Vaginal distribution of Replens® and K-Y® Jelly using three imaging techniques

• Published in: Contraception (Stoneham) Vol. 77; no. 3; pp. 195 - 204
• Main Authors: Mauck, Christine K, Katz, David, Sandefer, Erik P, Nasution, Marlina D, Henderson, Marcus, Digenis, George A, Su, Irene, Page, Richard, Barnhart, Kurt
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2008; Elsevier Science
• Subjects: Administration, Intravaginal; Adult; Biological and medical sciences; Birth control; Body Mass Index; Cellulose - administration & dosage; Cellulose - analogs & derivatives; Cellulose - pharmacokinetics; Colposcopy - methods; Cross-Over Studies; Distribution; Emollients - administration & dosage; Emollients - pharmacokinetics; Female; Fiber Optic Technology; Fiberoptic; Genital system. Reproduction; Glycerol - administration & dosage; Glycerol - pharmacokinetics; Gynecology. Andrology. Obstetrics; Humans; Imaging; Lipids - administration & dosage; Lipids - pharmacokinetics; Magnetic Resonance Imaging; Medical sciences; Microbicide; MRI; Obstetrics and Gynecology; Other methods of contraception. Sterilization; Parity; Pharmacology. Drug treatments; Phosphates - administration & dosage; Phosphates - pharmacokinetics; Pregnancy; Propylene Glycols - administration & dosage; Propylene Glycols - pharmacokinetics; Radionuclide Imaging; Scintigraphy; Spreading; Time Factors; Tissue Distribution; Vagina; Vagina - diagnostic imaging; Vagina - metabolism; Vaginal Creams, Foams, and Jellies - pharmacokinetics; Walking; MRI; Spreading; Imaging; Distribution; Microbicide; Vagina; Fiberoptic; Scintigraphy; Intravaginal administration; Nuclear magnetic resonance imaging; Antimicrobial agent; Displacement; Colloidal gel; Body mass index; Dosage form; Medical imagery; Commercial form; Pharmacokinetics; Parity; Comparative study

Abstract Background Determination of vaginal distribution is important to the development of potential vaginal microbicidal or spermicidal products. Study Design This was a descriptive study of three imaging techniques with a randomized crossover assignment of two gels and activity status within eac...