The Role of HIF in Immunity and Inflammation
HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization ca...
Saved in:
| Published in | Cell metabolism Vol. 32; no. 4; pp. 524 - 536 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
06.10.2020
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors.
The transcription factor HIF has emerged as a key regulator of immune cell function during both hypoxia and normoxia. In this article, McGettrick and O’Neill review the role of HIF in different immune cells and discuss the role of HIF in multiple inflammatory diseases and in immunosuppression in tumors. |
|---|---|
| AbstractList | HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors.HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors. HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors. HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-α stabilization can also occur under normoxia during immunity and inflammation, where it regulates metabolism but in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role in macrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors. The transcription factor HIF has emerged as a key regulator of immune cell function during both hypoxia and normoxia. In this article, McGettrick and O’Neill review the role of HIF in different immune cells and discuss the role of HIF in multiple inflammatory diseases and in immunosuppression in tumors. |
| Author | O’Neill, Luke A.J. McGettrick, Anne F. |
| Author_xml | – sequence: 1 givenname: Anne F. surname: McGettrick fullname: McGettrick, Anne F. email: mcgettra@tcd.ie organization: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland – sequence: 2 givenname: Luke A.J. surname: O’Neill fullname: O’Neill, Luke A.J. organization: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32853548$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kE1LxDAQQIOs6Lr6BzxIjx5snXw0TcGLiKsFQRA9hzSdYpY21aQr7L-366oHD55mDu8NzDsiMz94JOSUQkaBystVZnscMwYMMlAZANsjc1pylhaCwWza8xxSQTk9JEcxrgC45CU_IIecqZznQs3JxfMrJk9Dh8nQJvfVMnE-qfp-7d24SYxvksq3nel7M7rBH5P91nQRT77ngrwsb59v7tOHx7vq5vohtULKMc3ruhANFJA3ijJlEcsSmWxz3khri7owquDABQWU1LQChVV1UbYWqbFUAF-Q893dtzC8rzGOunfRYtcZj8M6aia4koXMSz6hZ9_ouu6x0W_B9SZs9M-HE8B2gA1DjAHbX4SC3mbUK73NqLcZNSg9ZZwk9UeybvxKMAbjuv_Vq52KU6APh0FH69BbbFxAO-pmcP_pn-agitg |
| CitedBy_id | crossref_primary_10_1016_j_critrevonc_2021_103227 crossref_primary_10_1007_s00239_024_10155_2 crossref_primary_10_2174_1871530322666220921160930 crossref_primary_10_3390_ijms242317032 crossref_primary_10_1016_j_cell_2023_11_032 crossref_primary_10_1097_JCMA_0000000000000921 crossref_primary_10_1172_JCI148548 crossref_primary_10_7717_peerj_15591 crossref_primary_10_1016_j_neurobiolaging_2021_07_017 crossref_primary_10_3390_ijms23042139 crossref_primary_10_3390_cells11030391 crossref_primary_10_1080_19490976_2023_2263936 crossref_primary_10_1016_j_cellimm_2024_104861 crossref_primary_10_1016_j_jtcme_2023_05_002 crossref_primary_10_1007_s00438_024_02144_3 crossref_primary_10_3390_ijms241914839 crossref_primary_10_3389_fendo_2023_1089796 crossref_primary_10_1126_scisignal_add2282 crossref_primary_10_3389_fncel_2022_955511 crossref_primary_10_3748_wjg_v28_i38_5573 crossref_primary_10_3390_cancers15041324 crossref_primary_10_1016_j_neubiorev_2022_104718 crossref_primary_10_3389_fimmu_2021_814278 crossref_primary_10_1038_s12276_024_01175_5 crossref_primary_10_1167_iovs_63_11_7 crossref_primary_10_1016_j_bioorg_2022_106173 crossref_primary_10_1177_17588359221138383 crossref_primary_10_1016_j_ejphar_2023_176277 crossref_primary_10_1111_nep_14064 crossref_primary_10_3390_biom14121592 crossref_primary_10_1016_j_abb_2023_109822 crossref_primary_10_1016_j_ydbio_2022_02_004 crossref_primary_10_34067_KID_0000000000000437 crossref_primary_10_1016_j_jbc_2024_107606 crossref_primary_10_3390_cimb45020114 crossref_primary_10_1016_j_xcrm_2024_101790 crossref_primary_10_3389_fimmu_2022_934819 crossref_primary_10_3389_fvets_2024_1463160 crossref_primary_10_1038_s41392_024_02095_6 crossref_primary_10_3390_metabo11110736 crossref_primary_10_3389_fimmu_2022_928379 crossref_primary_10_1038_s41392_022_01080_1 crossref_primary_10_1016_j_bbrc_2024_149920 crossref_primary_10_3390_cells13100844 crossref_primary_10_1093_ndt_gfae273 crossref_primary_10_3390_pharmaceutics13091338 crossref_primary_10_1016_j_preteyeres_2021_100940 crossref_primary_10_1016_j_ecoenv_2023_114773 crossref_primary_10_1016_j_intimp_2024_113892 crossref_primary_10_23876_j_krcp_23_012 crossref_primary_10_1021_acsnano_3c12387 crossref_primary_10_3389_fmicb_2022_1037469 crossref_primary_10_1038_s41392_023_01496_3 crossref_primary_10_1161_ATVBAHA_123_320367 crossref_primary_10_1155_2021_6015702 crossref_primary_10_3389_fmolb_2022_1025690 crossref_primary_10_3892_or_2024_8714 crossref_primary_10_1515_teb_2024_0037 crossref_primary_10_1038_s41419_022_04711_1 crossref_primary_10_17826_cumj_1174607 crossref_primary_10_3389_fphar_2024_1382256 crossref_primary_10_4081_mrm_2023_927 crossref_primary_10_1080_14728222_2023_2248381 