The I148M PNPLA3 variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value

• Published in: Frontiers in nutrition (Lausanne) Vol. 10; p. 1101341
• Main Authors: Paolini, Erika, Longo, Miriam, Meroni, Marica, Tria, Giada, Cespiati, Annalisa, Lombardi, Rosa, Badiali, Sara, Maggioni, Marco, Fracanzani, Anna Ludovica, Dongiovanni, Paola
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.03.2023
• Subjects: dietary supplementation; NAD; niacin; nutrigenomic; Nutrition; PNPLA3 I148M; NAD; nutrigenomic; niacin; PNPLA3 I148M; dietary supplementation

The PNPLA3 p.I148M impact on fat accumulation can be modulated by nutrients. Niacin (Vitamin B3) reduced triglycerides synthesis in and NAFLD models. In this study, we aimed to investigate the niacin-I148M polymorphism crosstalk in NAFLD patients and examine niacin's beneficial effect in reduci...