A single-cell transcriptomic landscape of mouse testicular aging
[Display omitted] •The first single-cell transcriptomic atlases of testes of young and old mice were constructed.•Revealed aging-associated heterogenous differentially expressed genes in mouse testes.•Discovered aging-associated dysregulation of multiple biological processes in mouse testes.•Aging d...
Saved in:
| Published in | Journal of advanced research Vol. 53; pp. 219 - 234 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Egypt
Elsevier B.V
01.11.2023
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
•The first single-cell transcriptomic atlases of testes of young and old mice were constructed.•Revealed aging-associated heterogenous differentially expressed genes in mouse testes.•Discovered aging-associated dysregulation of multiple biological processes in mouse testes.•Aging disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia.•Aging increased a subtype of aging-specific macrophages.
Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in testicular tissue is still missing.
We aimed to dissect aging-associated molecular characteristics in testes of mice.
Single-cell transcriptomic sequencing and analysis were conducted in testes of young (2 months old) and old mice (24 months old). Immunofluorescences and immunochemistry were used to characterize aging-associated phenotypes and verify single cell sequence results.
Here, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. In-depth dissection of aging-dependent transcriptional alterations in specific cell types revealed multiple dysregulated biological processes such as increased ‘senescence-associated secretory phenotype’ and ‘inflammation’, which were major aging-associated characteristics. Further analysis of aging-related differentially expressed genes uncovered a disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Importantly, for the first time, our results identified an increased subtype of aging-specific macrophages, which may contribute to a hostile proinflammatory microenvironment during testicular aging.
Taken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testes and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging, which may shed light on developing novel potential diagnostic biomarkers and therapeutic targets for age-associated male subfertility. |
|---|---|
| AbstractList | Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in testicular tissue is still missing.
We aimed to dissect aging-associated molecular characteristics in testes of mice.
Single-cell transcriptomic sequencing and analysis were conducted in testes of young (2 months old) and old mice (24 months old). Immunofluorescences and immunochemistry were used to characterize aging-associated phenotypes and verify single cell sequence results.
Here, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. In-depth dissection of aging-dependent transcriptional alterations in specific cell types revealed multiple dysregulated biological processes such as increased 'senescence-associated secretory phenotype' and 'inflammation', which were major aging-associated characteristics. Further analysis of aging-related differentially expressed genes uncovered a disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Importantly, for the first time, our results identified an increased subtype of aging-specific macrophages, which may contribute to a hostile proinflammatory microenvironment during testicular aging.
Taken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testes and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging, which may shed light on developing novel potential diagnostic biomarkers and therapeutic targets for age-associated male subfertility. [Display omitted] •The first single-cell transcriptomic atlases of testes of young and old mice were constructed.•Revealed aging-associated heterogenous differentially expressed genes in mouse testes.•Discovered aging-associated dysregulation of multiple biological processes in mouse testes.•Aging disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia.•Aging increased a subtype of aging-specific macrophages. Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in testicular tissue is still missing. We aimed to dissect aging-associated molecular characteristics in testes of mice. Single-cell transcriptomic sequencing and analysis were conducted in testes of young (2 months old) and old mice (24 months old). Immunofluorescences and immunochemistry were used to characterize aging-associated phenotypes and verify single cell sequence results. Here, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. In-depth dissection of aging-dependent transcriptional alterations in specific cell types revealed multiple dysregulated biological processes such as increased ‘senescence-associated secretory phenotype’ and ‘inflammation’, which were major aging-associated characteristics. Further analysis of aging-related differentially expressed genes uncovered a disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Importantly, for the first time, our results identified an increased subtype of aging-specific macrophages, which may contribute to a hostile proinflammatory microenvironment during testicular aging. Taken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testes and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging, which may shed light on developing novel potential diagnostic biomarkers and therapeutic targets for age-associated male subfertility. Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in testicular tissue is still missing.INTRODUCTIONAdvanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in testicular tissue is still missing.We aimed to dissect aging-associated molecular characteristics in testes of mice.OBJECTIVESWe aimed to dissect aging-associated molecular characteristics in testes of mice.Single-cell transcriptomic sequencing and analysis were conducted in testes of young (2 months old) and old mice (24 months old). Immunofluorescences and immunochemistry were used to characterize aging-associated phenotypes and verify single cell sequence results.METHODSSingle-cell transcriptomic sequencing and analysis were conducted in testes of young (2 months old) and old mice (24 months old). Immunofluorescences and immunochemistry were used to characterize aging-associated phenotypes and verify single cell sequence results.Here, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. In-depth dissection of aging-dependent transcriptional