Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis

• Published in: Cell stem cell Vol. 15; no. 6; pp. 791 - 804
• Main Authors: Sánchez-Aguilera, Abel, Arranz, Lorena, Martín-Pérez, Daniel, García-García, Andrés, Stavropoulou, Vaia, Kubovcakova, Lucia, Isern, Joan, Martín-Salamanca, Sandra, Langa, Xavier, Skoda, Radek C., Schwaller, Jürg, Méndez-Ferrer, Simón
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.12.2014
• Subjects: Animals; Apoptosis - drug effects; Apoptosis - genetics; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cell Proliferation - drug effects; Cell Proliferation - genetics; Cells, Cultured; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Hematopoiesis - drug effects; Hematopoiesis - genetics; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells - drug effects; Hematopoietic Stem Cells - physiology; Humans; Janus Kinase 2 - genetics; Janus Kinase 2 - metabolism; Leukemia - drug therapy; Leukemia - metabolism; Leukemia - pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation - genetics; Myeloid Progenitor Cells - drug effects; Myeloid Progenitor Cells - physiology; Oncogene Proteins, Fusion - metabolism; Selective Estrogen Receptor Modulators - administration & dosage; Signal Transduction; Tamoxifen - administration & dosage; Xenograft Model Antitumor Assays

Estrogens are potent regulators of mature hematopoietic cells; however, their effects on primitive and malignant hematopoietic cells remain unclear. Using genetic and pharmacological approaches, we observed differential expression and function of estrogen receptors (ERs) in hematopoietic stem cell (...