Liraglutide attenuates obese-associated breast cancer cell proliferation via inhibiting PI3K/Akt/mTOR signaling pathway

• Published in: Saudi pharmaceutical journal Vol. 32; no. 1; p. 101923
• Main Authors: Alanteet, Alaa, Attia, Hala, Alfayez, Musaed, Mahmood, Amer, Alsaleh, Khalid, Alsanea, Sary
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.01.2024; Springer
• Subjects: Akt; Breast Cancer; Liraglutide; mTOR; Obesity; PI3K; PBS; Obesity; BC; CM; siRNA; Akt; ADSCs-CM; Breast Cancer; SC; BSA; DMEM; SIRT-1; p-Akt; PI3K; ADSCs; FBS; mTOR; LGT; AMPK; Liraglutide; BMI; GLP-1R

This study aims to explore the anti-proliferative, pro-apoptotic, and anti-migration activities of liraglutide (LGT) in MCF-7 breast cancer (BC) cells in subjects with obesity, particularly its effects on the PI3K/Akt/mTOR/AMPK pathway. The role of AMPK/SIRT-1, an essential regulator of adipokine pr...