The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: A randomized controlled trial
Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects. Fifty subjects were randomized to...
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| Published in | Prostaglandins, leukotrienes and essential fatty acids Vol. 87; no. 1; pp. 43 - 48 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Scotland
Elsevier Ltd
01.07.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0952-3278 1532-2823 1532-2823 |
| DOI | 10.1016/j.plefa.2012.05.009 |
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| Abstract | Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects.
Fifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks.
Leukotriene B4 formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B5 increased significantly compared to the control group (p<0.001).
In conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1g marine n-3 PUFA for 6 weeks. |
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| AbstractList | Abstract Introduction Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects. Materials and methods Fifty subjects were randomized to 1.1 g of n-3 PUFA or olive oil for 6 weeks. Results Leukotriene B4 formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group ( p =0.005) but not between groups ( p =0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B5 increased significantly compared to the control group ( p <0.001). Conclusion In conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1 g marine n-3 PUFA for 6 weeks. Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects.INTRODUCTIONMarine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects.Fifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks.MATERIALS AND METHODSFifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks.Leukotriene B(4) formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B(5) increased significantly compared to the control group (p<0.001).RESULTSLeukotriene B(4) formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B(5) increased significantly compared to the control group (p<0.001).In conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1g marine n-3 PUFA for 6 weeks.CONCLUSIONIn conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1g marine n-3 PUFA for 6 weeks. Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects. Fifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks. Leukotriene B4 formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B5 increased significantly compared to the control group (p<0.001). In conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1g marine n-3 PUFA for 6 weeks. Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects. Fifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks. Leukotriene B(4) formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B(5) increased significantly compared to the control group (p<0.001). In conclusion, we did not observe any significant net anti-inflammatory effect on the 5-lipoxygenase pathway from a daily supplement of 1.1g marine n-3 PUFA for 6 weeks. |
| Author | Schmidt, E.B. Aardestrup, I. Madsen, T. Nielsen, M.S. Gammelmark, A. Obel, T. |
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| Cites_doi | 10.2459/01.JCM.0000289269.98105.65 10.1016/j.clnu.2008.10.012 10.1046/j.1464-5491.2001.00410.x 10.1172/JCI111612 10.1097/01.hjr.0000277983.23934.c9 10.1007/BF02562283 10.1016/S0021-9258(18)98347-X 10.1007/s11745-999-0369-5 10.1074/jbc.M203194200 10.1074/jbc.M109.004861 10.1017/S0007114508923692 10.1016/j.nutres.2011.12.007 10.1161/01.ATV.0000057393.97337.AE 10.1093/ajcn/83.2.456S 10.1136/bmj.311.6998.158 10.1016/0090-6980(84)90075-3 10.1056/NEJM198505093121903 10.1016/0748-5514(85)90121-7 10.1097/MCO.0b013e32834777fa 10.1016/S0022-2275(20)41095-8 10.1378/chest.129.1.39 10.1161/01.CIR.0000052939.59093.45 10.1111/j.1365-2362.2010.02371.x 10.1038/sj.ki.5000291 10.1124/jpet.109.157891 10.1007/s10557-008-6140-9 10.1159/000419307 10.4049/jimmunol.178.6.3912 10.1007/BF00915380 10.1016/j.plefa.2011.04.004 |
