Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

• Published in: Cell metabolism Vol. 33; no. 12; pp. 2398 - 2414.e9
• Main Authors: Willenborg, Sebastian, Sanin, David E., Jais, Alexander, Ding, Xiaolei, Ulas, Thomas, Nüchel, Julian, Popović, Milica, MacVicar, Thomas, Langer, Thomas, Schultze, Joachim L., Gerbaulet, Alexander, Roers, Axel, Pearce, Edward J., Brüning, Jens C., Trifunovic, Aleksandra, Eming, Sabine A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.12.2021
• Subjects: Animals; Macrophages - metabolism; metabolism; Mice; mitochondria; Mitochondria - metabolism; mitochondrial repurposing; mitohormesis; monocyte/macrophage; tissue repair; type 2 immunity; Wound Healing; wound healing; mitochondria; mitochondrial repurposing; metabolism; mitohormesis; monocyte/macrophage; type 2 immunity; tissue repair

Wound healing is a coordinated process that initially relies on pro-inflammatory macrophages, followed by a pro-resolution function of these cells. Changes in cellular metabolism likely dictate these distinct activities, but the nature of these changes has been unclear. Here, we profiled early- vers...