2-(2-[2-Dimethylaminothiazol-5-yl]Ethenyl)-6- (2-[Fluoro]Ethoxy)Benzoxazole: A Novel PET Agent for In Vivo Detection of Dense Amyloid Plaques in Alzheimer's Disease Patients

• Published in: The Journal of nuclear medicine (1978) Vol. 48; no. 4; pp. 553 - 561
• Main Authors: Kudo, Yukitsuka, Okamura, Nobuyuki, Furumoto, Shozo, Tashiro, Manabu, Furukawa, Katsutoshi, Maruyama, Masahiro, Itoh, Masatoshi, Iwata, Ren, Yanai, Kazuhiko, Arai, Hiroyuki
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01.04.2007; Society of Nuclear Medicine
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid - chemistry; Animals; Benzoxazoles - pharmacokinetics; Brain; Clinical trials; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Permeability; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - methods; R&D; Radiopharmaceuticals - pharmacokinetics; Research & development; Studies; Technological change; Thiazoles - pharmacokinetics; Tissues

Extensive deposition of dense amyloid fibrils is a characteristic neuropathologic hallmark in Alzheimer's disease (AD). Noninvasive detection of these molecules is potentially useful for early and precise detection of patients with AD. This study reports a novel compound, 2-(2-[2-dimethylaminot...