High Level of Chemokine CCL18 Is Associated With Pulmonary Function Deterioration, Lung Fibrosis Progression, and Reduced Survival in Systemic Sclerosis

• Published in: Chest Vol. 150; no. 2; p. 299
• Main Authors: Hoffmann-Vold, Anna-Maria, Tennøe, Anders Heiervang, Garen, Torhild, Midtvedt, Øyvind, Abraityte, Aurelija, Aaløkken, Trond Mogens, Lund, May Britt, Brunborg, Cathrine, Aukrust, Pål, Ueland, Thor, Molberg, Øyvind
• Format: Journal Article
• Language: English
• Published: United States 01.08.2016
• Subjects: Adult; Aged; Case-Control Studies; Chemokines, CC - immunology; Cohort Studies; Disease Progression; Female; Humans; Lung - physiopathology; Lung Diseases, Interstitial - etiology; Lung Diseases, Interstitial - immunology; Lung Diseases, Interstitial - mortality; Lung Diseases, Interstitial - physiopathology; Male; Middle Aged; Norway; Prognosis; Prospective Studies; Pulmonary Fibrosis - etiology; Pulmonary Fibrosis - immunology; Pulmonary Fibrosis - mortality; Pulmonary Fibrosis - physiopathology; Respiratory Function Tests; Scleroderma, Systemic - complications; Scleroderma, Systemic - immunology; Scleroderma, Systemic - mortality; Scleroderma, Systemic - physiopathology; Survival Rate; Vital Capacity; interstitial lung disease; scleroderma; cytokines

Markers for early identification of progressive interstitial lung disease (ILD) in systemic sclerosis (SSc) are in demand. Chemokine CCL18, which has been linked to pulmonary inflammation, is an interesting candidate, but data have not been consistent. We aimed to assess CCL18 levels in a large, pro...