alterations in specific cell types revealed multiple dysregulated biological processes such as increased 'senescence-associated secretory phenotype' and 'inflammation', which were major aging-associated characteristics. Further analysis of aging-related differentially expressed genes uncovered a disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Importantly, for the first time, our results identified an increased subtype of aging-specific macrophages, which may contribute to a hostile proinflammatory microenvironment during testicular aging.RESULTSHere, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. In-depth dissection of aging-dependent transcriptional alterations in specific cell types revealed multiple dysregulated biological processes such as increased 'senescence-associated secretory phenotype' and 'inflammation', which were major aging-associated characteristics. Further analysis of aging-related differentially expressed genes uncovered a disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Importantly, for the first time, our results identified an increased subtype of aging-specific macrophages, which may contribute to a hostile proinflammatory microenvironment during testicular aging.Taken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testes and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging, which may shed light on developing novel potential diagnostic biomarkers and therapeutic targets for age-associated male subfertility.CONCLUSIONTaken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testes and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging, which may shed light on developing novel potential diagnostic biomarkers and therapeutic targets for age-associated male subfertility. Introduction: Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse reproductive outcomes such as reduced fertility rates, increased pregnancy loss, and poor childhood health. Yet, a systematic profiling of aging-associated molecular and cellular alterations in testicular tissue is still missing. Objectives: We aimed to dissect aging-associated molecular characteristics in testes of mice. Methods: Single-cell transcriptomic sequencing and analysis were conducted in testes of young (2 months old) and old mice (24 months old). Immunofluorescences and immunochemistry were used to characterize aging-associated phenotypes and verify single cell sequence results. Results: Here, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. In-depth dissection of aging-dependent transcriptional alterations in specific cell types revealed multiple dysregulated biological processes such as increased ‘senescence-associated secretory phenotype’ and ‘inflammation’, which were major aging-associated characteristics. Further analysis of aging-related differentially expressed genes uncovered a disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Importantly, for the first time, our results identified an increased subtype of aging-specific macrophages, which may contribute to a hostile proinflammatory microenvironment during testicular aging. Conclusion: Taken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testes and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging, which may shed light on developing novel potential diagnostic biomarkers and therapeutic targets for age-associated male subfertility. |
| Author | Tang, Li Zhao, Shanchao Xu, Chengchao Li, Zhijie Zhang, Wei Xia, Siyu Xiao, Wei Song, Yali Yang, Chuanbin Yang, Jing Wang, Shuang Liu, Jianqiao Cao, Min Wang, Jigang |
| Author_xml | – sequence: 1 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 2 givenname: Siyu surname: Xia fullname: Xia, Siyu organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 3 givenname: Wei surname: Xiao fullname: Xiao, Wei organization: Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou 510006, China – sequence: 4 givenname: Yali surname: Song fullname: Song, Yali organization: Center for Reproductive Medicine, Dongguan Maternal and Child Health Care Hospital, Southern Medical University, Dongguan 523000, China – sequence: 5 givenname: Li surname: Tang fullname: Tang, Li organization: Center for Reproductive Medicine, Dongguan Maternal and Child Health Care Hospital, Southern Medical University, Dongguan 523000, China – sequence: 6 givenname: Min surname: Cao fullname: Cao, Min organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 7 givenname: Jing surname: Yang fullname: Yang, Jing organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 8 givenname: Shuang surname: Wang fullname: Wang, Shuang organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 9 givenname: Zhijie surname: Li fullname: Li, Zhijie organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 10 givenname: Chengchao surname: Xu fullname: Xu, Chengchao organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 11 givenname: Jianqiao surname: Liu fullname: Liu, Jianqiao email: liujqssz@gzhmu.edu.cn organization: Key Laboratory for Reproductive Medicine of Guangdong Province, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China – sequence: 12 givenname: Shanchao surname: Zhao fullname: Zhao, Shanchao email: lulululu@smu.edu.cn organization: Department of Urology, the Third Affiliated Hospital of Southern Medical University, and Nanfang Hospital, Southern Medical University, Guangzhou, 510500, China – sequence: 13 givenname: Chuanbin surname: Yang fullname: Yang, Chuanbin email: h1094103@connect.hku.hk organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China – sequence: 14 givenname: Jigang surname: Wang fullname: Wang, Jigang email: jgwang@icmm.ac.cn organization: Department of Nephrology, and Shenzhen key Laboratory of Kidney Diseases, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36528294$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UctuFDEQtFAQeZAf4IDmyGWG9mMeljgQRRAiReICZ8tu96w8mhkv9iwSf4-XTXLgEF9sWVXVXVWX7GyNKzH2jkPDgXcfp2ayiRoBQjRcNAD9K3YhQEPNhVBnz28pztl1zhOUI4dBc_6GncuuFYPQ6oJ9vqlyWHcz1UjzXG3JrhlT2G9xCVjNdvUZ7Z6qOFZLPGSqNspbwMNsU2V3hfmWvR7tnOn68b5iP79--XH7rX74fnd_e_NQo-q6rR6sHZWTDnvqvHaD94pQjhI9QEfOKtchaQ_CE1EPirgAcLp3bS-BlJJX7P6k66OdzD6FxaY_Jtpg_n3EtDM2lc1mMl0ZokHLsZVCqZYGpVtHesReIOcSi9aHk9Y-xV-HYsgsIR_925WKSSP6tm0HDhIK9P0j9OAW8s-DnxIsgOEEwBRzTjQaDJvdQlxLlmE2HMyxLzOZY1_m2JfhwpS-ClX8R31Sf5H06USiEvbvQMlkDLQi-ZAIt5JGeIn-F10sraY |
