Identification of a LncRNA based CeRNA network signature to establish a prognostic model and explore potential therapeutic targets in gastric cancer

• Published in: Scientific reports Vol. 15; no. 1; pp. 20891 - 15
• Main Authors: An, Yuanqing, Liu, Xiaomeng, Liu, Jin, Wang, Deqiang, Yan, Wenying, Hu, Guang, Xu, Lu, Li, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Portfolio
• Subjects: 631/67; 692/53; Animals; Biomarkers, Tumor - genetics; Cell Line, Tumor; Female; Gastric cancer; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humanities and Social Sciences; Humans; Immunotherapy; LncRNA; Male; MicroRNAs - genetics; Middle Aged; multidisciplinary; Prognosis; Prognostic model; RNA, Competitive Endogenous; RNA, Long Noncoding - genetics; RNA, Messenger - genetics; Science; Science (multidisciplinary); Stomach Neoplasms - genetics; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Tumor microenvironment; WGCNA; LncRNA; Prognostic model; Tumor microenvironment; Gastric cancer; WGCNA; Immunotherapy

Numerous studies have demonstrated that long non-coding RNA (lncRNA) play critical roles in regulating physiological processes and contributing to pathological diseases. This study aimed to develop lncRNA-based signatures to predict the prognostic risk of gastric cancer (GC) patients and provide the...