Fibrinogen and tumors

Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentua...

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Published inFrontiers in oncology Vol. 14; p. 1393599
Main Authors Wu, Xinyuan, Yu, Xiaomin, Chen, Cheng, Chen, Chenlu, Wang, Yuxin, Su, Dongyan, Zhu, Liqing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.05.2024
Subjects
angiogenesis
fibrinogen
metastasis
molecular pathway
Oncology
pro-inflammatory
tumor
molecular pathway
fibrinogen
metastasis
angiogenesis
tumor
pro-inflammatory
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Abstract Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.
AbstractList Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.
Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.
Author Zhu, Liqing
Su, Dongyan
Yu, Xiaomin
Chen, Cheng
Chen, Chenlu
Wang, Yuxin
Wu, Xinyuan
AuthorAffiliation 3 Department of Hematology, Wenzhou Key Laboratory of Hematology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang , China
2 Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang , China
1 School & Hospital of Stomatology, Wenzhou Medical University , Wenzhou, Zhejiang , China
4 Department of Clinical Laboratory, Peking University Cancer Hospital and Institute , Beijing , China
AuthorAffiliation_xml – name: 2 Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang , China
– name: 4 Department of Clinical Laboratory, Peking University Cancer Hospital and Institute , Beijing , China
– name: 1 School & Hospital of Stomatology, Wenzhou Medical University , Wenzhou, Zhejiang , China
– name: 3 Department of Hematology, Wenzhou Key Laboratory of Hematology, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang , China
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  surname: Wu
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– sequence: 2
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Keywords molecular pathway
fibrinogen
metastasis
angiogenesis
tumor
pro-inflammatory
Language English
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Edited by: Robson Q. Monteiro, Federal University of Rio de Janeiro, Brazil
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Snippet Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor...
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SubjectTerms angiogenesis
fibrinogen
metastasis
molecular pathway
Oncology
pro-inflammatory
tumor
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Title Fibrinogen and tumors
URI https://www.ncbi.nlm.nih.gov/pubmed/38779081
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Volume 14
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