Resveratrol induces acute endothelium-dependent renal vasodilation mediated through nitric oxide and reactive oxygen species scavenging

• Published in: American journal of physiology. Renal physiology Vol. 306; no. 5; pp. F542 - F550
• Main Authors: Gordish, Kevin L, Beierwaltes, William H
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2014
• Subjects: Acute Disease; Animals; Bioavailability; Chemical synthesis; Disease Models, Animal; Endothelium; Inhibitor drugs; Kidney - blood supply; Kidney - metabolism; Male; Nitric oxide; Nitric Oxide - metabolism; Phenols; Physiology; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Renal Circulation - drug effects; Renal Circulation - physiology; Stilbenes - pharmacology; Vascular Resistance - drug effects; Vasodilation - drug effects; Vasodilation - physiology; prostaglandins; nitric oxide; tempol; resveratrol; renal hemodynamics; reactive oxygen species

Resveratrol is suggested to have beneficial cardiovascular and renoprotective effects. Resveratrol increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) synthesis. We hypothesized resveratrol acts as an acute renal vasodilator, mediated through increased NO production a...