| CitedBy_id | crossref_primary_10_1002_advs_202410808 crossref_primary_10_1111_acel_70032 crossref_primary_10_3389_fendo_2024_1291389 crossref_primary_10_1002_mef2_70003 crossref_primary_10_1016_j_envpol_2024_123742 crossref_primary_10_1016_j_envpol_2024_125503 crossref_primary_10_3389_fendo_2024_1423801 crossref_primary_10_1242_dev_202296 crossref_primary_10_1186_s12915_025_02186_y crossref_primary_10_1186_s40364_024_00666_x crossref_primary_10_1016_j_jare_2024_12_018 crossref_primary_10_1080_19396368_2024_2388121 crossref_primary_10_1111_acel_70019 crossref_primary_10_3389_fendo_2024_1394812 crossref_primary_10_1038_s41598_024_65710_0 crossref_primary_10_1111_cpr_13797 crossref_primary_10_1038_s43587_025_00824_2 crossref_primary_10_1016_j_jpha_2023_04_006 crossref_primary_10_1016_S1875_5364_24_60639_4 crossref_primary_10_1186_s40104_025_01177_x crossref_primary_10_3390_foods13152344 crossref_primary_10_1016_j_jep_2024_118673 crossref_primary_10_1002_adbi_202400120 crossref_primary_10_1186_s12958_024_01316_5 crossref_primary_10_1007_s11427_024_2638_9 crossref_primary_10_1038_s41598_025_86867_2 crossref_primary_10_1002_advs_202305449 crossref_primary_10_1016_j_jes_2023_08_032 crossref_primary_10_1038_s43587_024_00770_5 |
| Cites_doi | 10.1038/ncomms8866 10.1038/s41586-019-1365-2 10.1038/s41423-020-00541-3 10.1016/j.arr.2020.101156 10.1016/j.cell.2016.05.017 10.1016/j.exger.2021.111460 10.1038/nature08980 10.1016/j.tem.2010.03.001 10.1681/ASN.2018090912 10.1016/j.mad.2021.111519 10.1186/s13059-018-1440-2 10.1038/s41422-020-00412-6 10.1634/stemcells.2005-0580 10.2741/S365 10.3390/cells10113114 10.1007/978-94-007-2561-4_5 10.1016/j.jconrel.2015.05.282 10.1002/hep.31485 10.1186/s12958-015-0028-x 10.1098/rsif.2019.0311 10.1038/nmeth.4463 10.18632/aging.100875 10.1007/s10815-016-0663-y 10.1101/gr.253880.119 10.1038/s41596-020-0292-x 10.1016/j.exger.2016.08.012 10.1093/humupd/dmh030 10.1016/j.devcel.2020.05.010 10.1038/nbt.4096 10.1016/j.bbadis.2012.02.008 10.1016/S1472-6483(10)60676-1 10.1016/j.cell.2020.01.009 10.1095/biolreprod.110.088229 10.1093/biolre/ioab202 10.1038/s41593-019-0491-3 10.7554/eLife.68224 10.1016/j.stem.2018.08.007 10.1016/j.cell.2015.05.002 10.1007/s11357-020-00177-1 10.1007/s11357-020-00185-1 10.1016/j.celrep.2019.01.045 10.1111/febs.15570 10.1038/s41422-018-0099-2 10.1111/and.12816 10.1007/s11357-022-00573-9 10.1038/35041687 10.1073/pnas.2000362117 10.1016/j.cels.2015.12.004 10.4049/jimmunol.1002639 10.1007/s11357-020-00214-z 10.1016/j.devcel.2018.07.025 10.1371/journal.pgen.1009369 10.1111/and.13034 10.1016/j.jconrel.2010.09.015 10.1038/leu.2010.6 10.1038/s41580-019-0204-5 10.1016/j.cels.2019.03.003 10.1002/jmor.10287 10.1002/ctm2.789 10.1038/s41467-021-21246-9 10.1038/s42255-020-0196-7 |
| ContentType | Journal Article |
| Copyright | 2022 Copyright © 2022. Production and hosting by Elsevier B.V. Copyright © 2023. Production and hosting by Elsevier B.V. |
| Copyright_xml | – notice: 2022 – notice: Copyright © 2022. Production and hosting by Elsevier B.V. – notice: Copyright © 2023. Production and hosting by Elsevier B.V. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 DOA |
| DOI | 10.1016/j.jare.2022.12.007 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 2090-1224 |
| EndPage | 234 |
| ExternalDocumentID | oai_doaj_org_article_6c7e9093f532445e8495be9fc72c113c 36528294 10_1016_j_jare_2022_12_007 S2090123222002867 |
| Genre | Journal Article |
| GroupedDBID | --K 0R~ 0SF 1B1 1~5 4.4 457 4G. 53G 5VS 6I. 7-5 AACTN AAEDT AAEDW AAFTH AAIKJ AALRI AAXUO ABFRF ABMAC ACGFS ADBBV ADEZE AEFWE AEXQZ AFTJW AGHFR AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BCNDV E3Z EBS EJD FDB GROUPED_DOAJ GX1 HH5 HYE HZ~ IPNFZ IXB J1W KQ8 M41 NCXOZ O-L O9- OK1 OZT RIG ROL RPM SES SSZ UNMZH XH2 AAYWO AAYXX ACVFH ADCNI ADVLN AEUPX AFJKZ AFPUW AIGII AKBMS AKRWK AKYEP APXCP CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c466t-8aaf4b3bc7e6d9b8dd4ec3f3cd006eba4b6ce9d02deee704e1200b97b5730e443 |
| IEDL.DBID | DOA |
| ISSN | 2090-1232 2090-1224 |
| IngestDate | Wed Aug 27 01:27:16 EDT 2025 Fri Jul 11 03:37:00 EDT 2025 Thu Jan 02 22:53:52 EST 2025 Tue Jul 01 03:01:32 EDT 2025 Thu Apr 24 23:05:31 EDT 2025 Fri Feb 23 02:39:56 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Testis ScRNA-seq Senescence DEGs PCNA Single-cell RNA sequencing ROS Aging Inflammation FC |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2022. Production and hosting by Elsevier B.V. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c466t-8aaf4b3bc7e6d9b8dd4ec3f3cd006eba4b6ce9d02deee704e1200b97b5730e443 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/6c7e9093f532445e8495be9fc72c113c |
| PMID | 36528294 |
| PQID | 2755581030 |
| PQPubID | 23479 |
| PageCount | 16 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_6c7e9093f532445e8495be9fc72c113c proquest_miscellaneous_2755581030 pubmed_primary_36528294 crossref_citationtrail_10_1016_j_jare_2022_12_007 crossref_primary_10_1016_j_jare_2022_12_007 elsevier_sciencedirect_doi_10_1016_j_jare_2022_12_007 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-11-01 |
| PublicationDateYYYYMMDD | 2023-11-01 |
| PublicationDate_xml | – month: 11 year: 2023 text: 2023-11-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Egypt |
| PublicationPlace_xml | – name: Egypt |
| PublicationTitle | Journal of advanced research |
| PublicationTitleAlternate | J Adv Res |
| PublicationYear | 2023 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Giannessi (b0300) 2005; 263 Sun (b0325) 2020; 42 Matzkin (b0210) 2016; 8 D. Galvis et al. Galvis, D., et al. Schmidt (b0270) 2011; 84 Finkel, Holbrook (b0265) 2000; 408 Tan (b0045) 2020; 117 Kiss (b0195) 2020; 42 Huang (b0205) 2018; 50 He (b0060) 2020; 2 McGinnis, Murrow, Gartner (b0145) 2019; 8 Selvaratnam, Robaire (b0185) 2016; 84 Matzkin (b0200) 2021; 10 Wang (b0110) 2020; 180 Ma (b0105) 2021; 31 Efremova (b0165) 2020; 15 Hense (b0320) 2022; 44 Kimmel (b0305) 2019; 29 Ryu (b0275) 2006; 24 Kühnert, Nieschlag (b0290) 2004; 10 Mosser, Hamidzadeh, Goncalves (b0220) 2021; 18 Aibar (b0160) 2017; 14 Frungieri (b0025) 2021; 197 Zhang (b0310) 2021; 10 Wu (b0055) 2019; 30 Shami (b0075) 2020; 54 Longo, Fabrizio (b0015) 2012; 57 Ramilowski (b0250) 2015; 6 Gunes (b0285) 2016; 33 Kubben (b0260) 2016; 165 Zacchini (b0035) 2022; 106 Butler (b0140) 2018; 36 Amaral, Amaral, Ramalho-Santos (b0190) 2013; 5 Kenyon (b0005) 2010; 464 Aitken, De Iuliis (b0235) 2007; 14 Frungieri (b0215) 2018; 50 Lu (b0130) 2015; 210 Reproductive biology and endocrinology : RB&E, 2015. Jung (b0150) 2019 Campisi (b0010) 2019; 571 Cho (b0255) 2011; 186 Liao (b0280) 2021; 17 Mogilenko, Shchukina, Artyomov (b0295) 2021 Harris (b0020) 2011; 13 Wang (b0085) 2018; 23 González-Gualda (b0175) 2021; 288 