A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma

• Published in: Scientific reports Vol. 15; no. 1; pp. 21064 - 13
• Main Authors: Amaral, L. J., Gresham, Gillian, Kim, Sungjin, Tighiouart, Mourad, Nelson, Thomas A., Welborn, Amelia, Lockshon, Laura, Noorvash, Brandon, Rudnick, Jeremy D., Irwin, Scott A., Freedland, Stephen J., Hu, Jethro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Portfolio
• Subjects: 631/67; 631/67/1922; 631/67/2327; 692/4028; Adult; Aged; Brain Neoplasms - diet therapy; Brain Neoplasms - mortality; Brain Neoplasms - therapy; Cancer metabolism; Diet, Ketogenic - adverse effects; Diet, Ketogenic - methods; Feasibility Studies; Female; Glioblastoma; Glioblastoma - diagnosis; Glioblastoma - diet therapy; Glioblastoma - mortality; Glioblastoma - therapy; Humanities and Social Sciences; Humans; Ketogenic diets; Ketosis; Male; Middle Aged; multidisciplinary; Quality of Life; Science; Science (multidisciplinary); Standard of Care; Supportive care; Treatment Outcome; Warburg effect; Ketogenic diets; Cancer metabolism; Physical activity; Glioblastoma; Supportive care; Ketosis; Warburg effect; Quality of life

Despite great interest, there is limited clinical evidence to support the use of a ketogenic diet (KD) for cancer patients. We conducted a single-arm phase 1 trial of a KD among patients with recently diagnosed glioblastoma (GBM) receiving standard-of-care (SOC) treatment. Adults with GBM within 3 m...