Effective methylprednisolone dose in experimental crescentic glomerulonephritis

• Published in: American journal of kidney diseases Vol. 37; no. 2; p. 411
• Main Authors: Ou, Z L, Nakayama, K, Natori, Y, Doi, N, Saito, T
• Format: Journal Article
• Language: English
• Published: United States 01.02.2001
• Subjects: Animals; Chemokines - genetics; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Glomerulonephritis - drug therapy; Glomerulonephritis - etiology; Glucocorticoids - administration & dosage; Kidney Glomerulus - cytology; Kidney Glomerulus - immunology; Kidney Glomerulus - metabolism; Leukocytes; Methylprednisolone - administration & dosage; Proteinuria; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism

Pulse methylprednisolone (MP) therapy improves the prognosis of crescentic glomerulonephritis, but the optimal dose is uncertain. We reported previously that treatment with MP at a dose of 30 mg/kg reduces glomerular crescents and infiltrating mononuclear cells and ameliorates the clinical abnormali...