Zhao (b0180) 2021; 152 Jan (b0040) 2012; 1822 Plant (b0240) 2010; 21 Macosko (b0135) 2015; 161 Jin (b0245) 2021; 12 Guo (b0065) 2018; 28 Journal of the Royal Society, Interface, 2019. Boukouvalas, Hensman, Rattray (b0225) 2018; 19 Uyar (b0115) 2020; 64 Sharma, R., et al. Ximerakis (b0095) 2019; 22 Mah, El-Osta, Karagiannis (b0230) 2010; 24 Sohni (b0070) 2019; 26 Green (b0080) 2018; 46 Liberzon (b0155) 2015; 1 (159): p. 20190311-20190311. Li (b0125) 2010; 148 Chu (b0100) 2021; 73 p. 35-35. Xia (b0090) 2022; 12 Zhang (b0120) 2021 Zhang (b0050) 2020; 21 Yousefzadeh (b0315) 2020; 42 Cho (10.1016/j.jare.2022.12.007_b0255) 2011; 186 He (10.1016/j.jare.2022.12.007_b0060) 2020; 2 10.1016/j.jare.2022.12.007_b0170 Jung (10.1016/j.jare.2022.12.007_b0150) 2019 Zhang (10.1016/j.jare.2022.12.007_b0120) 2021 Mah (10.1016/j.jare.2022.12.007_b0230) 2010; 24 Xia (10.1016/j.jare.2022.12.007_b0090) 2022; 12 Ximerakis (10.1016/j.jare.2022.12.007_b0095) 2019; 22 Selvaratnam (10.1016/j.jare.2022.12.007_b0185) 2016; 84 Wang (10.1016/j.jare.2022.12.007_b0085) 2018; 23 Frungieri (10.1016/j.jare.2022.12.007_b0025) 2021; 197 Frungieri (10.1016/j.jare.2022.12.007_b0215) 2018; 50 Shami (10.1016/j.jare.2022.12.007_b0075) 2020; 54 Matzkin (10.1016/j.jare.2022.12.007_b0200) 2021; 10 Finkel (10.1016/j.jare.2022.12.007_b0265) 2000; 408 Li (10.1016/j.jare.2022.12.007_b0125) 2010; 148 Liao (10.1016/j.jare.2022.12.007_b0280) 2021; 17 Harris (10.1016/j.jare.2022.12.007_b0020) 2011; 13 Aibar (10.1016/j.jare.2022.12.007_b0160) 2017; 14 Wu (10.1016/j.jare.2022.12.007_b0055) 2019; 30 Jin (10.1016/j.jare.2022.12.007_b0245) 2021; 12 Efremova (10.1016/j.jare.2022.12.007_b0165) 2020; 15 Liberzon (10.1016/j.jare.2022.12.007_b0155) 2015; 1 Matzkin (10.1016/j.jare.2022.12.007_b0210) 2016; 8 Zhang (10.1016/j.jare.2022.12.007_b0310) 2021; 10 Butler (10.1016/j.jare.2022.12.007_b0140) 2018; 36 Boukouvalas (10.1016/j.jare.2022.12.007_b0225) 2018; 19 Mogilenko (10.1016/j.jare.2022.12.007_b0295) 2021 Gunes (10.1016/j.jare.2022.12.007_b0285) 2016; 33 Aitken (10.1016/j.jare.2022.12.007_b0235) 2007; 14 Longo (10.1016/j.jare.2022.12.007_b0015) 2012; 57 Lu (10.1016/j.jare.2022.12.007_b0130) 2015; 210 Mosser (10.1016/j.jare.2022.12.007_b0220) 2021; 18 Campisi (10.1016/j.jare.2022.12.007_b0010) 2019; 571 Ramilowski (10.1016/j.jare.2022.12.007_b0250) 2015; 6 Sohni (10.1016/j.jare.2022.12.007_b0070) 2019; 26 Zhao (10.1016/j.jare.2022.12.007_b0180) 2021; 152 10.1016/j.jare.2022.12.007_b0030 Kiss (10.1016/j.jare.2022.12.007_b0195) 2020; 42 Huang (10.1016/j.jare.2022.12.007_b0205) 2018; 50 Ryu (10.1016/j.jare.2022.12.007_b0275) 2006; 24 Chu (10.1016/j.jare.2022.12.007_b0100) 2021; 73 Kühnert (10.1016/j.jare.2022.12.007_b0290) 2004; 10 Hense (10.1016/j.jare.2022.12.007_b0320) 2022; 44 Macosko (10.1016/j.jare.2022.12.007_b0135) 2015; 161 Plant (10.1016/j.jare.2022.12.007_b0240) 2010; 21 Wang (10.1016/j.jare.2022.12.007_b0110) 2020; 180 Ma (10.1016/j.jare.2022.12.007_b0105) 2021; 31 Tan (10.1016/j.jare.2022.12.007_b0045) 2020; 117 Kimmel (10.1016/j.jare.2022.12.007_b0305) 2019; 29 Amaral (10.1016/j.jare.2022.12.007_b0190) 2013; 5 Uyar (10.1016/j.jare.2022.12.007_b0115) 2020; 64 Jan (10.1016/j.jare.2022.12.007_b0040) 2012; 1822 Guo (10.1016/j.jare.2022.12.007_b0065) 2018; 28 Schmidt (10.1016/j.jare.2022.12.007_b0270) 2011; 84 Yousefzadeh (10.1016/j.jare.2022.12.007_b0315) 2020; 42 Giannessi (10.1016/j.jare.2022.12.007_b0300) 2005; 263 Sun (10.1016/j.jare.2022.12.007_b0325) 2020; 42 González-Gualda (10.1016/j.jare.2022.12.007_b0175) 2021; 288 Kubben (10.1016/j.jare.2022.12.007_b0260) 2016; 165 Kenyon (10.1016/j.jare.2022.12.007_b0005) 2010; 464 McGinnis (10.1016/j.jare.2022.12.007_b0145) 2019; 8 Zhang (10.1016/j.jare.2022.12.007_b0050) 2020; 21 Zacchini (10.1016/j.jare.2022.12.007_b0035) 2022; 106 Green (10.1016/j.jare.2022.12.007_b0080) 2018; 46 |
| References_xml | – volume: 117 start-page: 17832 year: 2020 end-page: 17841 ident: b0045 article-title: Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro publication-title: Proc Natl Acad Sci U S A – volume: 44 start-page: 1747 year: 2022 end-page: 1759 ident: b0320 article-title: Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary publication-title: Geroscience – volume: 42 start-page: 1119 year: 2020 end-page: 1132 ident: b0325 article-title: Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways publication-title: Geroscience – volume: 197 year: 2021 ident: b0025 article-title: Male and female gonadal ageing: its impact on health span and life span publication-title: Mech Ageing Dev – volume: 36 start-page: 411 year: 2018 end-page: 420 ident: b0140 article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species publication-title: Nat Biotechnol – volume: 42 start-page: 951 year: 2020 end-page: 961 ident: b0315 article-title: Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues publication-title: Geroscience – volume: 2 start-page: 293 year: 2020 end-page: 302 ident: b0060 article-title: Single-cell omics in ageing: a young and growing field publication-title: Nat Metab – volume: 17 start-page: e1009369 year: 2021 ident: b0280 article-title: Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation publication-title: PLoS Genet – reference: Reproductive biology and endocrinology : RB&E, 2015. – volume: 18 start-page: 579 year: 2021 end-page: 587 ident: b0220 article-title: Macrophages and the maintenance of homeostasis publication-title: Cell Mol Immunol – volume: 263 start-page: 39 year: 2005 end-page: 46 ident: b0300 article-title: Ultrastructure of testicular macrophages in aging mice publication-title: J Morphol – volume: 148 start-page: 292 year: 2010 end-page: 302 ident: b0125 article-title: A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery publication-title: J Control Release – reference: D. Galvis et al. Galvis, D., et al., – volume: 84 start-page: 698 year: 2011 end-page: 706 ident: b0270 article-title: In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function publication-title: Biol Reprod – start-page: 1 year: 2021 end-page: 15 ident: b0295 article-title: Immune ageing at single-cell resolution publication-title: Nat Rev Immunol – volume: 288 start-page: 56 year: 2021 end-page: 80 ident: b0175 article-title: A guide to assessing cellular senescence in vitro and in vivo publication-title: Febs j – volume: 408 start-page: 239 year: 2000 end-page: 247 ident: b0265 article-title: Oxidants, oxidative stress and the biology of ageing publication-title: Nature – volume: 28 start-page: 1141 year: 2018 end-page: 1157 ident: