Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS

• Published in: Acta pharmaceutica Sinica. B Vol. 14; no. 5; pp. 2039 - 2056
• Main Authors: Yu, Pei, Han, Yubao, Meng, Lulu, Tian, Yanyuan, Jin, Zhiwei, Luo, Jun, Han, Chao, Xu, Wenjun, Kong, Lingyi, Zhang, Chao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.05.2024
• Subjects: Epithelial–mesenchymal transition; Exosome; Lung metastasis; Lung–bone transmission; miR-194/215 cluster; Vasculogenic mimicry; Bioengineered exosome mimetics; Lung metastasis; Exosome; Osteosarcoma; Epithelial–mesenchymal transition; miR-194/215 cluster; Lung–bone transmission; Vasculogenic mimicry

Osteosarcoma, a prevalent primary malignant bone tumor, often presents with lung metastases, severely impacting patient survival rates. Extracellular vesicles, particularly exosomes, play a pivotal role in the formation and progression of osteosarcoma-related pulmonary lesions. However, the communic...