crossref_primary_10_3390_antiox13070878 crossref_primary_10_1186_s10020_025_01144_2 crossref_primary_10_3390_pharmaceutics16111375 crossref_primary_10_1080_21505594_2022_2035066 crossref_primary_10_1096_fj_202400283R crossref_primary_10_3390_separations11060184 crossref_primary_10_1038_s41598_024_56958_7 crossref_primary_10_3389_fnmol_2023_1123955 crossref_primary_10_1038_s41401_024_01389_3 crossref_primary_10_3390_biom14030330 crossref_primary_10_1016_j_matdes_2024_112844 crossref_primary_10_1016_j_ebiom_2022_103942 crossref_primary_10_1016_j_jconrel_2022_09_020 crossref_primary_10_1371_journal_pbio_3002690 crossref_primary_10_1016_j_celrep_2023_111991 crossref_primary_10_4049_jimmunol_2300293 crossref_primary_10_1016_j_mattod_2023_07_003 crossref_primary_10_7717_peerj_15009 crossref_primary_10_1186_s40164_023_00394_2 crossref_primary_10_1016_j_intimp_2023_110054 crossref_primary_10_3390_jcm12134205 crossref_primary_10_1093_cei_uxac025 crossref_primary_10_1038_s41575_022_00658_y crossref_primary_10_1038_s41467_024_53006_w crossref_primary_10_3390_molecules28020814 crossref_primary_10_3390_molecules26010005 crossref_primary_10_1161_ATVBAHA_121_317257 crossref_primary_10_1007_s00018_024_05289_x crossref_primary_10_1016_S0140_6736_24_00495_1 crossref_primary_10_1007_s10126_022_10158_4 crossref_primary_10_1002_mco2_181 crossref_primary_10_2174_1568009622666220428111327 crossref_primary_10_1097_MOH_0000000000000645 crossref_primary_10_1016_j_carbpol_2024_122960 crossref_primary_10_1183_16000617_0173_2022 crossref_primary_10_1089_ham_2024_0006 crossref_primary_10_7717_peerj_15191 crossref_primary_10_1016_j_molmed_2022_09_004 crossref_primary_10_1016_j_intimp_2022_108543 crossref_primary_10_3389_fgene_2022_909095 crossref_primary_10_1038_s41598_022_12751_y crossref_primary_10_1136_jitc_2024_009602 crossref_primary_10_1007_s11356_024_32030_9 crossref_primary_10_1093_infdis_jiad339 crossref_primary_10_1016_j_jshs_2023_09_007 crossref_primary_10_1007_s11033_024_09772_3 crossref_primary_10_1038_s41423_022_00962_2 crossref_primary_10_1016_j_jare_2024_04_004 crossref_primary_10_1016_j_ymthe_2021_03_022 crossref_primary_10_3390_md20110660 crossref_primary_10_1155_2021_9958281 crossref_primary_10_3389_fimmu_2023_1291530 crossref_primary_10_1016_j_fsi_2023_109222 crossref_primary_10_1186_s10020_025_01155_z crossref_primary_10_1016_j_phrs_2024_107537 crossref_primary_10_1016_j_ecoenv_2024_116534 crossref_primary_10_1007_s00467_023_06031_8 crossref_primary_10_1016_j_jep_2025_119453 crossref_primary_10_1248_bpbreports_6_5_155 crossref_primary_10_3390_cancers13020180 crossref_primary_10_1016_j_freeradbiomed_2023_11_003 crossref_primary_10_3389_fimmu_2023_1216094 crossref_primary_10_3390_molecules28207037 crossref_primary_10_1016_j_arr_2024_102551 crossref_primary_10_15789_1563_0625_PAO_2779 crossref_primary_10_3389_fbioe_2023_1264006 crossref_primary_10_1016_j_etap_2022_104024 crossref_primary_10_1007_s11684_024_1090_6 crossref_primary_10_2139_ssrn_4066283 crossref_primary_10_1186_s12964_021_00742_x crossref_primary_10_3389_fgene_2022_959456 crossref_primary_10_7554_eLife_89319 crossref_primary_10_1002_advs_202200841 crossref_primary_10_1016_j_freeradbiomed_2025_01_054 crossref_primary_10_1249_MSS_0000000000003483 crossref_primary_10_1007_s10787_024_01609_6 crossref_primary_10_3390_antibiotics12040731 crossref_primary_10_1155_2022_7232457 crossref_primary_10_3389_fphar_2021_729334 crossref_primary_10_1128_jvi_01038_24 crossref_primary_10_1016_j_copbio_2023_102996 crossref_primary_10_1016_j_ymthe_2022_12_014 crossref_primary_10_1097_SHK_0000000000001694 crossref_primary_10_1186_s12951_024_02663_6 crossref_primary_10_1016_j_intimp_2024_113494 crossref_primary_10_3390_cells10102595 crossref_primary_10_1186_s40104_021_00587_x crossref_primary_10_3389_fonc_2024_1370393 crossref_primary_10_1016_j_biomaterials_2024_122884 crossref_primary_10_1016_j_jss_2022_07_041 crossref_primary_10_3389_fimmu_2022_840029 crossref_primary_10_1016_j_actbio_2023_01_058 crossref_primary_10_1007_s43440_023_00497_x crossref_primary_10_1002_jcp_31384 crossref_primary_10_1186_s13287_024_04028_0 crossref_primary_10_7554_eLife_80881 crossref_primary_10_1089_ars_2019_7901 crossref_primary_10_1016_j_fsi_2024_109962 crossref_primary_10_3389_fmolb_2021_752465 crossref_primary_10_3389_fimmu_2021_801985 crossref_primary_10_3390_ijms26051839 crossref_primary_10_3389_fimmu_2023_1198972 crossref_primary_10_1016_j_isci_2024_110751 crossref_primary_10_1016_j_brainresbull_2022_06_016 crossref_primary_10_1038_s41581_022_00587_8 crossref_primary_10_3390_antiox12112016 crossref_primary_10_1016_j_jconrel_2025_02_005 crossref_primary_10_3390_antiox13111378 crossref_primary_10_1016_j_devcel_2023_07_006 crossref_primary_10_46235_1028_7221_16818_TMC crossref_primary_10_4143_crt_2024_255 crossref_primary_10_2147_JIR_S484914 crossref_primary_10_1016_j_bbrc_2024_151104 crossref_primary_10_1016_j_jnutbio_2023_109510 crossref_primary_10_1016_j_nantod_2022_101565 crossref_primary_10_1186_s12974_024_03070_2 