Ypd1 Is an Essential Protein of the Major Fungal Pathogen Aspergillus fumigatus and a Key Element in the Phosphorelay That Is Targeted by the Antifungal Drug Fludioxonil

• Published in: Frontiers in fungal biology Vol. 2; p. 756990
• Main Authors: Schruefer, Sebastian, Spadinger, Anja, Kleinemeier, Christoph, Schmid, Laura, Ebel, Frank
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.10.2021
• Subjects: fludioxonil; Fungal Biology; HOG pathway; HPt protein; Skn7; TcsC; Ypd1; TcsC; fludioxonil; HOG pathway; HPt protein; Skn7; Ypd1

is a major fungal pathogen causing life threatening infections in immunocompromised humans and certain animals. The HOG pathway is for two reasons interesting in this context: firstly, it is a stress signaling pathway that contributes to the ability of this pathogen to adapt to various stress condit...