Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial)

• Published in: Scientific reports Vol. 15; no. 1; pp. 21059 - 15
• Main Authors: Borsky, Pavel, Holmannova, Drahomira, Parova, Helena, Horvath, Steve, Sramek, Petr, Brooke, Robert T., Milciute, Milda, Gordevicius, Juozas, Fiala, Zdenek, Andrys, Ctirad, Kremlacek, Jan, Rehacek, Vit, Baranova, Ivana, Matyasovska, Natalia, Borska, Lenka
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Portfolio
• Subjects: 631/208/176/1988; 692/53/2423; Adult; Aging; Aging - blood; Aging - genetics; Biomarkers; Biomarkers - blood; Cross-Over Studies; Epigenesis, Genetic; Epigenetic clock; Female; Humanities and Social Sciences; Humans; Male; Middle Aged; multidisciplinary; Plasmapheresis; Plasmapheresis - adverse effects; Plasmapheresis - methods; Science; Science (multidisciplinary); Aging; Biomarkers; Epigenetic clock; Plasmapheresis

Plasmapheresis is a medical procedure that separates plasma from blood cells, potentially removing pro-aging factors from circulation. Some studies suggest it may have rejuvenating effects by altering biomarkers of aging, but evidence on its impact on epigenetic aging in humans is limited. This stud...