b0065 article-title: The adult human testis transcriptional cell atlas publication-title: Cell Res – volume: 50 year: 2018 ident: b0205 article-title: Steroidogenesis decline accompanied with reduced antioxidation and endoplasmic reticulum stress in mice testes during ageing publication-title: Andrologia – volume: 31 start-page: 415 year: 2021 end-page: 432 ident: b0105 article-title: Single-cell transcriptomic atlas of primate cardiopulmonary aging publication-title: Cell Res – volume: 165 start-page: 1361 year: 2016 end-page: 1374 ident: b0260 article-title: Repression of the Antioxidant NRF2 Pathway in Premature Aging publication-title: Cell – reference: : p. 35-35. – volume: 64 year: 2020 ident: b0115 article-title: Single-cell analyses of aging, inflammation and senescence publication-title: Ageing Res Rev – volume: 13 start-page: e184 year: 2011 end-page: e190 ident: b0020 article-title: Fertility and the aging male publication-title: Reviews in urology – reference: (159): p. 20190311-20190311. – volume: 12 start-page: e789 year: 2022 ident: b0090 article-title: A single-cell atlas of bisphenol A (BPA)-induced testicular injury in mice publication-title: Clin Transl Med – volume: 54 start-page: 529 year: 2020 end-page: 547.e12 ident: b0075 article-title: Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis publication-title: Dev Cell – volume: 571 start-page: 183 year: 2019 end-page: 192 ident: b0010 article-title: From discoveries in ageing research to therapeutics for healthy ageing publication-title: Nature – volume: 24 start-page: 1505 year: 2006 end-page: 1511 ident: b0275 article-title: Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal publication-title: Stem Cells – volume: 21 start-page: 488 year: 2010 end-page: 495 ident: b0240 article-title: Undifferentiated primate spermatogonia and their endocrine control publication-title: Trends Endocrinol Metab – volume: 21 start-page: 137 year: 2020 end-page: 150 ident: b0050 article-title: The ageing epigenome and its rejuvenation publication-title: Nat Rev Mol Cell Biol – volume: 23 start-page: 599 year: 2018 end-page: 614.e4 ident: b0085 article-title: Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis publication-title: Cell Stem Cell – volume: 1 start-page: 417 year: 2015 end-page: 425 ident: b0155 article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection publication-title: Cell Syst – start-page: 8 year: 2019 ident: b0150 article-title: Unified single-cell analysis of testis gene regulation and pathology in five mouse strains publication-title: Elife – volume: 50 start-page: e13034 year: 2018 ident: b0215 article-title: Ageing and inflammation in the male reproductive tract publication-title: Andrologia – volume: 186 start-page: 489 year: 2011 end-page: 498 ident: b0255 article-title: Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2–M3 publication-title: J Immunol – volume: 42 start-page: 429 year: 2020 end-page: 444 ident: b0195 article-title: Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain publication-title: Geroscience – volume: 14 start-page: 727 year: 2007 end-page: 733 ident: b0235 article-title: Origins and consequences of DNA damage in male germ cells publication-title: Reprod Biomed Online – reference: Sharma, R., et al., – volume: 57 start-page: 101 year: 2012 end-page: 121 ident: b0015 article-title: Chronological aging in Saccharomyces cerevisiae publication-title: Subcell Biochem – start-page: 10 year: 2021 ident: b0120 article-title: Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures publication-title: Elife – volume: 210 start-page: 134 year: 2015 end-page: 146 ident: b0130 article-title: Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer publication-title: J Control Release – volume: 14 start-page: 1083 year: 2017 end-page: 1086 ident: b0160 article-title: SCENIC: single-cell regulatory network inference and clustering publication-title: Nat Methods – volume: 106 start-page: 58 year: 2022 end-page: 65 ident: b0035 article-title: Delayed parenthood and its influence on offspring health: what have we learned from the mouse model† publication-title: Biol Reprod – volume: 22 start-page: 1696 year: 2019 end-page: 1708 ident: b0095 article-title: Single-cell transcriptomic profiling of the aging mouse brain publication-title: Nat Neurosci – volume: 73 start-page: 437 year: 2021 end-page: 448 ident: b0100 article-title: The Power of Single-Cell Analysis for the Study of Liver Pathobiology publication-title: Hepatology – volume: 5 start-page: 181 year: 2013 end-page: 197 ident: b0190 article-title: Aging and male reproductive function: a mitochondrial perspective publication-title: Front Biosci (Schol Ed) – volume: 10 year: 2021 ident: b0200 article-title: Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad publication-title: Cells – reference: Journal of the Royal Society, Interface, 2019. – volume: 1822 start-page: 1838 year: 2012 end-page: 1850 ident: b0040 article-title: Molecular control of rodent spermatogenesis publication-title: Biochim Biophys Acta – volume: 84 start-page: 12 year: 2016 end-page: 20 ident: b0185 article-title: Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production publication-title: Exp Gerontol – volume: 30 start-page: 23 year: 2019 end-page: 32 ident: b0055 article-title: Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis publication-title: J Am Soc Nephrol – volume: 180 start-page: 585 year: 2020 end-page: 600.e19 ident: b0110 article-title: Single-Cell Transcriptomic Atlas of Primate Ovarian Aging publication-title: Cell – volume: 6 start-page: 7866 year: 2015 ident: b0250 article-title: A draft network of ligand-receptor-mediated multicellular signalling in human publication-title: Nat Commun – volume: 8 start-page: 95 year: 2016 end-page: 110 ident: b0210 article-title: Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes publication-title: Aging (Albany NY) – volume: 8 start-page: 329 year: 2019 end-page: 337.e4 ident: b0145 article-title: DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors publication-title: Cell Syst – volume: 12 start-page: 1088 year: 2021 ident: b0245 article-title: Inference and analysis of cell-cell communication using Cell Chat publication-title: Nat Commun – volume: 29 start-page: 2088 year: 2019 end-page: 2103 ident: b0305 article-title: Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging publication-title: Genome Res – volume: 26 start-page: 1501 year: 2019 end-page: 1517.e4 ident: b0070 article-title: The Neonatal and Adult Human Testis