High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

• Published in: Respiratory research Vol. 17; no. 1; p. 125
• Main Authors: Sand, Jannie M. B., Leeming, Diana J., Byrjalsen, Inger, Bihlet, Asger R., Lange, Peter, Tal-Singer, Ruth, Miller, Bruce E., Karsdal, Morten A., Vestbo, Jørgen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.10.2016; BioMed Central
• Subjects: Age Factors; Aged; Airway Remodeling; Biomarkers - blood; Case-Control Studies; Collagen; Collagen - blood; Collagen Type IV - blood; Disease Progression; Dyspnea - blood; Dyspnea - mortality; Dyspnea - physiopathology; Exercise Tolerance; Extracellular matrix; Extracellular Matrix - metabolism; Female; Genetic aspects; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Lung - metabolism; Lung - physiopathology; Lung diseases, Obstructive; Male; Middle Aged; Peptide Fragments - blood; Physiological aspects; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive - blood; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - mortality; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Emphysema - blood; Pulmonary Emphysema - mortality; Pulmonary Emphysema - physiopathology; Risk Factors; Smoking - adverse effects; Smoking - mortality; Time Factors; Up-Regulation; Denmark; United Kingdom; Biomarker; Collagen; Elastin; Mortality; Extracellular matrix; Remodeling; Prognostic; COPD
• ISSN: 1465-993X; 1465-9921; 1465-993X
• DOI: 10.1186/s12931-016-0440-6

There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated with mortality in COPD an...