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| Keywords | Leukotrienes Marine n-3 polyunsaturated fatty acids 5-Lipoxygenase |
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| References | Lean, Han, Morrison (bib16) 1995; 311 Hosoi, Koguchi, Sugikawa, Chikada, Ogawa, Tsuda (bib29) 2002; 277 Mickleborough, Lindley, Ionescu, Fly (bib13) 2006; 129 Giouleka, Papatheodorou, Lyberopoulos, Karakatsani, Alchanatis, Roussos (bib32) 2011; 41 Graham, Atar, Borch-Johnsen, Boysen, Burell, Cifkova (bib1) 2007; 14 van Kuijk, Thomas, Stephens, Dratz (bib17) 1985; 1 Moreno (bib22) 2009; 331 Sperling (bib19) 1991; 66 National Food Institute—Technical University of Denmark (DTU). Available from Mickleborough, Tecklenburg, Montgomery, Lindley (bib24) 2009; 28 Heidel, Taylor, Laegreid, Silflow, Liggitt, Leid (bib27) 1989; 134 Taccone-Gallucci, Manca-di-Villahermosa, Battistini, Stuffler, Tedesco, Maccarrone (bib25) 2006; 69 Martinez-Clemente, Claria, Titos. (bib5) 2011; 14 Gammelmark, Madsen, Varming, Lundbye-Christensen, Schmidt (bib14) 2012; 32 Terano, Salmon, Moncada (bib23) 1984; 27 Kelley, Taylor, Nelson, Schmidt, Ferretti, Erickson (bib8) 1999; 34 Lee, Mencia-Huerta, Shih, Corey, Lewis, Austen (bib30) 1984; 74 Libby (bib3) 2006; 83 Lossl, Skou, Christensen, Schmidt. (bib9) 1999; 34 Arita, Ohira, Sun, Elangovan, Chiang, Serhan. (bib34) 2007; 178 Pearson, Mensah, Alexander, Anderson, Cannon, Criqui (bib33) 2003; 107 Masson, Latini, Tacconi, Bernasconi (bib21) 2007; 8 Back. (bib4) 2009; 23 Payan, Wong, Chernov-Rogan, Valone, Pickett, Blake (bib11) 1986; 6 Kris-Etherton, Harris, Appel, AHA Nutrition Committee, American Heart Association (bib2) 2003; 23 . Lee, Hoover, Williams, Sperling, Ravalese, Spur (bib12) 1985; 312 Massaro, Scoditti, Carluccio, Campana, De Caterina. (bib20) 2010; 56 Powell, Gravel, Gravelle (bib31) 1995; 36 Stanke-Labesque, Moliere, Bessard, Laville, Vericel, Lagarde (bib7) 2008; 100 Sampson, Davies, Brown, Morgan, Richardson, James (bib10) 2001; 18 Maaloe, Schmidt, Svensson, Aardestrup, Christensen. (bib26) 2011; 85 Weaver, Ivester, Seeds, Case, Arm, Chilton (bib6) 2009; 284 Report of IUPAC Working Group (bib18) 1987 Powell, Gravel, MacLeod, Mills, Hashefi (bib28) 1993; 268 10.1016/j.plefa.2012.05.009_bib15 Mickleborough (10.1016/j.plefa.2012.05.009_bib24) 2009; 28 Maaloe (10.1016/j.plefa.2012.05.009_bib26) 2011; 85 Weaver (10.1016/j.plefa.2012.05.009_bib6) 2009; 284 Report of IUPAC Working Group (10.1016/j.plefa.2012.05.009_bib18) 1987 Masson (10.1016/j.plefa.2012.05.009_bib21) 2007; 8 Sampson (10.1016/j.plefa.2012.05.009_bib10) 2001; 18 Massaro (10.1016/j.plefa.2012.05.009_bib20) 2010; 56 Kris-Etherton (10.1016/j.plefa.2012.05.009_bib2) 2003; 23 Back. (10.1016/j.plefa.2012.05.009_bib4) 2009; 23 Hosoi (10.1016/j.plefa.2012.05.009_bib29) 2002; 277 Libby (10.1016/j.plefa.2012.05.009_bib3) 2006; 83 Lee (10.1016/j.plefa.2012.05.009_bib12) 1985; 312 Powell (10.1016/j.plefa.2012.05.009_bib31) 1995; 36 Stanke-Labesque (10.1016/j.plefa.2012.05.009_bib7) 2008; 100 Lossl (10.1016/j.plefa.2012.05.009_bib9) 1999; 34 Kelley (10.1016/j.plefa.2012.05.009_bib8) 1999; 34 Lee (10.1016/j.plefa.2012.05.009_bib30) 1984; 74 van Kuijk (10.1016/j.plefa.2012.05.009_bib17) 1985; 1 Graham (10.1016/j.plefa.2012.05.009_bib1) 2007; 14 Martinez-Clemente (10.1016/j.plefa.2012.05.009_bib5) 2011; 14 Taccone-Gallucci (10.1016/j.plefa.2012.05.009_bib25) 2006; 69 Arita (10.1016/j.plefa.2012.05.009_bib34) 2007; 178 Terano (10.1016/j.plefa.2012.05.009_bib23) 1984; 27 Sperling (10.1016/j.plefa.2012.05.009_bib19) 1991; 66 Gammelmark (10.1016/j.plefa.2012.05.009_bib14) 2012; 32 Moreno (10.1016/j.plefa.2012.05.009_bib22) 2009; 331 Mickleborough (10.1016/j.plefa.2012.05.009_bib13) 2006; 129 Pearson (10.1016/j.plefa.2012.05.009_bib33) 2003; 107 Heidel (10.1016/j.plefa.2012.05.009_bib27) 1989; 134 Powell (10.1016/j.plefa.2012.05.009_bib28) 1993; 268 Payan (10.1016/j.plefa.2012.05.009_bib11) 1986; 6 Lean (10.1016/j.plefa.2012.05.009_bib16) 1995; 311 Giouleka (10.1016/j.plefa.2012.05.009_bib32) 2011; 41 |
