ulcer on the perineal area should be promptly evaluated and avoidance of unnecessary delayed therapy for possible curable disease. |
Author | Wang, Po-Nan Lee, Cheng-Kai Chien, Chih-Wei Hsu, Yu-Ying Tseng, Ling-Hong Chien, Pei-Chun |
Author_xml | – sequence: 1 givenname: Chih-Wei surname: Chien fullname: Chien, Chih-Wei organization: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Lin-Kou Branch, Taiwan – sequence: 2 givenname: Cheng-Kai surname: Lee fullname: Lee, Cheng-Kai organization: Department of Obstetrics and Gynecology, Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan – sequence: 3 givenname: Po-Nan surname: Wang fullname: Wang, Po-Nan organization: Department of Hematology and Lymphoma, Chang Gung Memorial Hospital Lin-Kou Branch, Taiwan – sequence: 4 givenname: Pei-Chun surname: Chien fullname: Chien, Pei-Chun organization: Department of Obstetrics and Gynecology, Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan – sequence: 5 givenname: Yu-Ying surname: Hsu fullname: Hsu, Yu-Ying organization: Department of Obstetrics and Gynecology, Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan – sequence: 6 givenname: Ling-Hong surname: Tseng fullname: Tseng, Ling-Hong email: 3g7330@yahoo.com.tw organization: Department of Obstetrics and Gynecology, Taoyuan General Hospital, Ministry of Health and Welfare, Taiwan |
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CitedBy_id | crossref_primary_10_1016_j_humpath_2023_02_011 crossref_primary_10_1097_RLU_0000000000004720 crossref_primary_10_1016_j_humpath_2022_08_003 crossref_primary_10_1016_j_eucr_2023_102594 |
Cites_doi | 10.1006/gyno.1993.1232 10.1111/j.1442-2042.1994.tb00052.x 10.1016/j.urology.2007.08.015 10.1001/jama.1966.03110110059014 10.1007/BF02550554 10.4081/aiua.2019.1.49 10.1016/0090-4295(84)90173-0 10.1097/00007611-197805000-00020 10.1159/000333357 10.1111/j.1365-2559.2005.02033.x 10.1111/iju.12507 10.2214/ajr.181.2.1810600 10.1016/0090-4295(93)90287-K 10.1111/j.1464-410X.1990.tb14721.x 10.1080/00365599.1992.11690440 10.1078/0344-0338-00304 10.1111/j.1365-2559.1994.tb00570.x 10.1016/0090-8258(89)90023-1 10.1016/0090-4295(93)90630-S 10.1023/A:1019544617945 |
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Keywords | Urethral lymphoma Non-healing urethra Urethral Non-Hodgkin's lymphoma |
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Snippet | We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer.
A 68-year-old woman presented with a non-healing... Objective: We report a case of diffuse large B-cell urethral lymphoma initial presenting with non-healing urethra ulcer. Case Report: A 68-year-old woman... |
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SubjectTerms | Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Cyclophosphamide - administration & dosage Cyclophosphamide - therapeutic use Female Humans Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - pathology Non-healing urethra Ulcer - etiology Urethra - pathology Urethral lymphoma Urethral Neoplasms - diagnosis Urethral Neoplasms - drug therapy Urethral Neoplasms - pathology Urethral Non-Hodgkin's lymphoma Vincristine - administration & dosage Vincristine - therapeutic use |
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Title | Urethral large B-cell urethral lymphoma: A case report and literature review |
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