crossref_primary_10_1016_j_it_2023_08_008 crossref_primary_10_1172_JCI136459 crossref_primary_10_3390_cells13050397 crossref_primary_10_1016_j_exger_2020_111147 crossref_primary_10_1016_j_semcdb_2022_04_002 crossref_primary_10_1016_j_jconrel_2025_02_010 crossref_primary_10_1016_j_actbio_2024_01_010 crossref_primary_10_3389_fimmu_2025_1514061 crossref_primary_10_1002_tox_23476 crossref_primary_10_1016_j_bbamcr_2023_119625 crossref_primary_10_1186_s12951_024_02565_7 crossref_primary_10_7717_peerj_16052 crossref_primary_10_1183_13993003_00787_2023 crossref_primary_10_1038_s41556_023_01149_1 crossref_primary_10_1126_sciadv_abo7555 crossref_primary_10_3389_fimmu_2024_1365718 crossref_primary_10_1134_S002209302403027X crossref_primary_10_3389_fimmu_2022_910022 crossref_primary_10_1038_s41419_024_06696_5 crossref_primary_10_1016_j_celrep_2024_114727 crossref_primary_10_3390_life15030451 crossref_primary_10_1113_JP284588 crossref_primary_10_3390_ijms25189933 crossref_primary_10_1161_CIRCRESAHA_123_324086 crossref_primary_10_1128_mBio_02710_21 crossref_primary_10_1016_j_bioflm_2025_100264 crossref_primary_10_1021_jacs_3c03031 crossref_primary_10_3390_ph16030451 crossref_primary_10_1002_agt2_587 crossref_primary_10_3390_ani12213036 crossref_primary_10_1007_s00011_023_01842_9 crossref_primary_10_3389_fimmu_2023_1213629 crossref_primary_10_1007_s10571_022_01293_6 crossref_primary_10_1111_all_16394 crossref_primary_10_1186_s43046_023_00186_z crossref_primary_10_3389_fcell_2022_818082 crossref_primary_10_1111_febs_16928 crossref_primary_10_1007_s00441_023_03850_x crossref_primary_10_7717_peerj_19024 crossref_primary_10_1113_JP284599 crossref_primary_10_1002_adma_202501051 crossref_primary_10_3390_microorganisms11020461 crossref_primary_10_1186_s12964_023_01450_4 crossref_primary_10_1016_j_celrep_2023_112131 crossref_primary_10_1166_jbn_2024_3873 crossref_primary_10_1007_s12035_022_03057_1 crossref_primary_10_3390_cells11192938 crossref_primary_10_3390_ijms23116155 crossref_primary_10_1016_j_isci_2023_107985 crossref_primary_10_1016_j_neuroscience_2024_06_021 crossref_primary_10_3390_ijms252413451 crossref_primary_10_3390_jcm12154987 crossref_primary_10_3389_fphar_2024_1344755 crossref_primary_10_1172_JCI174051 crossref_primary_10_3390_biomedicines13030729 crossref_primary_10_1038_s41467_024_52113_y crossref_primary_10_1136_bmjonc_2023_000154 crossref_primary_10_1016_j_jconrel_2025_02_053 crossref_primary_10_1016_j_jconrel_2025_02_054 crossref_primary_10_1016_j_tem_2023_11_002 crossref_primary_10_3390_ijms25169085 crossref_primary_10_1038_s44318_024_00039_y crossref_primary_10_7554_eLife_89319_4 crossref_primary_10_3389_fphys_2022_909569 crossref_primary_10_1016_j_gendis_2021_08_004 crossref_primary_10_1016_j_bbamcr_2024_119683 crossref_primary_10_3389_fimmu_2023_1211221 crossref_primary_10_1016_j_bbagen_2023_130548 crossref_primary_10_1002_smll_202305728 crossref_primary_10_3389_fimmu_2023_1327852 crossref_primary_10_1177_0271678X221098841 crossref_primary_10_1080_14656566_2021_1993821 crossref_primary_10_3390_biomedicines11082163 crossref_primary_10_4049_jimmunol_2400123 crossref_primary_10_1186_s12882_024_03474_5 crossref_primary_10_3389_fphar_2024_1346719 crossref_primary_10_3390_ijms23084138 crossref_primary_10_1038_s41418_025_01466_y crossref_primary_10_3390_ijms25010255 crossref_primary_10_1016_j_dci_2024_105292 crossref_primary_10_1186_s12951_022_01752_8 crossref_primary_10_1126_sciadv_adq5226 crossref_primary_10_3390_v15020525 crossref_primary_10_1039_D4FO04019H crossref_primary_10_1111_imr_13199 crossref_primary_10_1093_femspd_ftac047 crossref_primary_10_7554_eLife_70555 crossref_primary_10_1097_MD_0000000000036144 crossref_primary_10_1021_acscentsci_4c02156 crossref_primary_10_1016_j_jep_2023_116533 crossref_primary_10_1080_10715762_2024_2407147 crossref_primary_10_1186_s13045_022_01292_6 crossref_primary_10_1016_j_exer_2022_108984 crossref_primary_10_1038_s41467_024_47814_3 crossref_primary_10_1038_s41573_023_00848_6 crossref_primary_10_1016_j_bioadv_2024_213937 crossref_primary_10_1016_j_ijpharm_2022_122370 crossref_primary_10_3389_fimmu_2022_843369 crossref_primary_10_1016_j_tcb_2022_08_005 crossref_primary_10_3390_antiox10010048 crossref_primary_10_1186_s13046_023_02832_9 crossref_primary_10_3389_fonc_2021_786089 crossref_primary_10_3390_biomedicines13010150 crossref_primary_10_1038_s41467_024_51882_w crossref_primary_10_1016_j_phymed_2024_156089 crossref_primary_10_1016_j_chom_2024_11_012 crossref_primary_10_3390_cells12121584 crossref_primary_10_1080_15476286_2024_2408706 crossref_primary_10_1021_acs_jmedchem_3c02227 crossref_primary_10_1016_j_ccell_2024_08_007 crossref_primary_10_1038_s41564_024_01882_9 crossref_primary_10_3389_fimmu_2023_1224102 crossref_primary_10_1016_j_isci_2021_103607 crossref_primary_10_3389_fimmu_2025_1515430 crossref_primary_10_1038_s41589_022_01169_2 crossref_primary_10_1016_j_cmet_2021_12_019 crossref_primary_10_1016_j_bbadis_2025_167706 crossref_primary_10_1073_pnas_2309957121 