5-aminolevulinic acid, fluorescein sodium, and indocyanine green for glioma margin detection: analysis of operating wide-field and confocal microscopy in glioma models of various grades

• Published in: Frontiers in oncology Vol. 13; p. 1156812
• Main Authors: Belykh, Evgenii, Bardonova, Liudmila, Abramov, Irakliy, Byvaltsev, Vadim A, Kerymbayev, Talgat, Yu, Kwanha, Healey, Debbie R, Luna-Melendez, Ernesto, Deneen, Benjamin, Mehta, Shwetal, Liu, James K, Preul, Mark C
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.05.2023
• Subjects: 5-aminolevulinic acid; fluorescein sodium; fluorescence guided surgery; glioma; indocyanine green; laser scanning microscopy; Oncology; protoporphyrin IX; fluorescein sodium; fluorescence guided surgery; indocyanine green; glioma; 5-aminolevulinic acid; laser scanning microscopy

Surgical resection remains the first-line treatment for gliomas. Several fluorescent dyes are currently in use to augment intraoperative tumor visualization, but information on their comparative effectiveness is lacking. We performed systematic assessment of fluorescein sodium (FNa), 5-aminolevulini...