NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice

• Published in: Molecular pain Vol. 17; p. 17448069211018045
• Main Authors: Xue, Man, Zhou, Si-Bo, Liu, Ren-Hao, Chen, Qi-Yu, Zhuo, Min, Li, Xu-Hui
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2021; Sage Publications Ltd
• Subjects: Animals; Chronic pain; Cortex (cingulate); Depression; Drug therapy; Electric Stimulation; Glutamic acid receptors (ionotropic); Gyrus Cinguli - metabolism; Long-term depression; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; N-Methyl-D-aspartic acid receptors; Pain; Pain perception; Receptors, N-Methyl-D-Aspartate - metabolism; Synapses - metabolism; Synaptic depression; Synaptic plasticity; ACC; Synaptic plasticity; LFS; LTP; NMDA receptors; synaptic depression; LTD

Long-term potentiation (LTP) is an important molecular mechanism for chronic pain in the anterior cingulate cortex (ACC), a key cortical region for pain perception and emotional regulation. Inhibiting ACC LTP via various manipulations or pharmacological treatments blocks chronic pain. Long-term depr...