Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists

• Published in: Bioorganic & medicinal chemistry letters Vol. 29; no. 16; pp. 2124 - 2128
• Main Authors: Miyachi, Hiroyuki, Yuzuriha, Tomohiro, Tabata, Ryotaro, Fukuda, Syohei, Nunomura, Kazuto, Lin, Bangzhong, Kobayashi, Tadayuki, Ishimoto, Kenji, Doi, Takefumi, Tachibana, Keisuke
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.08.2019; Elsevier
• Subjects: 1H-Pyrazolo-[3,4-b]pyridine-4-carboxylic acid; Agonist; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Life Sciences & Biomedicine; Peroxisome proliferator-activated receptor alpha; Pharmacology & Pharmacy; Physical Sciences; PPAR; PPARα agonist; Science & Technology; Structure-activity relationship; Peroxisome proliferator-activated receptor alpha; 1H-Pyrazolo-[3,4-b]pyridine-4-carboxylic acid; Agonist; PPAR; PPARα agonist; Structure-activity relationship; PPAR alpha agonist; PPAR-ALPHA; METABOLISM; BINDING; STRUCTURE-BASED DESIGN

[Display omitted] We previously reported that 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivative 6 is an agonist of human peroxisome proliferator-activated receptor alpha (hPPARα). Here, we prepared a series of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives in order to examine the s...