crossref_primary_10_1016_j_heliyon_2024_e37792 crossref_primary_10_1186_s12964_023_01323_w crossref_primary_10_12677_ACM_2021_1111763 crossref_primary_10_1016_j_intimp_2022_109193 crossref_primary_10_3390_jpm12101646 crossref_primary_10_1186_s12951_023_01949_5 crossref_primary_10_1152_ajpendo_00483_2020 crossref_primary_10_3389_fimmu_2023_1271118 crossref_primary_10_1016_j_apmt_2022_101677 crossref_primary_10_3390_molecules27217318 crossref_primary_10_1007_s13668_023_00452_5 crossref_primary_10_1016_j_cyto_2022_156107 crossref_primary_10_1038_s41423_021_00726_4 crossref_primary_10_1038_s41571_021_00539_4 crossref_primary_10_1016_j_biopha_2023_114770 crossref_primary_10_3389_fphys_2025_1507059 crossref_primary_10_3390_ijms24021367 crossref_primary_10_1038_s41598_024_57948_5 crossref_primary_10_1002_anbr_202300061 crossref_primary_10_1016_j_bone_2024_117132 crossref_primary_10_3389_fnagi_2021_653334 crossref_primary_10_1016_j_biocel_2022_106312 crossref_primary_10_1016_j_cej_2022_139839 crossref_primary_10_1002_iid3_1268 crossref_primary_10_1007_s10753_025_02239_y crossref_primary_10_1002_mds_28544 crossref_primary_10_3390_medicina59122170 crossref_primary_10_1002_ctm2_70136 crossref_primary_10_1080_16078454_2023_2240138 crossref_primary_10_1016_j_phymed_2022_154469 crossref_primary_10_1016_j_jceh_2024_101365 crossref_primary_10_33549_physiolres_935436 crossref_primary_10_1016_j_freeradbiomed_2024_02_002 crossref_primary_10_3389_ti_2024_12822 crossref_primary_10_3390_ijms25115896 crossref_primary_10_1016_j_bbih_2024_100928 crossref_primary_10_1002_ptr_7953 crossref_primary_10_1016_j_omtn_2023_102036 crossref_primary_10_1126_sciimmunol_adg3517 crossref_primary_10_3390_immuno1020006 crossref_primary_10_1016_j_heliyon_2023_e15224 crossref_primary_10_20900_immunometab20210021 crossref_primary_10_1038_s41392_024_02076_9 crossref_primary_10_1007_s12011_025_04519_y crossref_primary_10_1093_rb_rbad026 crossref_primary_10_1038_s41467_025_57819_1 crossref_primary_10_1016_j_nantod_2024_102519 crossref_primary_10_3390_ijms23105658 crossref_primary_10_1016_j_brainresbull_2023_02_002 crossref_primary_10_2139_ssrn_4012188 crossref_primary_10_1016_j_gendis_2024_101240 crossref_primary_10_3389_fimmu_2024_1385907 crossref_primary_10_1007_s10695_023_01233_1 crossref_primary_10_1096_fj_202200329RR crossref_primary_10_3390_cancers14246054 crossref_primary_10_3390_ijms24010558 crossref_primary_10_1016_j_pbiomolbio_2023_09_002 crossref_primary_10_1007_s12672_023_00758_4 crossref_primary_10_3892_etm_2024_12722 crossref_primary_10_1002_advs_202406060 crossref_primary_10_1155_2021_9987383 crossref_primary_10_31857_S0869813924060099 crossref_primary_10_3389_fmicb_2024_1457348 crossref_primary_10_1038_s42255_024_01092_x crossref_primary_10_3389_fonc_2022_984525 crossref_primary_10_1016_j_intimp_2024_112957 crossref_primary_10_1016_j_micpath_2024_106889 crossref_primary_10_1016_j_jss_2024_06_016 crossref_primary_10_1016_j_isci_2024_110285 crossref_primary_10_3390_antiox11050861 crossref_primary_10_1002_adfm_202101040 crossref_primary_10_1111_all_15384 crossref_primary_10_1016_j_dci_2022_104598 crossref_primary_10_3389_fonc_2022_1096717 crossref_primary_10_3899_jrheum_2023_0654 crossref_primary_10_1007_s00262_023_03563_8 crossref_primary_10_1016_j_biosystems_2024_105257 crossref_primary_10_1002_mco2_418 crossref_primary_10_3389_fonc_2022_992260 crossref_primary_10_3389_fimmu_2021_719009 crossref_primary_10_1093_jleuko_qiae126 crossref_primary_10_1152_ajplung_00065_2022 crossref_primary_10_1016_j_jmb_2023_168332 crossref_primary_10_3389_fimmu_2020_621750 crossref_primary_10_1016_j_jbc_2025_108296 crossref_primary_10_3389_fonc_2023_1268190 crossref_primary_10_3389_fmed_2024_1460376 crossref_primary_10_3390_cancers16132483 crossref_primary_10_1002_1873_3468_15001 crossref_primary_10_1016_j_bbrc_2024_149613 crossref_primary_10_3389_fimmu_2023_1168799 crossref_primary_10_1038_s41568_021_00375_9 crossref_primary_10_1097_MD_0000000000039350 crossref_primary_10_1186_s12979_023_00403_2 crossref_primary_10_1016_j_bioactmat_2023_10_017 crossref_primary_10_1093_ibd_izae046 crossref_primary_10_1152_ajpcell_00227_2022 crossref_primary_10_1002_cbic_202400854 crossref_primary_10_1016_j_vaccine_2023_12_010 crossref_primary_10_7554_eLife_75873 crossref_primary_10_1186_s13045_022_01358_5 crossref_primary_10_1155_2022_4247042 crossref_primary_10_1182_blood_2022015674 crossref_primary_10_3390_ijms25031560 crossref_primary_10_1093_mmy_myac011 crossref_primary_10_1038_s41467_023_42634_3 crossref_primary_10_3390_cells11091381 |
