Decentralised clinical trials in multiple sclerosis research
Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robustness of their designs and the efficiency of their...
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| Published in | Multiple Sclerosis Journal Vol. 29; no. 3; pp. 317 - 325 |
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| Main Authors | , , , , , , , , , , |
| Format | Book Review Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.03.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robustness of their designs and the efficiency of their conduct. Advances in digital and mobile technologies in recent years have facilitated this process and the first RCTs with decentralised elements became possible. Decentralised clinical trials (DCTs) are conducted remotely, enabling participation of a more heterogeneous population who can participate in research activities from different locations and at their convenience. DCTs also rely on digital and mobile technologies which allows for more flexible and frequent assessments. While hospitals quickly adapted to e-health and telehealth assessments during the COVID-19 pandemic, the conduct of conventional RCTs was profoundly disrupted. In this paper, we review the existing evidence and gaps in knowledge in the design and conduct of DCTs in MS. |
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| AbstractList | Randomised controlled trials (RCTs) play an important role in multiple sclerosis (MS) research, ensuring that new interventions are safe and efficacious before their introduction into clinical practice. Trials have been evolving to improve the robustness of their designs and the efficiency of their conduct. Advances in digital and mobile technologies in recent years have facilitated this process and the first RCTs with decentralised elements became possible. Decentralised clinical trials (DCTs) are conducted remotely, enabling participation of a more heterogeneous population who can participate in research activities from different locations and at their convenience. DCTs also rely on digital and mobile technologies which allows for more flexible and frequent assessments. While hospitals quickly adapted to e-health and telehealth assessments during the COVID-19 pandemic, the conduct of conventional RCTs was profoundly disrupted. In this paper, we review the existing evidence and gaps in knowledge in the design and conduct of DCTs in MS. |
| Author | Garjani, Afagh Tallantyre, Emma C das Nair, Roshan Evangelou, Nikos Planchon, Sarah Marie Gerry, Stephen William Gunzler, Douglas David Liu, Brandon Jun-Yu Allen, Christopher Martin Chataway, Jeremy Ontaneda, Daniel |
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| Keywords | clinical trial digital randomised controlled trial Decentralised remote multiple sclerosis |
| Language | English |
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| Title | Decentralised clinical trials in multiple sclerosis research |
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