| References_xml | – volume: 6 start-page: 402 year: 1986 end-page: 410 ident: bib11 article-title: Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid publication-title: J. Clin. Immunol. – volume: 32 start-page: 15 year: 2012 end-page: 23 ident: bib14 article-title: Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects publication-title: Nutr. Res. – volume: 134 start-page: 671 year: 1989 end-page: 676 ident: bib27 article-title: In vivo chemotaxis of bovine neutrophils induced by 5-lipoxygenase metabolites of arachidonic and eicosapentaenoic acid publication-title: Am. J. Pathol. – volume: 277 start-page: 31459 year: 2002 end-page: 31465 ident: bib29 article-title: Identification of a novel human eicosanoid receptor coupled to G(i/o) publication-title: J. Biol. Chem. – volume: 23 start-page: 41 year: 2009 end-page: 48 ident: bib4 article-title: Leukotriene signaling in atherosclerosis and ischemia publication-title: Cardiovasc. Drugs Ther. – volume: 41 start-page: 30 year: 2011 end-page: 38 ident: bib32 article-title: Body mass index is associated with leukotriene inflammation in asthmatics publication-title: Eur. J. Clin. Invest. – volume: 311 start-page: 158 year: 1995 end-page: 161 ident: bib16 article-title: Waist circumference as a measure for indicating need for weight management publication-title: Br. Med. J. – volume: 28 start-page: 71 year: 2009 end-page: 77 ident: bib24 article-title: Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells publication-title: Clin. Nutr. – volume: 36 start-page: 2590 year: 1995 end-page: 2598 ident: bib31 article-title: Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils publication-title: J. Lipid Res. – volume: 312 start-page: 1217 year: 1985 end-page: 1224 ident: bib12 article-title: Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function publication-title: N. Engl. J. Med. – volume: 85 start-page: 37 year: 2011 end-page: 41 ident: bib26 article-title: The effect of n-3 polyunsaturated fatty acids on leukotriene B(4) and leukotriene B(5) production from stimulated neutrophil granulocytes in patients with chronic kidney disease publication-title: Prostaglandins Leukot. Essent. Fatty Acids – volume: 268 start-page: 9280 year: 1993 end-page: 9286 ident: bib28 article-title: Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor publication-title: J. Biol. Chem. – year: 1987 ident: bib18 publication-title: IUPAC Method 2.301. IUPAC Standard Methods for Analysis of Oils, Fats and Derivatives – volume: 66 start-page: 391 year: 1991 end-page: 400 ident: bib19 article-title: Effects of dietary fish oil on leukocyte leukotriene and PAF generation and on neutrophil chemotaxis publication-title: World Rev. Nutr. Diet. – volume: 129 start-page: 39 year: 2006 end-page: 49 ident: bib13 article-title: Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma publication-title: Chest – volume: 14 start-page: 347 year: 2011 end-page: 353 ident: bib5 article-title: The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease publication-title: Curr. Opin. Clin. Nutr. Metab. Care – volume: 23 start-page: 151 year: 2003 end-page: 152 ident: bib2 article-title: Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 74 start-page: 1922 year: 1984 end-page: 1933 ident: bib30 article-title: Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils publication-title: J. Clin. Invest. – volume: 100 start-page: 829 year: 2008 end-page: 833 ident: bib7 article-title: Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers