Epigenetic modulations in triple-negative breast cancer: Therapeutic implications for tumor microenvironment

• Published in: Pharmacological research Vol. 204; p. 107205
• Main Authors: Zhou, Linlin, Yu, Chen-Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2024; Elsevier
• Subjects: Epigenetic modulation and combination; Immunotherapy; Triple-negative breast cancer; Epigenetic modulation and combination; Immunotherapy; Triple-negative breast cancer; immunotherapy; epigenetic modulation and combination

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors, progesterone receptors and lacks HER2 overexpression. This absence of critical molecular targets poses significant challenges for conventional therapies. Immunotherapy, remarkably immune checkpoint blockade, of...