Association between bipolar disorder and diabetic ketoacidosis/hyperosmolar hyperglycemic state

• Published in: Scientific reports Vol. 15; no. 1; pp. 22701 - 10
• Main Authors: Liu, Han-Jung, Lo, Shih-Chang, Huang, Chien-Ning, Yang, Yi-Sun, Wang, Yu-Hsun, Kornelius, Edy
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.07.2025; Nature Portfolio
• Subjects: 692/308; 692/699/2743; Adult; Aged; Bipolar; Bipolar Disorder - complications; Bipolar Disorder - epidemiology; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetic Ketoacidosis - complications; Diabetic Ketoacidosis - epidemiology; Diabetic Ketoacidosis - etiology; DKA; Female; HHS; Humanities and Social Sciences; Humans; Hyperglycemia; Hyperglycemic Hyperosmolar Nonketotic Coma - epidemiology; Incidence; Male; Middle Aged; multidisciplinary; Retrospective Studies; Risk Factors; Science; Science (multidisciplinary); Bipolar; HHS; Diabetes; DKA
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-025-08087-y

Individuals with bipolar disorder have a higher prevalence of type 2 diabetes mellitus (T2DM) and are at increased risk for diabetes-related complications. However, little is known about the association between bipolar disorder and acute hyperglycemic crises, including diabetic ketoacidosis (DKA) an...