| Cites_doi | 10.4049/jimmunol.1601080 10.4161/15548627.2014.984275 10.1016/j.ccell.2017.10.003 10.1186/ar1447 10.1016/j.cell.2012.01.021 10.1016/0140-6736(91)91133-F 10.1038/nm1468 10.1016/j.molimm.2009.09.038 10.1016/j.celrep.2020.02.098 10.1016/j.cell.2016.07.032 10.1155/2014/928461 10.4049/jimmunol.0800167 10.4049/jimmunol.1601401 10.3389/fphar.2016.00184 10.1371/journal.ppat.1006874 10.1126/science.1250684 10.1002/hep.28001 10.1016/j.cell.2016.08.064 10.1016/S0092-8674(03)00154-5 10.1182/blood-2008-02-142091 10.1182/blood.V89.2.503 10.1074/jbc.M305101200 10.1038/s41467-019-10626-x 10.1016/j.ccr.2004.11.022 10.1016/j.immuni.2015.02.001 10.1038/nature11986 10.1038/ncomms3813 10.1038/nm.3931 10.1371/journal.pone.0072650 10.1097/SHK.0b013e318225ad7e 10.1086/524843 10.1189/jlb.0208082 10.1097/ALN.0b013e31828baa67 10.1182/blood-2013-05-500207 10.1371/journal.pone.0038489 10.1084/jem.20110278 10.1038/s41598-018-21891-z 10.1002/eji.201545784 10.1371/journal.pone.0011576 10.1111/jphp.12655 10.4049/jimmunol.1501612 10.1038/s41467-018-04804-6 10.1038/ni1488 10.1074/jbc.270.3.1230 10.1042/BSR20160031 10.1016/j.cmet.2015.01.017 10.1084/jem.178.6.2249 10.1038/35017054 10.1016/j.molimm.2007.12.002 10.1126/science.1092385 10.1016/j.jaci.2019.10.008 10.1186/s12943-017-0665-0 10.1182/blood-2012-01-405993 10.1084/jem.20131916 10.1002/jcp.22761 10.1002/eji.200526262 10.1073/pnas.92.12.5510 10.1158/0008-5472.CAN-08-4603 10.1016/j.cellimm.2018.10.007 10.1073/pnas.1811702116 10.4049/jimmunol.179.7.4313 10.4049/jimmunol.178.12.7516 10.4049/jimmunol.1402552 10.1002/jcp.24666 10.1016/j.omtn.2020.01.014 10.1038/mi.2013.29 10.1084/jem.20062292 10.1042/BSR20182019 10.3181/00379727-173-41646 10.1073/pnas.1420419112 10.1371/journal.pone.0068376 10.1002/ijc.10261 10.1002/eji.200838318 10.1136/jcp.56.3.209 10.1016/j.jaut.2018.07.022 10.1016/S1471-4914(02)02317-1 10.1136/annrheumdis-2015-208476 10.1084/jem.160.6.1656 10.4049/jimmunol.180.7.4697 10.1126/scisignal.2000431 10.1093/intimm/dxs098 10.1371/journal.pone.0000853 10.1093/neuros/nyx149 10.1093/jnci/93.4.266 10.1084/jem.20040624 10.1042/bj3500307 10.1042/BJ20051839 10.1172/JCI39506 10.1038/379088a0 10.1038/20459 10.3389/fimmu.2016.00518 10.1007/s10456-015-9477-2 10.1016/j.immuni.2014.09.008 10.1155/2012/849136 10.4161/gmic.18771 10.5001/omj.2020.08 10.1073/pnas.1202366109 10.1097/SHK.0b013e318231866f 10.1172/JCI200421086 10.1101/gad.1881410 10.1016/j.semcancer.2005.04.009 10.2217/fmb-2017-0168 10.1038/nature19334 10.3181/00379727-94-22910 10.1172/JCI23865 10.1038/nrrheum.2011.205 10.1038/mi.2015.67 10.1155/2013/710239 10.1126/science.aaf6284 10.1182/blood-2002-02-0454 10.1002/eji.201142053 10.1182/blood-2006-04-018796 10.1002/art.1780130606 10.4049/jimmunol.1003613 10.1182/blood-2013-04-457671 10.1016/j.imbio.2008.07.031 10.1016/j.immuni.2015.05.016 10.1111/myc.12498 10.1016/S0304-3835(03)00012-0 10.1073/pnas.1520032112 10.1074/jbc.M809266200 10.1182/blood-2007-11-126763 10.4049/jimmunol.1401420 10.1136/gut.40.3.320 10.1053/j.gastro.2007.10.012 10.1007/s10555-007-9055-1 10.3390/molecules22010134 10.1016/j.cell.2011.03.054 10.1016/j.imlet.2007.09.009 10.1038/ni.2714 10.1158/0008-5472.CAN-11-2104 10.1038/nature06734 10.1016/j.molimm.2019.04.005 10.1016/j.cell.2011.07.033 10.1016/j.ygeno.2004.08.010 10.1073/pnas.88.13.5680 10.1136/ard.2004.031641 10.1038/nature25986 10.1111/j.1440-1711.2005.01383.x 10.1084/jem.20112607 10.1002/path.1778 10.1016/j.imbio.2010.12.005 10.1111/j.1600-0463.2009.02568.x 10.1084/jem.20100587 10.1182/blood-2003-07-2427 10.1038/s41467-017-02683-x 10.3748/wjg.v25.i15.1865 10.1038/emi.2017.21 10.1158/0008-5472.CAN-14-0037-T 10.1186/s10020-018-0053-2 10.1038/nrmicro1710 10.1016/S0021-9258(18)70011-2 10.1158/0008-5472.CAN-13-0992 10.1073/pnas.052706699 10.1007/s00109-012-0882-3 10.1371/journal.ppat.0020116 10.1155/2017/9029327 10.1038/32588 10.1172/JCI84431 10.1083/jcb.200606027 10.1016/j.immuni.2019.01.021 10.1111/j.1462-5822.2009.01340.x 10.4049/jimmunol.1600266 10.1016/j.jim.2005.10.012 |
| ContentType | Journal Article |
| Copyright | 2020 Elsevier Inc. Copyright © 2020 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2020 Elsevier Inc. – notice: Copyright © 2020 Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.cmet.2020.08.002 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1932-7420 |
| EndPage | 536 |
| ExternalDocumentID | 32853548 10_1016_j_cmet_2020_08_002 S1550413120304150 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: Wellcome Trust grantid: 109443/Z/15/Z |
| GroupedDBID | --- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 53G 5GY 62- 6J9 7-5 AACTN AAEDW AAFTH AAIAV AAKRW AAKUH AALRI AAUCE AAVLU AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ADBBV ADEZE ADJPV AEFWE AENEX AEXQZ AFTJW AGKMS AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS F5P FCP FDB FEDTE FIRID HVGLF IHE IXB J1W JIG M3Z M41 O-L O9- OK1 P2P RCE ROL RPZ SES SSZ TR2 UNMZH WQ6 ZA5 AAEDT AAIKJ AAMRU AAYWO AAYXX ABDGV ACVFH ADCNI ADVLN AEUPX AFPUW AGCQF AGHFR AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION EJD HZ~ OZT RIG EFKBS NPM 7X8 |
| ID | FETCH-LOGICAL-c466t-5bb74d0705d8128cee99e26f53d6cc7b7a87303410e61af4e4c8b79fce1ac1403 |
| IEDL.DBID | IXB |
| ISSN | 1550-4131 1932-7420 |
| IngestDate | Mon Jul 21 09:39:27 EDT 2025 Mon Jul 21 06:02:46 EDT 2025 Thu Apr 24 23:06:34 EDT 2025 Tue Jul 01 03:58:19 EDT 2025 Fri Feb 23 02:45:24 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Copyright © 2020 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c466t-5bb74d0705d8128cee99e26f53d6cc7b7a87303410e61af4e4c8b79fce1ac1403 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | http://www.cell.com/article/S1550413120304150/pdf |
