Histone arginine methyltransferase CARM1 selective inhibitor TP-064 induces apoptosis in endometrial cancer

• Published in: Biochemical and biophysical research communications Vol. 601; pp. 123 - 128
• Main Authors: Inoue, Futaba, Sone, Kenbun, Toyohara, Yusuke, Tanimoto, Saki, Takahashi, Yu, Kusakabe, Misako, Kukita, Asako, Honjoh, Harunori, Nishijima, Akira, Taguchi, Ayumi, Miyamoto, Yuichiro, Tanikawa, Michihiro, Iriyama, Takayuki, Uchino, Mayuyo-mori, Tsuruga, Tetsushi, Wada-Hiraike, Osamu, Oda, Katsutoshi, Osuga, Yutaka
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.04.2022
• Subjects: Apoptosis; Arginine - metabolism; CARD Signaling Adaptor Proteins; CARM1; Endometrial cancer; Endometrial Neoplasms - drug therapy; Endometrial Neoplasms - genetics; Female; Guanylate Cyclase; Histone arginine methyltransferase; Histones - metabolism; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Protein-Arginine N-Methyltransferases - genetics; Protein-Arginine N-Methyltransferases - metabolism; TP-064; Histone arginine methyltransferase; Endometrial cancer; CARM1; PRMT; TP-064; EC; HMT; Apoptosis

Histone modification is the key epigenetic mechanism that regulates gene expression. Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that catalyzes dimethylation of histone H3 (H3R17) at arginine 17. Lately, it has been suggested that CARM1 is associated...