publication-title: Br. J. Nutr. – reference: National Food Institute—Technical University of Denmark (DTU). Available from: – volume: 34 start-page: S185 year: 1999 ident: bib9 article-title: The effect of n-3 fatty acids on leukotriene formation from neutrophils in patients on hemodialysis publication-title: Lipids – reference: . – volume: 69 start-page: 1450 year: 2006 end-page: 1454 ident: bib25 article-title: N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity publication-title: Kidney Int. – volume: 107 start-page: 499 year: 2003 end-page: 511 ident: bib33 article-title: Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association publication-title: Circulation – volume: 14 start-page: S1 year: 2007 end-page: 113 ident: bib1 article-title: European guidelines on cardiovascular disease prevention in clinical practice: full text Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts) publication-title: Eur. J. Cardiovasc. Prev. Rehabil. – volume: 284 start-page: 15400 year: 2009 end-page: 15407 ident: bib6 article-title: Effect of dietary fatty acids on inflammatory gene expression in healthy humans publication-title: J. Biol. Chem. – volume: 56 start-page: 59 year: 2010 end-page: 82 ident: bib20 article-title: Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils publication-title: Cell. Mol. Biol. (Noisy-le-grand) – volume: 34 start-page: 317 year: 1999 end-page: 324 ident: bib8 article-title: Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men publication-title: Lipids – volume: 27 start-page: 217 year: 1984 end-page: 232 ident: bib23 article-title: Biosynthesis and biological activity of leukotriene B5 publication-title: Prostaglandins – volume: 18 start-page: 51 year: 2001 end-page: 58 ident: bib10 article-title: n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro-inflammatory mediators in Type 2 diabetes mellitus publication-title: Diabet. Med. – volume: 1 start-page: 215 year: 1985 end-page: 225 ident: bib17 article-title: Gas chromatography–mass spectrometry method for determination of phospholipid peroxides, I: transesterification to form methyl esters publication-title: J. Free Radic. Biol. Med. – volume: 83 start-page: 456S year: 2006 end-page: 460S ident: bib3 article-title: Inflammation and cardiovascular disease mechanisms publication-title: Am. J. Clin. Nutr. – volume: 178 start-page: 3912 year: 2007 end-page: 3917 ident: bib34 article-title: Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation publication-title: J. Immunol. – volume: 8 start-page: S4 year: 2007 end-page: 10 ident: bib21 article-title: Incorporation and washout of n-3 polyunsaturated fatty acids after diet supplementation in clinical studies publication-title: J. Cardiovasc. Med. (Hagerstown) – volume: 331 start-page: 1111 year: 2009 end-page: 1117 ident: bib22 article-title: Differential effects of arachidonic and eicosapentaenoic acid-derived eicosanoids on polymorphonuclear transmigration across endothelial cell cultures publication-title: J. Pharmacol. Exp. Ther. – volume: 8 start-page: S4 issue: Suppl. 1 year: 2007 ident: 10.1016/j.plefa.2012.05.009_bib21 article-title: Incorporation and washout of n-3 polyunsaturated fatty acids after diet supplementation in clinical studies publication-title: J. Cardiovasc. Med. (Hagerstown) doi: 10.2459/01.JCM.0000289269.98105.65 – volume: 28 start-page: 71 year: 2009 ident: 10.1016/j.plefa.2012.05.009_bib24 article-title: Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells publication-title: Clin. Nutr. doi: 10.1016/j.clnu.2008.10.012 – volume: 18 start-page: 51 year: 2001 ident: 10.1016/j.plefa.2012.05.009_bib10 article-title: n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro-inflammatory mediators in Type 2 diabetes mellitus publication-title: Diabet. Med. doi: 10.1046/j.1464-5491.2001.00410.x – volume: 134 start-page: 671 year: 1989 ident: 10.1016/j.plefa.2012.05.009_bib27 article-title: In vivo chemotaxis of bovine neutrophils induced by 5-lipoxygenase metabolites of arachidonic and eicosapentaenoic acid publication-title: Am. J. Pathol. – volume: 74 start-page: 1922 year: 1984 ident: 10.1016/j.plefa.2012.05.009_bib30 article-title: Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils publication-title: J. Clin. Invest. doi: 10.1172/JCI111612 – volume: 14 start-page: S1 issue: Suppl. 