| PMID | 32853548 |
| PQID | 2438676593 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_2438676593 pubmed_primary_32853548 crossref_primary_10_1016_j_cmet_2020_08_002 crossref_citationtrail_10_1016_j_cmet_2020_08_002 elsevier_sciencedirect_doi_10_1016_j_cmet_2020_08_002 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-10-06 |
| PublicationDateYYYYMMDD | 2020-10-06 |
| PublicationDate_xml | – month: 10 year: 2020 text: 2020-10-06 day: 06 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell metabolism |
| PublicationTitleAlternate | Cell Metab |
| PublicationYear | 2020 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Liu, Zhang, Chen, Cheng, Liu, Xia, Chen, Zhu, Li, Cao (bib90) 2019; 50 Frede, Stockmann, Freitag, Fandrey (bib47) 2006; 396 Greijer, van der Groep, Kemming, Shvarts, Semenza, Meijer, van de Wiel, Belien, van Diest, van der Wall (bib58) 2005; 206 Rossi, Sawatzky, Walker, Ward, Sheldrake, Riley, Caldicott, Martinez-Losa, Walker, Duffin (bib124) 2006; 12 Clambey, McNamee, Westrich, Glover, Campbell, Jedlicka, de Zoeten, Cambier, Stenmark, Colgan, Eltzschig (bib24) 2012; 109 Giatromanolaki, Sivridis, Maltezos, Papazoglou, Simopoulos, Gatter, Harris, Koukourakis (bib52) 2003; 56 Yoo, Oh, Park, Cho, Lee, Park, Kim, Yu, Seong, Lee (bib160) 2003; 278 Shalova, Lim, Chittezhath, Zinkernagel, Beasley, Hernández-Jiménez, Toledano, Cubillos-Zapata, Rapisarda, Chen (bib133) 2015; 42 Emmrich, Seyfarth, Fleig, Emmrich (bib38) 1991; 338 Gleadle, Ratcliffe (bib53) 1997; 89 Makita, Ishiguro, Suzuki, Nara (bib94) 2017; 69 Zhou, Ivanov, Spolski, Min, Shenderov, Egawa, Levy, Leonard, Littman (bib167) 2007; 8 Shehade, Acolty, Moser, Oldenhove (bib134) 2015; 195 Palazon, Goldrath, Nizet, Johnson (bib116) 2014; 41 Barsoum, Hamilton, Li, Cotechini, Miles, Siemens, Graham (bib7) 2011; 71 Fisher (bib43) 1983; 173 O’Rourke, Dachs, Gleadle, Maxwell, Pugh, Stratford, Wood, Ratcliffe (bib112) 1997; 9 Fried, Goldwasser, Jacobson, Plzak (bib48) 1957; 94 Naldini, Morena, Pucci, Miglietta, Riboldi, Sozzani, Carraro (bib110) 2012; 227 Hitchon, El-Gabalawy (bib66) 2004; 6 Lee, Elly, Park, Liu (bib86) 2015; 42 Xie, Robles, Mukherjee, Zhang, Feldbrügge, Csizmadia, Wu, Enjyoji, Moss, Otterbein (bib157) 2018; 94 Guo, Zhu, Zhang, Meng, Zhu, Han, Zhou, Hu, Wang (bib60) 2017; 6 Ehirchiou, Xiong, Xu, Chen, Shi, Zhang (bib35) 2007; 204 Takeda, O’Dea, Doedens, Kim, Weidemann, Stockmann, Asagiri, Simon, Hoffmann, Johnson (bib142) 2010; 24 Finlay, Rosenzweig, Sinclair, Feijoo-Carnero, Hukelmann, Rolf, Panteleyev, Okkenhaug, Cantrell (bib42) 2012; 209 Thornton, Lane, Borghaei, Pease, Caro, Mochan (bib147) 2000; 350 Zhao, Darmanin, Fu, Chen, Cui, Wang, Okada, Hamada, Hattori, Kondo (bib164) 2005; 35 Evans, Koch (bib39) 2003; 195 Knight, Braverman, Asfaha, Gronert, Stanley (bib80) 2018; 14 Flück, Breves, Fandrey, Winning (bib45) 2016; 9 Thibult, Mamessier, Gertner-Dardenne, Pastor, Just-Landi, Xerri, Chetaille, Olive (bib144) 2013; 25 Imtiyaz, Williams, Hickey, Patel, Durham, Yuan, Hammond, Gimotty, Keith, Simon (bib73) 2010; 120 Alonso, Serrano, Bermejo, Corral (bib2) 2019; 335 Corzo, Condamine, Lu, Cotter, Youn, Cheng, Cho, Celis, Quiceno, Padhya (bib27) 2010; 207 McInturff, Cody, Elliott, Glenn, Rowley, Rondina, Yost (bib99) 2012; 120 Cho, Raybuck, Blagih, Kemboi, Haase, Jones, Boothby (bib22) 2019; 116 Selak, Armour, MacKenzie, Boulahbel, Watson, Mansfield, Pan, Simon, Thompson, Gottlieb (bib128) 2005; 7 Filippi, Morena, Aldinucci, Carraro, Sozzani, Naldini (bib41) 2014; 229 Völlger, Akong-Moore, Cox, Goldmann, Wang, Schäfer, Naim, Nizet, von Köckritz-Blickwede (bib149) 2016; 36 Mimouna, Gonçalvès, Barnich, Darfeuille-Michaud, Hofman, Vouret-Craviari (bib106) 2011; 2 Abbott, Thayer, Labuda, Silva, Philbrook, Cain, Kojima, Hatfield, Sethumadhavan, Ohta (bib1) 2016; 197 Hu, Shi, Mu, Zhu, Li, Ma, Li, Jia, Yang, Li, Li (bib69) 2013; 8 Vaupel, Mayer (bib148) 2007; 26 Corcoran, O’Neill (bib26) 2016; 126 Christofk, Vander Heiden, Harris, Ramanathan, Gerszten, Wei, Fleming, Schreiber, Cantley (bib23) 2008; 452 Elshabrawy, Chen, Volin, Ravella, Virupannavar, Shahrara (bib37) 2015; 18 Deshmane, Mukerjee, Fan, Del Valle, Michiels, Sweet, Rom, Khalili, Rappaport, Amini, Sawaya (bib32) 2009; 284 Karhausen, Furuta, Tomaszewski, Johnson, Colgan, Haase (bib76) 2004; 114 Stronkhorst, Radema, Yong, Bijl, ten Berge, Tytgat, van Deventer (bib139) 1997; 40 Wang, Liu, Lian, Zhang, Wang, Jiang (bib155) 2017; 2017 Singh, Mukhopadhyay, Biswas, Singh, Mukhopadhyay (bib136) 2012; 7 Schäfer, Frede, Winning, Bick, Roshangar, Fandrey, Peters, Adamzik (bib126) 2013; 118 Degrossoli, Bosetto, Lima, Giorgio (bib31) 2007; 114 Liu, Jiang, Liu, Wang, Qian, Zheng, Deng, Huang, Xu, Wang, Chu (bib88) 2015; 62 Palsson-McDermott, Curtis, Goel, Lauterbach, Sheedy, Gleeson, van den