A new qualitative pattern classification of shear wave elastograghy for solid breast mass evaluation

• Published in: European journal of radiology Vol. 87; pp. 111 - 119
• Main Authors: Cong, Rui, Li, Jing, Guo, Song
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2017
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy, Large-Core Needle; Breast; Breast - diagnostic imaging; Breast - pathology; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Diagnosis; Elasticity Imaging Techniques - methods; Female; Humans; Imaging techniques; Middle Aged; Prospective Studies; Radiology; Reproducibility of Results; Sensitivity and Specificity; Shear wave elastography; Ultrasonography, Mammary - methods; Ultrasound; Young Adult; SWE; Shear wave elastography; ROC; Imaging techniques; BI-RADS; ROI; Qual1; Qual2; ACR; NPV; PPV; Breast; Diagnosis; Ultrasound; US; positive predictive value; American College of Radiology; region-of-interest; ultrasound; qualitative classification 1; qualitative classification 2; breast imaging reporting and data system; receiver operating characteristic; negative predictive value; shear wave elastography
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2016.12.021

•Qualitative SWE classification proposed here was significantly better than quantitative SWE parameters.•Qualitative classification proposed here was better than the classification proposed before.•Qualitative classification proposed here could obtain higher specificity without a loss of sensitivity. To examine the efficacy of qualitative shear wave elastography (SWE) in the classification and evaluation of solid breast masses, and to compare this method with conventional ultrasonograghy (US), quantitative SWE parameters and qualitative SWE classification proposed before. From April 2015 to March 2016, 314 consecutive females with 325 breast masses who decided to undergo core needle biopsy and/or surgical biopsy were enrolled. Conventional US and SWE were previously performed in all enrolled subjects. Each mass was classified by two different qualitative classifications. One was established in our study, herein named the Qual1. Qual1 could classify the SWE images into five color patterns by the visual evaluations: Color pattern 1 (homogeneous pattern); Color pattern 2 (comparative homogeneous pattern); Color pattern 3 (irregularly heterogeneous pattern); Color pattern 4 (intralesional echo pattern); and Color pattern 5 (the stiff rim sign pattern). The second qualitative classification was named Qual2 here, and included a four-color overlay pattern classification (Tozaki and Fukuma, Acta Radiologica, 2011). The Breast Imaging Reporting and Data System (BI-RADS) assessment and quantitative SWE parameters were recorded. Diagnostic performances of conventional US, SWE parameters, and combinations of US and SWE parameters were compared. With pathological results as the gold standard, of the 325 examined breast masses, 139 (42.77%) samples were malignant and 186 (57.23%) were benign. The Qual1 showed a higher Az value than the Qual2 and quantitative SWE parameters (all P<0.05). When applying Qual1=Color pattern 1 for downgrading and Qual1=Color pattern 5 for upgrading the BI-RADS categories, we obtained the highest Az value (0.951), and achieved a significantly higher specificity (86.56%, P=0.002) than that of the US (81.18%) with the same sensitivity (94.96%). The qualitative classification proposed in this study may be representative of SWE parameters and has potential to be relevant assistance in breast mass diagnoses.