2 year: 2007 ident: 10.1016/j.plefa.2012.05.009_bib1 publication-title: Eur. J. Cardiovasc. Prev. Rehabil. doi: 10.1097/01.hjr.0000277983.23934.c9 – year: 1987 ident: 10.1016/j.plefa.2012.05.009_bib18 – volume: 34 start-page: S185 issue: Suppl. year: 1999 ident: 10.1016/j.plefa.2012.05.009_bib9 article-title: The effect of n-3 fatty acids on leukotriene formation from neutrophils in patients on hemodialysis publication-title: Lipids doi: 10.1007/BF02562283 – volume: 268 start-page: 9280 year: 1993 ident: 10.1016/j.plefa.2012.05.009_bib28 article-title: Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)98347-X – volume: 34 start-page: 317 year: 1999 ident: 10.1016/j.plefa.2012.05.009_bib8 article-title: Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men publication-title: Lipids doi: 10.1007/s11745-999-0369-5 – volume: 277 start-page: 31459 year: 2002 ident: 10.1016/j.plefa.2012.05.009_bib29 article-title: Identification of a novel human eicosanoid receptor coupled to G(i/o) publication-title: J. Biol. Chem. doi: 10.1074/jbc.M203194200 – volume: 284 start-page: 15400 year: 2009 ident: 10.1016/j.plefa.2012.05.009_bib6 article-title: Effect of dietary fatty acids on inflammatory gene expression in healthy humans publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.004861 – volume: 100 start-page: 829 year: 2008 ident: 10.1016/j.plefa.2012.05.009_bib7 article-title: Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers publication-title: Br. J. Nutr. doi: 10.1017/S0007114508923692 – volume: 32 start-page: 15 year: 2012 ident: 10.1016/j.plefa.2012.05.009_bib14 article-title: Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects publication-title: Nutr. Res. doi: 10.1016/j.nutres.2011.12.007 – ident: 10.1016/j.plefa.2012.05.009_bib15 – volume: 23 start-page: 151 year: 2003 ident: 10.1016/j.plefa.2012.05.009_bib2 article-title: Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/01.ATV.0000057393.97337.AE – volume: 83 start-page: 456S year: 2006 ident: 10.1016/j.plefa.2012.05.009_bib3 article-title: Inflammation and cardiovascular disease mechanisms publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/83.2.456S – volume: 311 start-page: 158 year: 1995 ident: 10.1016/j.plefa.2012.05.009_bib16 article-title: Waist circumference as a measure for indicating need for weight management publication-title: Br. Med. J. doi: 10.1136/bmj.311.6998.158 – volume: 27 start-page: 217 year: 1984 ident: 10.1016/j.plefa.2012.05.009_bib23 article-title: Biosynthesis and biological activity of leukotriene B5 publication-title: Prostaglandins doi: 10.1016/0090-6980(84)90075-3 – volume: 312 start-page: 1217 year: 1985 ident: 10.1016/j.plefa.2012.05.009_bib12 article-title: Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198505093121903 – volume: 1 start-page: 215 year: 1985 ident: 10.1016/j.plefa.2012.05.009_bib17 article-title: Gas chromatography–mass spectrometry method for determination of phospholipid peroxides, I: transesterification to form methyl esters publication-title: J. Free Radic. Biol. Med. doi: 10.1016/0748-5514(85)90121-7 – volume: 14 start-page: 347 year: 2011 ident: 10.1016/j.plefa.2012.05.009_bib5 article-title: The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/MCO.0b013e32834777fa – volume: 36 start-page: 2590 year: 1995 ident: 10.1016/j.plefa.2012.05.009_bib31 article-title: Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)41095-8 – volume: 129 