Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry

•An overview of recent advances in MSI for drug localization is presented.•MSI provides label-free imaging of drugs and metabolites at high lateral resolution.•Spatial-profiling of drugs enables rapid drug localization with limited spatial detail.•Direct quantification of drugs in tissues by MSI is...

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Published inCurrent opinion in chemical biology Vol. 44; pp. 93 - 100
Main Authors Prideaux, Brendan, Lenaerts, Anne, Dartois, Véronique
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2018
Subjects
Animals
Chromatography, Liquid - instrumentation
Chromatography, Liquid - methods
Drug Discovery - instrumentation
Drug Discovery - methods
Equipment Design
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - metabolism
Tissue Distribution
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Abstract •An overview of recent advances in MSI for drug localization is presented.•MSI provides label-free imaging of drugs and metabolites at high lateral resolution.•Spatial-profiling of drugs enables rapid drug localization with limited spatial detail.•Direct quantification of drugs in tissues by MSI is challenging.•LCM-LC/MS/MS enables absolute quantification of drugs within defined tissue regions. Mass spectrometry imaging (MSI) is a powerful label-free technique for visualizing drug and metabolite distributions in biological tissues. In this review, we discuss recent developments in MSI and spatial profiling technologies to visualize and quantify drug distributions in tissues. We also present recent examples of applications of these technologies for assessing drug distribution within tissues and individual cells. Finally, we focus on an emerging technique coupling laser capture microdissection (LCM) to quantitative mass spectrometry, which combines the respective advantages of imaging and conventional liquid chromatography mass spectrometry, and thus enables spatially resolved drug quantification.
AbstractList Mass spectrometry imaging (MSI) is a powerful label-free technique for visualizing drug and metabolite distributions in biological tissues. In this review, we discuss recent developments in MSI and spatial profiling technologies to visualize and quantify drug distributions in tissues. We also present recent examples of applications of these technologies for assessing drug distribution within tissues and individual cells. Finally, we focus on an emerging technique coupling laser capture microdissection (LCM) to quantitative mass spectrometry, which combines the respective advantages of imaging and conventional liquid chromatography mass spectrometry, and thus enables spatially resolved drug quantification.
•An overview of recent advances in MSI for drug localization is presented.•MSI provides label-free imaging of drugs and metabolites at high lateral resolution.•Spatial-profiling of drugs enables rapid drug localization with limited spatial detail.•Direct quantification of drugs in tissues by MSI is challenging.•LCM-LC/MS/MS enables absolute quantification of drugs within defined tissue regions. Mass spectrometry imaging (MSI) is a powerful label-free technique for visualizing drug and metabolite distributions in biological tissues. In this review, we discuss recent developments in MSI and spatial profiling technologies to visualize and quantify drug distributions in tissues. We also present recent examples of applications of these technologies for assessing drug distribution within tissues and individual cells. Finally, we focus on an emerging technique coupling laser capture microdissection (LCM) to quantitative mass spectrometry, which combines the respective advantages of imaging and conventional liquid chromatography mass spectrometry, and thus enables spatially resolved drug quantification.
Author Lenaerts, Anne
Prideaux, Brendan
Dartois, Véronique
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Snippet •An overview of recent advances in MSI for drug localization is presented.•MSI provides label-free imaging of drugs and metabolites at high lateral...
Mass spectrometry imaging (MSI) is a powerful label-free technique for visualizing drug and metabolite distributions in biological tissues. In this review, we...
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SubjectTerms Animals
Chromatography, Liquid - instrumentation
Chromatography, Liquid - methods
Drug Discovery - instrumentation
Drug Discovery - methods
Equipment Design
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - metabolism
Tissue Distribution
Title Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry
URI https://dx.doi.org/10.1016/j.cbpa.2018.05.007
https://www.ncbi.nlm.nih.gov/pubmed/29957376
https://search.proquest.com/docview/2062828196
Volume 44
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