Defined at the Single-Cell Level publication-title: Cell Rep – volume: 15 start-page: 1484 year: 2020 end-page: 1506 ident: b0165 article-title: Cell PhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes publication-title: Nat Protoc – volume: 33 start-page: 441 year: 2016 end-page: 454 ident: b0285 article-title: Effects of aging on the male reproductive system publication-title: J Assist Reprod Genet – volume: 10 start-page: 327 year: 2004 end-page: 339 ident: b0290 article-title: Reproductive functions of the ageing male* publication-title: Hum Reprod Update – volume: 10 year: 2021 ident: b0310 article-title: The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain publication-title: Elife – volume: 464 start-page: 504 year: 2010 end-page: 512 ident: b0005 article-title: The genetics of ageing publication-title: Nature – volume: 46 start-page: 651 year: 2018 end-page: 667.e10 ident: b0080 article-title: A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq publication-title: Dev Cell – volume: 152 year: 2021 ident: b0180 article-title: The dynamic changes of Nrf2 mediated oxidative stress, DNA damage and base excision repair in testis of rats during aging publication-title: Exp Gerontol – volume: 19 start-page: 65 year: 2018 ident: b0225 article-title: BGP: identifying gene-specific branching dynamics from single-cell data with a branching Gaussian process publication-title: Genome Biol – volume: 24 start-page: 679 year: 2010 end-page: 686 ident: b0230 article-title: gammaH2AX: a sensitive molecular marker of DNA damage and repair publication-title: Leukemia – volume: 161 start-page: 1202 year: 2015 end-page: 1214 ident: b0135 article-title: Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets publication-title: Cell – volume: 6 start-page: 7866 year: 2015 ident: 10.1016/j.jare.2022.12.007_b0250 article-title: A draft network of ligand-receptor-mediated multicellular signalling in human publication-title: Nat Commun doi: 10.1038/ncomms8866 – volume: 571 start-page: 183 issue: 7764 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0010 article-title: From discoveries in ageing research to therapeutics for healthy ageing publication-title: Nature doi: 10.1038/s41586-019-1365-2 – volume: 18 start-page: 579 issue: 3 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0220 article-title: Macrophages and the maintenance of homeostasis publication-title: Cell Mol Immunol doi: 10.1038/s41423-020-00541-3 – volume: 64 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0115 article-title: Single-cell analyses of aging, inflammation and senescence publication-title: Ageing Res Rev doi: 10.1016/j.arr.2020.101156 – start-page: 10 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0120 article-title: Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures publication-title: Elife – volume: 165 start-page: 1361 issue: 6 year: 2016 ident: 10.1016/j.jare.2022.12.007_b0260 article-title: Repression of the Antioxidant NRF2 Pathway in Premature Aging publication-title: Cell doi: 10.1016/j.cell.2016.05.017 – volume: 152 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0180 article-title: The dynamic changes of Nrf2 mediated oxidative stress, DNA damage and base excision repair in testis of rats during aging publication-title: Exp Gerontol doi: 10.1016/j.exger.2021.111460 – volume: 464 start-page: 504 issue: 7288 year: 2010 ident: 10.1016/j.jare.2022.12.007_b0005 article-title: The genetics of ageing publication-title: Nature doi: 10.1038/nature08980 – volume: 21 start-page: 488 issue: 8 year: 2010 ident: 10.1016/j.jare.2022.12.007_b0240 article-title: Undifferentiated primate spermatogonia and their endocrine control publication-title: Trends Endocrinol Metab doi: 10.1016/j.tem.2010.03.001 – volume: 30 start-page: 23 issue: 1 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0055 article-title: Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2018090912 – volume: 197 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0025 article-title: Male and female gonadal ageing: its impact on health span and life span publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2021.111519 – volume: 19 start-page: 65 issue: 1 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0225 article-title: BGP: identifying gene-specific branching dynamics from single-cell data with a branching Gaussian process publication-title: Genome Biol doi: 10.1186/s13059-018-1440-2 – volume: 31 start-page: 415 issue: 4 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0105 article-title: Single-cell transcriptomic atlas of primate cardiopulmonary aging publication-title: Cell Res doi: 10.1038/s41422-020-00412-6 – volume: 24 start-page: 1505 issue: 6 year: 2006 ident: 10.1016/j.jare.2022.12.007_b0275 article-title: Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal publication-title: Stem Cells doi: 10.1634/stemcells.2005-0580 – volume: 5 start-page: 181 year: 2013 ident: 10.1016/j.jare.2022.12.007_b0190 article-title: Aging and male reproductive function: a mitochondrial perspective publication-title: Front Biosci (Schol Ed) doi: 10.2741/S365 – volume: 10 issue: 11 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0200 article-title: Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad publication-title: Cells doi: 10.3390/cells10113114 – volume: 57 start-page: 101 year: 2012 ident: 10.1016/j.jare.2022.12.007_b0015 article-title: Chronological aging in Saccharomyces cerevisiae publication-title: Subcell Biochem doi: 10.1007/978-94-007-2561-4_5 – volume: 210 start-page: 134 year: 2015 ident: 10.1016/j.jare.2022.12.007_b0130 article-title: Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer publication-title: J Control Release doi: 10.1016/j.jconrel.2015.05.282 – volume: 73 start-page: 437 issue: 1 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0100 article-title: The Power of Single-Cell Analysis for the Study of Liver Pathobiology publication-title: Hepatology doi: 10.1002/hep.31485 – start-page: 8 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0150 article-title: Unified single-cell analysis of testis gene regulation and pathology in five mouse strains publication-title: Elife – ident: 10.1016/j.jare.2022.12.007_b0030 doi: 10.1186/s12958-015-0028-x – ident: 10.1016/j.jare.2022.12.007_b0170 doi: 10.1098/rsif.2019.0311 – volume: 14 start-page: 1083 issue: 11 year: 2017 ident: 10.1016/j.jare.2022.12.007_b0160 article-title: SCENIC: single-cell regulatory network inference and clustering publication-title: Nat Methods doi: 