start-page: 39 year: 2006 ident: 10.1016/j.plefa.2012.05.009_bib13 article-title: Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma publication-title: Chest doi: 10.1378/chest.129.1.39 – volume: 56 start-page: 59 year: 2010 ident: 10.1016/j.plefa.2012.05.009_bib20 article-title: Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils publication-title: Cell. Mol. Biol. (Noisy-le-grand) – volume: 107 start-page: 499 year: 2003 ident: 10.1016/j.plefa.2012.05.009_bib33 article-title: Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association publication-title: Circulation doi: 10.1161/01.CIR.0000052939.59093.45 – volume: 41 start-page: 30 year: 2011 ident: 10.1016/j.plefa.2012.05.009_bib32 article-title: Body mass index is associated with leukotriene inflammation in asthmatics publication-title: Eur. J. Clin. Invest. doi: 10.1111/j.1365-2362.2010.02371.x – volume: 69 start-page: 1450 year: 2006 ident: 10.1016/j.plefa.2012.05.009_bib25 article-title: N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity publication-title: Kidney Int. doi: 10.1038/sj.ki.5000291 – volume: 331 start-page: 1111 year: 2009 ident: 10.1016/j.plefa.2012.05.009_bib22 article-title: Differential effects of arachidonic and eicosapentaenoic acid-derived eicosanoids on polymorphonuclear transmigration across endothelial cell cultures publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.109.157891 – volume: 23 start-page: 41 year: 2009 ident: 10.1016/j.plefa.2012.05.009_bib4 article-title: Leukotriene signaling in atherosclerosis and ischemia publication-title: Cardiovasc. Drugs Ther. doi: 10.1007/s10557-008-6140-9 – volume: 66 start-page: 391 year: 1991 ident: 10.1016/j.plefa.2012.05.009_bib19 article-title: Effects of dietary fish oil on leukocyte leukotriene and PAF generation and on neutrophil chemotaxis publication-title: World Rev. Nutr. Diet. doi: 10.1159/000419307 – volume: 178 start-page: 3912 year: 2007 ident: 10.1016/j.plefa.2012.05.009_bib34 article-title: Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation publication-title: J. Immunol. doi: 10.4049/jimmunol.178.6.3912 – volume: 6 start-page: 402 year: 1986 ident: 10.1016/j.plefa.2012.05.009_bib11 article-title: Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid publication-title: J. Clin. Immunol. doi: 10.1007/BF00915380 – volume: 85 start-page: 37 year: 2011 ident: 10.1016/j.plefa.2012.05.009_bib26 article-title: The effect of n-3 polyunsaturated fatty acids on leukotriene B(4) and leukotriene B(5) production from stimulated neutrophil granulocytes in patients with chronic kidney disease publication-title: Prostaglandins Leukot. Essent. Fatty Acids doi: 10.1016/j.plefa.2011.04.004 |
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| Snippet | Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but... Abstract Introduction Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA... |
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| SubjectTerms | 5-Lipoxygenase Advanced Basic Science Aged Anti-Inflammatory Agents - administration & dosage Arachidonate 5-Lipoxygenase - metabolism Cardiotonic Agents - administration & dosage Cell Membrane - metabolism Double-Blind Method Eicosapentaenoic Acid - analogs & derivatives Eicosapentaenoic Acid - biosynthesis Endocrinology & Metabolism Fatty Acids, Omega-3 - administration & dosage Female Humans Hydroxyeicosatetraenoic Acids - biosynthesis Leukotriene B4 - analogs & derivatives Leukotriene B4 - biosynthesis Leukotrienes Male Marine n-3 polyunsaturated fatty acids Middle Aged Multivariate Analysis Neutrophils - metabolism Obesity, Abdominal - drug therapy Obesity, Abdominal - pathology Overweight - drug therapy Overweight - pathology Treatment Outcome |
| Title | The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: A randomized controlled trial |
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