Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children
This study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical features of primary nephrotic syndrome (NS) in children. Thirty-six children with primary NS were selected as case group, and 94 he...
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Published in | Life sciences (1973) Vol. 118; no. 2; pp. 446 - 450 |
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Language | English |
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Abstract | This study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical features of primary nephrotic syndrome (NS) in children.
Thirty-six children with primary NS were selected as case group, and 94 healthy children were selected as control group. All subjects were genotyped for three single nucleotide polymorphisms (SNPs) (rs5370, rs10478694 [3A4A] and rs 1630736) in the ET-1 gene by gene sequencing. The plasma ET-1 concentrations were measured using a radio-immunoassay.
Plasma ET-1 concentrations were higher in NS patients (P=0.007) as compared to healthy children. The allele frequencies between control and NS patients were significantly different only with respect to the rs10478694 SNP of the ET-1 gene. The allele frequencies between control and NS patients for the rs5370 SNP showed a trend towards difference (P=0.057). Plasma cholesterol in NS patients is associated with both: the GT genotype in locus rs5370 and the 3A4A genotype in locus rs10478694 (P<0.05 in both cases).
The ET systems might play a disease modifying role in pediatric NS. Plasma cholesterol, a hallmark of NS, seems to be associated with genetic variations within the human ET-1 gene.
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AbstractList | This study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical features of primary nephrotic syndrome (NS) in children.
Thirty-six children with primary NS were selected as case group, and 94 healthy children were selected as control group. All subjects were genotyped for three single nucleotide polymorphisms (SNPs) (rs5370, rs10478694 [3A4A] and rs 1630736) in the ET-1 gene by gene sequencing. The plasma ET-1 concentrations were measured using a radio-immunoassay.
Plasma ET-1 concentrations were higher in NS patients (P=0.007) as compared to healthy children. The allele frequencies between control and NS patients were significantly different only with respect to the rs10478694 SNP of the ET-1 gene. The allele frequencies between control and NS patients for the rs5370 SNP showed a trend towards difference (P=0.057). Plasma cholesterol in NS patients is associated with both: the GT genotype in locus rs5370 and the 3A4A genotype in locus rs10478694 (P<0.05 in both cases).
The ET systems might play a disease modifying role in pediatric NS. Plasma cholesterol, a hallmark of NS, seems to be associated with genetic variations within the human ET-1 gene. AIMSThis study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical features of primary nephrotic syndrome (NS) in children.MATERIALS AND METHODSThirty-six children with primary NS were selected as case group, and 94 healthy children were selected as control group. All subjects were genotyped for three single nucleotide polymorphisms (SNPs) (rs5370, rs10478694 [3A4A] and rs 1630736) in the ET-1 gene by gene sequencing. The plasma ET-1 concentrations were measured using a radio-immunoassay.KEY FINDINGSPlasma ET-1 concentrations were higher in NS patients (P=0.007) as compared to healthy children. The allele frequencies between control and NS patients were significantly different only with respect to the rs10478694 SNP of the ET-1 gene. The allele frequencies between control and NS patients for the rs5370 SNP showed a trend towards difference (P=0.057). Plasma cholesterol in NS patients is associated with both: the GT genotype in locus rs5370 and the 3A4A genotype in locus rs10478694 (P<0.05 in both cases).SIGNIFICANCEThe ET systems might play a disease modifying role in pediatric NS. Plasma cholesterol, a hallmark of NS, seems to be associated with genetic variations within the human ET-1 gene. This study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical features of primary nephrotic syndrome (NS) in children. Thirty-six children with primary NS were selected as case group, and 94 healthy children were selected as control group. All subjects were genotyped for three single nucleotide polymorphisms (SNPs) (rs5370, rs10478694 [3A4A] and rs 1630736) in the ET-1 gene by gene sequencing. The plasma ET-1 concentrations were measured using a radio-immunoassay. Plasma ET-1 concentrations were higher in NS patients (P=0.007) as compared to healthy children. The allele frequencies between control and NS patients were significantly different only with respect to the rs10478694 SNP of the ET-1 gene. The allele frequencies between control and NS patients for the rs5370 SNP showed a trend towards difference (P=0.057). Plasma cholesterol in NS patients is associated with both: the GT genotype in locus rs5370 and the 3A4A genotype in locus rs10478694 (P<0.05 in both cases). The ET systems might play a disease modifying role in pediatric NS. Plasma cholesterol, a hallmark of NS, seems to be associated with genetic variations within the human ET-1 gene. [Display omitted] |
Author | Deng, Li Hocher, Berthold Zeng, Shuixiu Zhang, Cheng Hocher, Carl-Friedrich Yang, Fang Lai, Xinlong Li, Jian Liu, Xiaoxiao |
Author_xml | – sequence: 1 givenname: Fang surname: Yang fullname: Yang, Fang email: tyf@jnu.edu.cn organization: Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China – sequence: 2 givenname: Xinlong surname: Lai fullname: Lai, Xinlong organization: Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China – sequence: 3 givenname: Li surname: Deng fullname: Deng, Li organization: Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China – sequence: 4 givenname: Xiaoxiao surname: Liu fullname: Liu, Xiaoxiao organization: Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China – sequence: 5 givenname: Jian surname: Li fullname: Li, Jian organization: Department of Clinical Medicine, Medical college of Hunan Normal University, Changsha, China – sequence: 6 givenname: Shuixiu surname: Zeng fullname: Zeng, Shuixiu organization: Department of Pediatrics, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China – sequence: 7 givenname: Cheng surname: Zhang fullname: Zhang, Cheng organization: Department of Pediatrics, Zhuhai Hospital of Jinan University, Zhuhai, Guangdong, China – sequence: 8 givenname: Carl-Friedrich surname: Hocher fullname: Hocher, Carl-Friedrich organization: Institute of Nutritional Science, University of Potsdam, Germany and Jinan University, Guangzhou, China – sequence: 9 givenname: Berthold surname: Hocher fullname: Hocher, Berthold email: hocher@uni-potsdam.de organization: Institute of Nutritional Science, University of Potsdam, Germany and Jinan University, Guangzhou, China |
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Keywords | Childhood nephrotic syndrome Gene polymorphism Cholesterol Endothelin-1 |
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Snippet | This study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and... AIMSThis study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A... |
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SubjectTerms | Blood Urea Nitrogen Case-Control Studies Child Childhood nephrotic syndrome Cholesterol Creatinine - blood Endothelin-1 Endothelin-1 - genetics Female Gene Frequency Gene polymorphism Genetic Predisposition to Disease Humans Male Nephrotic Syndrome - blood Nephrotic Syndrome - genetics Nephrotic Syndrome - urine Phenotype Polymorphism, Single Nucleotide - genetics |
Title | Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children |
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