10.1038/nmeth.4463 – volume: 8 start-page: 95 issue: 1 year: 2016 ident: 10.1016/j.jare.2022.12.007_b0210 article-title: Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes publication-title: Aging (Albany NY) doi: 10.18632/aging.100875 – volume: 33 start-page: 441 issue: 4 year: 2016 ident: 10.1016/j.jare.2022.12.007_b0285 article-title: Effects of aging on the male reproductive system publication-title: J Assist Reprod Genet doi: 10.1007/s10815-016-0663-y – volume: 29 start-page: 2088 issue: 12 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0305 article-title: Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging publication-title: Genome Res doi: 10.1101/gr.253880.119 – volume: 15 start-page: 1484 issue: 4 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0165 article-title: Cell PhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes publication-title: Nat Protoc doi: 10.1038/s41596-020-0292-x – volume: 84 start-page: 12 year: 2016 ident: 10.1016/j.jare.2022.12.007_b0185 article-title: Overexpression of catalase in mice reduces age-related oxidative stress and maintains sperm production publication-title: Exp Gerontol doi: 10.1016/j.exger.2016.08.012 – volume: 10 start-page: 327 issue: 4 year: 2004 ident: 10.1016/j.jare.2022.12.007_b0290 article-title: Reproductive functions of the ageing male* publication-title: Hum Reprod Update doi: 10.1093/humupd/dmh030 – volume: 54 start-page: 529 issue: 4 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0075 article-title: Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis publication-title: Dev Cell doi: 10.1016/j.devcel.2020.05.010 – volume: 36 start-page: 411 issue: 5 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0140 article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species publication-title: Nat Biotechnol doi: 10.1038/nbt.4096 – start-page: 1 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0295 article-title: Immune ageing at single-cell resolution publication-title: Nat Rev Immunol – volume: 1822 start-page: 1838 issue: 12 year: 2012 ident: 10.1016/j.jare.2022.12.007_b0040 article-title: Molecular control of rodent spermatogenesis publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2012.02.008 – volume: 14 start-page: 727 issue: 6 year: 2007 ident: 10.1016/j.jare.2022.12.007_b0235 article-title: Origins and consequences of DNA damage in male germ cells publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(10)60676-1 – volume: 180 start-page: 585 issue: 3 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0110 article-title: Single-Cell Transcriptomic Atlas of Primate Ovarian Aging publication-title: Cell doi: 10.1016/j.cell.2020.01.009 – volume: 13 start-page: e184 issue: 4 year: 2011 ident: 10.1016/j.jare.2022.12.007_b0020 article-title: Fertility and the aging male publication-title: Reviews in urology – volume: 84 start-page: 698 issue: 4 year: 2011 ident: 10.1016/j.jare.2022.12.007_b0270 article-title: In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function publication-title: Biol Reprod doi: 10.1095/biolreprod.110.088229 – volume: 106 start-page: 58 issue: 1 year: 2022 ident: 10.1016/j.jare.2022.12.007_b0035 article-title: Delayed parenthood and its influence on offspring health: what have we learned from the mouse model† publication-title: Biol Reprod doi: 10.1093/biolre/ioab202 – volume: 22 start-page: 1696 issue: 10 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0095 article-title: Single-cell transcriptomic profiling of the aging mouse brain publication-title: Nat Neurosci doi: 10.1038/s41593-019-0491-3 – volume: 10 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0310 article-title: The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain publication-title: Elife doi: 10.7554/eLife.68224 – volume: 23 start-page: 599 issue: 4 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0085 article-title: Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis publication-title: Cell Stem Cell doi: 10.1016/j.stem.2018.08.007 – volume: 161 start-page: 1202 issue: 5 year: 2015 ident: 10.1016/j.jare.2022.12.007_b0135 article-title: Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets publication-title: Cell doi: 10.1016/j.cell.2015.05.002 – volume: 42 start-page: 429 issue: 2 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0195 article-title: Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain publication-title: Geroscience doi: 10.1007/s11357-020-00177-1 – volume: 42 start-page: 951 issue: 3 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0315 article-title: Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues publication-title: Geroscience doi: 10.1007/s11357-020-00185-1 – volume: 26 start-page: 1501 issue: 6 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0070 article-title: The Neonatal and Adult Human Testis Defined at the Single-Cell Level publication-title: Cell Rep doi: 10.1016/j.celrep.2019.01.045 – volume: 288 start-page: 56 issue: 1 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0175 article-title: A guide to assessing cellular senescence in vitro and in vivo publication-title: Febs j doi: 10.1111/febs.15570 – volume: 28 start-page: 1141 issue: 12 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0065 article-title: The adult human testis transcriptional cell atlas publication-title: Cell Res doi: 10.1038/s41422-018-0099-2 – volume: 50 issue: 1 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0205 article-title: Steroidogenesis decline accompanied with reduced antioxidation and endoplasmic reticulum stress in mice testes during ageing publication-title: Andrologia doi: 10.1111/and.12816 – volume: 44 start-page: 1747 issue: 3 year: 2022 ident: 10.1016/j.jare.2022.12.007_b0320 article-title: Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary publication-title: Geroscience doi: 10.1007/s11357-022-00573-9 – volume: 408 start-page: 239 issue: 6809 year: 2000 ident: 10.1016/j.jare.2022.12.007_b0265 article-title: Oxidants, oxidative stress and the biology of ageing publication-title: Nature doi: 10.1038/35041687 – volume: 117 start-page: 17832 issue: 30 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0045 article-title: Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.2000362117 – volume: 1 start-page: 417 issue: 6 year: 2015 ident: 10.1016/j.jare.2022.12.007_b0155 article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection publication-title: Cell Syst doi: 10.1016/j.cels.2015.12.004 – volume: 186 start-page: 489 issue: 1 year: 2011 ident: 