Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

• Published in: Advanced drug delivery reviews Vol. 174; pp. 265 - 293
• Main Authors: Heinrich, Marcel A., Mostafa, Ahmed M.R.H., Morton, Jennifer P., Hawinkels, Lukas J.A.C., Prakash, Jai
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2021
• Subjects: Animals; Bioprinting; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - pathology; Disease Models, Animal; Disease Progression; Drug Development - methods; Genetically engineered mouse models; Humans; Mice; Mice, Transgenic; Models, Biological; Pancreatic ductal adenocarcinoma; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; Tumor Microenvironment; Tumor-on-chip; Bioprinting; Genetically engineered mouse models; Tumor-on-chip; Tumor microenvironment; Pancreatic ductal adenocarcinoma

[Display omitted] Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7–8%, emphasizing the need for novel effective therapeutics against PDAC. However only a fraction of therapeutics which seemed promising in the laboratory en...