10.1016/j.jare.2022.12.007_b0255 article-title: Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2–M3 publication-title: J Immunol doi: 10.4049/jimmunol.1002639 – volume: 42 start-page: 1119 issue: 4 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0325 article-title: Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways publication-title: Geroscience doi: 10.1007/s11357-020-00214-z – volume: 46 start-page: 651 issue: 5 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0080 article-title: A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq publication-title: Dev Cell doi: 10.1016/j.devcel.2018.07.025 – volume: 17 start-page: e1009369 issue: 7 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0280 article-title: Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation publication-title: PLoS Genet doi: 10.1371/journal.pgen.1009369 – volume: 50 start-page: e13034 issue: 11 year: 2018 ident: 10.1016/j.jare.2022.12.007_b0215 article-title: Ageing and inflammation in the male reproductive tract publication-title: Andrologia doi: 10.1111/and.13034 – volume: 148 start-page: 292 issue: 3 year: 2010 ident: 10.1016/j.jare.2022.12.007_b0125 article-title: A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery publication-title: J Control Release doi: 10.1016/j.jconrel.2010.09.015 – volume: 24 start-page: 679 issue: 4 year: 2010 ident: 10.1016/j.jare.2022.12.007_b0230 article-title: gammaH2AX: a sensitive molecular marker of DNA damage and repair publication-title: Leukemia doi: 10.1038/leu.2010.6 – volume: 21 start-page: 137 issue: 3 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0050 article-title: The ageing epigenome and its rejuvenation publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-019-0204-5 – volume: 8 start-page: 329 issue: 4 year: 2019 ident: 10.1016/j.jare.2022.12.007_b0145 article-title: DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors publication-title: Cell Syst doi: 10.1016/j.cels.2019.03.003 – volume: 263 start-page: 39 issue: 1 year: 2005 ident: 10.1016/j.jare.2022.12.007_b0300 article-title: Ultrastructure of testicular macrophages in aging mice publication-title: J Morphol doi: 10.1002/jmor.10287 – volume: 12 start-page: e789 issue: 3 year: 2022 ident: 10.1016/j.jare.2022.12.007_b0090 article-title: A single-cell atlas of bisphenol A (BPA)-induced testicular injury in mice publication-title: Clin Transl Med doi: 10.1002/ctm2.789 – volume: 12 start-page: 1088 issue: 1 year: 2021 ident: 10.1016/j.jare.2022.12.007_b0245 article-title: Inference and analysis of cell-cell communication using Cell Chat publication-title: Nat Commun doi: 10.1038/s41467-021-21246-9 – volume: 2 start-page: 293 issue: 4 year: 2020 ident: 10.1016/j.jare.2022.12.007_b0060 article-title: Single-cell omics in ageing: a young and growing field publication-title: Nat Metab doi: 10.1038/s42255-020-0196-7 |
| SSID | ssj0000388911 |
| Score | 2.4782987 |
| Snippet | [Display omitted]
•The first single-cell transcriptomic atlases of testes of young and old mice were constructed.•Revealed aging-associated heterogenous... Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks of adverse... Introduction: Advanced paternal age of reproduction is an increasing trend, especially in developed countries and areas. This trend results in elevated risks... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 219 |
| SubjectTerms | Aging Inflammation Senescence Single-cell RNA sequencing Testis |
| SummonAdditionalLinks | – databaseName: ScienceDirect dbid: IXB link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYQJy5VgZYuLciVOBShaONn4lsBgRBSeylIe7NsZ4wWod3Vkv7_ehxnVQ5w4GrZsTMPz2Qy8w0hJyyqlkPHMM_PVVKqrvIckiwbSNbec69zr8Nfv_XNvbydqdkWuRxrYTCtstz9w52eb-syMi3UnK7m8-kfXpvsEHDMM2g1VpQL2eYivtnFJs6CaCcmt-HF-RUuKLUzQ5rXo1sjWibnOSqIXWX_s08Zxv-FmXrNDc3m6Poj-VD8SHo-HHWXbMFij-wWTX2mPwqc9Ok--XlOMR7wBBUG6WmPxilfFViPTHOpLyZB0WWkGAYA2iPwRk5PpbmF0Sdyf311d3lTlb4JVZBa91XrXJRe-NCA7oxvu05CEFGELqkYeCe9DmC6mncA0NQSWKKgN41XSd1BSvGZbC-WC_hCqOdRuCBd5DzKyBCvThos1uXK1aw1E8JGatlQQMWxt8WTHbPHHi1S2CKFLeM2UXhCzjZrVgOkxpuzL5AJm5kIh50HlusHW-TB6vSqpjYiquQfSgVt-uzzYGJoeGBMhAlRIwvtC-lKj5q_ufn3kd82qR2yyS0g8cLyBoHSsEfbhBwMgrA5otAK_0_Lw3fu-pXsYFP7oeLxG9nu13_hKLk-vT_Osv0PMvX-Dg priority: 102 providerName: Elsevier |
| Title | A single-cell transcriptomic landscape of mouse testicular aging |
| URI | https://dx.doi.org/10.1016/j.jare.2022.12.007 https://www.ncbi.nlm.nih.gov/pubmed/36528294 https://www.proquest.com/docview/2755581030 https://doaj.org/article/6c7e9093f532445e8495be9fc72c113c |
| Volume | 53 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA7iyYv4dn0RwYMixc2rbW4-UFTQk8LeQpJOQJFVtP5_Z9Lush7Ui5ce-gzzyEzSme9j7EAkU0toBNX5-UJr0xRBAtqyBYz2QYYycx3e3ZfXj_p2ZEYzVF9UE9bBA3eCOyljBRaX3clg6NcGaszoA9gUKxmFUJFmX4x5M4upPAeruraZfBcvUvmBkn3HTFfc9ezfCSNTyrwXSFyyM1Epg_d_C04_JZ85CF0tscU-e-Rn3aiX2RyMV9hy758f_LAHkT5aZadnnHYBXqCgrXneUkjKEwR1IfPc4EulT_w1cVr8A28JbiMXpfJMXLTGHq8uHy6ui54toYi6LNui9j7poALKq2xsqJtGQ1RJxQYdC4LXoYxgm6FsAKAaahDoIMFWwaCTg9Zqnc2PX8ewyXiQSfmofZIy6SQIpU5batGVxg9FbQdMTKTlYg8lTowWL25SM_bsSMKOJOyEdCjhATuePvPWAWn8evc5KWF6J4Fg5xNoGq43DfeXaQyYmajQ9flElyfgq55-_fj-RN8OnY3U5MeAunCyIng0YmYbsI3OEKZDVKWhv9J66z-Gvs0WiNe-a3rcYfPt-yfsYvbThr1s6Hi8GZ1_AUid_j4 |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5RemgvVelz-wBX6qFVFW3s2E58KyDQ0gKXgrQ3K3bGaBHaRdv0_9fjOKtyKAeuVpw4M2PPZDLzfQCfeVCNwI5TnV9bSKm6wgmMtmwwensnnE5ch2fnenYpf8zVfAsOx14YKqvMZ_9wpqfTOo9MszSnt4vF9JcoTQoIBNUZNLp-BI9jNFATf8PJ_GCTaCG4E5N4eGlCQTNy88xQ53XdrgkuU4iUFiRa2X8cVMLxv-On_heHJn90_Bye5UCS7Q9r3YEtXL6AnbxVf7MvGU_660v4vs8oIXCDBWXpWU_eKZ0V1JDMUq8vVUGxVWCUB0DWE_JGqk9licPoFVweH10czopMnFB4qXVfNG0bpKucr1F3xjVdJ9FXofJd3GPoWum0R9OVokPEupTIowidqZ2K-x2lrF7D9nK1xLfAnAhV62UbhAgycAKsk4a6dYVqS96YCfBRWtZnVHEit7ixY_nYtSUJW5Kw5cJGCU_g22bO7YCpce_VB6SEzZWEh50GVusrmw3C6viqpjRVUDFAlAqb-N3n0ARfC8955SegRhXaO-YVb7W49-GfRn3buO9ITe0Soy6sqAkpjUjaJvBmMITNEiut6Ae1fPfAp-7Bk9nF2ak9PTn_-R6eEsP90P74Abb79R_8GOOg3u0mO_8L_CQBPA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+single-cell+transcriptomic+landscape+of+mouse+testicular+aging&rft.jtitle=Journal+of+advanced+research&rft.au=Zhang%2C+Wei&rft.au=Xia%2C+Siyu&rft.au=Xiao%2C+Wei&rft.au=Song%2C+Yali&rft.date=2023-11-01&rft.issn=2090-1232&rft.volume=53&rft.spage=219&rft.epage=234&rft_id=info:doi/10.1016%2Fj.jare.2022.12.007&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jare_2022_12_007 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2090-1232&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2090-1232&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2090-1232&client=summon |