Bosch, Quinn, Domingo-Fernandez, Johnston (bib118) 2015; 21 Mills, Kelly, Logan, Costa, Varma, Bryant, Tourlomousis, Däbritz, Gottlieb, Latorre (bib104) 2016; 167 Kwon, Moon, Kwon, Park, Kim (bib85) 2017; 81 Mesquita, Ferreira, Moreira, Kluck, Barbosa, Torrado, Dinis-Oliveira, Gonçalves, Beauparlant, Droit (bib102) 2020; 30 Gleeson, Sheedy, Palsson-McDermott, Triglia, O’Leary, O’Sullivan, O’Neill, Keane (bib54) 2016; 196 Noman, Desantis, Janji, Hasmim, Karray, Dessen, Bronte, Chouaib (bib111) 2014; 211 Liu, Bi, Xue, Zhang, Yang, Chen, Lu, Zhang, Liu, Wang (bib87) 2015; 112 Braverman, Sogi, Benjamin, Nomura, Stanley (bib15) 2016; 197 Clever, Roychoudhuri, Constantinides, Askenase, Sukumar, Klebanoff, Eil, Hickman, Yu, Pan (bib25) 2016; 166 Semenza (bib129) 2002; 8 Ma, Deng, Liu, Mao, Yu, Bu, Kulkarni, Zhang, Sun (bib93) 2017; 16 Bosseto, Palma, Covas, Giorgio (bib13) 2010; 118 Cai, Knight, Verma, Zald, Robertson (bib19) 2006; 2 Wang, Liu, Zhu, Liu, Zhang, Guo, Wang, Li, Ma, Sun (bib154) 2010; 47 Hammami, Abidin, Heinonen, Stäger (bib62) 2018; 8 Wang, Jiang, Rue, Semenza (bib153) 1995; 92 Barsoum, Smallwood, Siemens, Graham (bib8) 2014; 74 Hua, Dias (bib72) 2016; 7 Ohh, Park, Ivan, Hoffman, Kim, Huang, Pavletich, Chau, Kaelin (bib113) 2000; 2 Graeber, Osmanian, Jacks, Housman, Koch, Lowe, Giaccia (bib57) 1996; 379 Michalek, Gerriets, Jacobs, Macintyre, MacIver, Mason, Sullivan, Nichols, Rathmell (bib103) 2011; 186 Mazurek, Boschek, Hugo, Eigenbrodt (bib98) 2005; 15 Doedens, Phan, Stradner, Fujimoto, Nguyen, Yang, Johnson, Goldrath (bib34) 2013; 14 Semenza (bib130) 2012; 148 Yipp, Kubes (bib159) 2013; 122 Banchereau, Steinman (bib5) 1998; 392 Fliesser, Wallstein, Kurzai, Einsele, Löffler (bib44) 2016; 59 Hu, Liu, Xu, Li, Liu, Shi, Su, Qiu, Zhang, Yang (bib70) 2016; 46 Mills, Ryan, Prag, Dikovskaya, Menon, Zaslona, Jedrychowski, Costa, Higgins, Hams (bib105) 2018; 556 Peng, Yin, Chhangawala, Xu, Leslie, Li (bib119) 2016; 354 Biniecka, Canavan, McGarry, Gao, McCormick, Cregan, Gallagher, Smith, Phelan, Ryan (bib10) 2016; 75 Zhao, Li, Yang, Shao, Wang, Liu, Song, Song, Zhang, Qu (bib165) 2008; 45 Cummins, Seeballuck, Keely, Mangan, Callanan, Fallon, Taylor (bib29) 2008; 134 Schatz, Strüssmann, Mahnke, Schley, Waldner, Ritter, Wild, Willam, Dehne, Brüne (bib127) 2016; 197 Keely, Campbell, Baird, Hansbro, Shalwitz, Kotsakis, McNamee, Eltzschig, Kominsky, Colgan (bib77) 2014; 7 Brinkmann, Zychlinsky (bib16) 2007; 5 Höckel, Vaupel (bib68) 2001; 93 Sun, Fu, Lin, Sun, Xia, Lin, Liu, Zhang, Yang, Xue (bib140) 2020; 145 Qian, Hong, Wang, Wang, Lu, Li, Liu, Chu (bib122) 2019; 111 Thompson, Elks, Marriott, Eamsamarng, Higgins, Lewis, Williams, Parmar, Shaw, McGrath (bib146) 2014; 123 Zhang, Sattler, Tonon, Grabher, Lababidi, Zimmerhackl, Raab, Vallet, Zhou, Cartron (bib162) 2009; 69 Liu, Pu, Cron, Deng, Kline, Frazier, Xu, Peng, Fu, Xu (bib89) 2015; 21 Qu, Yang, Kong, Qi, Lam, Yan, Li, Zhang, Lu (bib123) 2005; 83 Mimouna, Bazin, Mograbi, Darfeuille-Michaud, Brest, Hofman, Vouret-Craviari (bib107) 2014; 10 Gondin, Théret, Duhamel, Pegan, Mathieu, Peyssonnaux, Cuvellier, Latroche, Chazaud, Bendahan, Mounier (bib55) 2015; 194 Zinkernagel, Peyssonnaux, Johnson, Nizet (bib168) 2008; 197 Fuchs, Abed, Goosmann, Hurwitz, Schulze, Wahn, Weinrauch, Brinkmann, Zychlinsky (bib49) 2007; 176 Köhler, Reizis, Johnson, Weighardt, Förster (bib81) 2012; 42 Harnanik, Soeroso, Suryokusumo, Juliandhy (bib64) 2020; 35 Peyssonnaux, Datta, Cramer, Doedens, Theodorakis, Gallo, Hurtado-Ziola, Nizet, Johnson (bib120) 2005; 115 Dang, Barbi, Yang, Jinasena, Yu, Zheng, Bordman, Fu, Kim, Yen (bib30) 2011; 146 Zhan, Chen, Luo, Shi, Zhang (bib161) 2018; 24 Meng, Grötsch, Luo, Knaup, Wiesener, Chen, Jantsch, Fillatreau, Schett, Bozec (bib101) 2018; 9 Takahashi, Akutagawa, Fukumoto, Tsukiyama, Ohe, Takahashi, Fukuchi, Saijo, Nishio (bib141) 2002; 98 Hitosugi, Kang, Vander Heiden, Chung, Elf, Lythgoe, Dong, Lonial, Wang, Chen (bib67) 2009; 2 Jin, Ahmed, Okazaki (bib75) 2011; 350 Staples, Sotoodehnejadnematalahi, Pearson, Frankenberger, Francescut, Ziegler-Heitbrock, Burke (bib138) 2011; 216 Fasching, Stradner, Graninger, Dejaco, Fessler (bib40) 2017; 22 Konisti, Kiriakidis, Paleolog (bib84) 2012; 8 Paardekooper, Bendix, Ottria, de Haer, Ter Beest, Radstake, Marut, van den Bogaart (bib115) 2018; 38 Okumura, Hollands, Tran, Olson, Dahesh, von Köckritz-Blickwede, Thienphrapa, Corle, Jeung, Kotsakis (bib114) 2012; 90 Kojima, Gu, Nomura, Caldwell, Kobata, Carmeliet, Semenza, Sitkovsky (bib82) 2002; 99 Kirchner, Möller, Klinger, Solbach, Laskay, Behnen (bib78) 2012; 2012 Shi, Wang, Huang, Vogel, Neale, Green, Chi (bib135) 2011; 208 Barrero, Datta, Sen, Deshmane, Amini, Khalili, Merali (bib6) 2013; 8 Ding, Ma, Chen, Liu, Cai, Hu, Xiang, Nath, Zhang, Ye (bib33) 2013; 4 Mecklenburgh, Walmsley, Cowburn, Wiesener, Reed, Upton, Deighton, Greening, Chilvers (bib100) 2002; 100 Lund-Olesen (bib91) 1970; 13 Wang, Semenza (bib152) 1995; 270 Elia, Cappello, Puppo, Fraone, Vanni, Eva, Musso, Novelli, Varesio, Giovarelli (bib36) 2008; 84 Gálvez (bib51) 2014; 2014 Guthrie, McPhail, Henson, Johnston (bib61) 1984; 160 Tannahill, Curtis, Adamik, Palsson-McDermott, McGettrick, Goel, Frezza, Bernard, Kelly, Foley (bib143) 2013; 496 Bosco, Puppo, Blengio, Fraone, Cappello, Giovarelli, Varesio (bib12) 2008; 213 Hu, Zhang, Chen, Cheng, Chen, Zheng, Lin, Zhu, Zhang, Bai (bib71) 2020; 19 Semenza, Wang (bib131) 1992; 12 Brinkmann, Reichard, Goosmann, Fauler, Uhlemann, Weiss, Weinrauch, Zychlinsky (bib17) 2004; 303 Peyssonnaux, Cejudo-Martin, Doedens, Zinkernagel, Johnson, Nizet (bib121) 2007; 178 Werth, Beerlage, Rosenberger, Yazdi, Edelmann, Amr, Bernhardt, von Eiff, Becker, Schäfer (bib156) 2010; 5 Semenza, Nejfelt, Chi, Antonarakis (bib132) 1991; 88 Hams, Saunders, Cummins, O’Connor, Tambuwala, Gallagher, Byrne, Campos-Torres, Moynagh, Jobin (bib63) 2011; 36 Gaber, Dziurla, Tripmacher, Burmester, Buttgereit (bib50) 2005; 64 Walmsley, Pri Palazon (10.1016/j.cmet.2020.08.002_bib116) 2014; 41 Kirchner (10.1016/j.cmet.2020.08.002_bib78) 2012; 2012 Harnanik (10.1016/j.cmet.2020.08.002_bib64) 2020; 35 Zhou (10.1016/j.cmet.2020.08.002_bib167) 2007; 8 Cramer (10.1016/j.cmet.2020.08.002_bib28) 2003; 112 Qu (10.1016/j.cmet.2020.08.002_bib123) 2005; 83 Mesquita (10.1016/j.cmet.2020.08.002_bib102) 2020; 30 Flynn (10.1016/j.cmet.2020.08.002_bib46) 1993; 178 Barsoum (10.1016/j.cmet.2020.08.002_bib7) 2011; 71 Wang (10.1016/j.cmet.2020.08.002_bib152) 1995; 270 Evans (10.1016/j.cmet.2020.08.002_bib39) 2003; 195 Palazon (10.1016/j.cmet.2020.08.002_bib117) 2017; 32 Takahashi (10.1016/j.cmet.2020.08.002_bib141) 2002; 98 Ben-Shoshan (10.1016/j.cmet.2020.08.002_bib9) 2008; 38 Shalova (10.1016/j.cmet.2020.08.002_bib133) 2015; 42 Christofk (10.1016/j.cmet.2020.08.002_bib23) 2008; 452 Cheng (10.1016/j.cmet.2020.08.002_bib20) 2014; 345 McInturff (10.1016/j.cmet.2020.08.002_bib99) 2012; 120 Elshabrawy (10.1016/j.cmet.2020.08.002_bib37) 2015; 18 Fisher (10.1016/j.cmet.2020.08.002_bib43) 1983; 173 Höckel (10.1016/j.cmet.2020.08.002_bib68) 2001; 93 Deshmane (10.1016/j.cmet.2020.08.002_bib32) 2009; 284 Zhan (10.1016/j.cmet.2020.08.002_bib161) 2018; 24 Cai (10.1016/j.cmet.2020.08.002_bib19) 2006; 2 Shehade (10.1016/j.cmet.2020.08.002_bib134) 2015; 195 Shi (10.1016/j.cmet.2020.08.002_bib135) 2011; 208 Peyssonnaux (10.1016/j.cmet.2020.08.002_bib121) 2007; 178 Wang (10.1016/j.cmet.2020.08.002_bib155) 2017; 2017 Martínez-García (10.1016/j.cmet.2020.08.002_bib96) 2019; 10 Hu (10.1016/j.cmet.2020.08.002_bib69) 2013; 8 Liu (10.1016/j.cmet.2020.08.002_bib87) 2015; 112 Schatz (10.1016/j.cmet.2020.08.002_bib127) 2016; 197 Kwon (10.1016/j.cmet.2020.08.002_bib85) 2017; 81 Noman (10.1016/j.cmet.2020.08.002_bib111) 2014; 211 Sun (10.1016/j.cmet.2020.08.002_bib140) 2020; 145 Bosco (10.1016/j.cmet.2020.08.002_bib12) 2008; 213 Hu (10.1016/j.cmet.2020.08.002_bib70) 2016; 46 Gleadle (10.1016/j.cmet.2020.08.002_bib53) 1997; 89 Singh (10.1016/j.cmet.2020.08.002_bib136) 2012; 7 Zhao (10.1016/j.cmet.2020.08.002_bib165) 2008; 45 Semenza (10.1016/j.cmet.2020.08.002_bib132) 1991; 88 Elia (10.1016/j.cmet.2020.08.002_bib36) 2008; 84 Liu (10.1016/j.cmet.2020.08.002_bib89) 2015; 21 Yipp (10.1016/j.cmet.2020.08.002_bib159) 2013; 122 Alonso (10.1016/j.cmet.2020.08.002_bib2) 2019; 335 Harris (10.1016/j.cmet.2020.08.002_bib65) 2007; 179 Ohh (10.1016/j.cmet.2020.08.002_bib113) 2000; 2 Soto-Pantoja (10.1016/j.cmet.2020.08.002_bib137) 2014; 74 Kojima (10.1016/j.cmet.2020.08.002_bib83) 2010; 184 Zhang (10.1016/j.cmet.2020.08.002_bib162) 2009; 69 Peng (10.1016/j.cmet.2020.08.002_bib119) 2016; 354 Moin (10.1016/j.cmet.2020.08.002_bib108) 2009; 11 Thiel (10.1016/j.cmet.2020.08.002_bib145) 2007; 2 Keely (10.1016/j.cmet.2020.08.002_bib77) 2014; 7 Okumura (10.1016/j.cmet.2020.08.002_bib114) 2012; 90 Werth (10.1016/j.cmet.2020.08.002_bib156) 2010; 5 Gleeson (10.1016/j.cmet.2020.08.002_bib54) 2016; 196 Mills (10.1016/j.cmet.2020.08.002_bib104) 2016; 167 Völlger (10.1016/j.cmet.2020.08.002_bib149) 2016; 36 Gálvez (10.1016/j.cmet.2020.08.002_bib51) 2014; 2014 Degrossoli (10.1016/j.cmet.2020.08.002_bib31) 2007; 114 Yoo (10.1016/j.cmet.2020.08.002_bib160) 2003; 278 Braverman (10.1016/j.cmet.2020.08.002_bib15) 2016; 197 Vaupel (10.1016/j.cmet.2020.08.002_bib148) 2007; 26 Barrero (10.1016/j.cmet.2020.08.002_bib6) 2013; 8 Stronkhorst (10.1016/j.cmet.2020.08.002_bib139) 1997; 40 Walmsley (10.1016/j.cmet.2020.08.002_bib151) 2006; 108 Knight (10.1016/j.cmet.2020.08.002_bib80) 2018; 14 Zheng (10.1016/j.cmet.2020.08.002_bib166) 2019; 25 Gaber (10.1016/j.cmet.2020.08.002_bib50) 2005; 64 Palsson-McDermott (10.1016/j.cmet.2020.08.002_bib118) 2015; 21 Kirchner (10.1016/j.cmet.2020.08.002_bib79) 2013; 2013 Mimouna (10.1016/j.cmet.2020.08.002_bib107) 2014; 10 Giatromanolaki (10.1016/j.cmet.2020.08.002_bib52) 2003; 56 Qian (10.1016/j.cmet.2020.08.002_bib122) 2019; 111 Finlay (10.1016/j.cmet.2020.08.002_bib42) 2012; 209 Yeh (10.1016/j.cmet.2020.08.002_bib158) 2011; 36 Thibult (10.1016/j.cmet.2020.08.002_bib144) 2013; 25 Guak (10.1016/j.cmet.2020.08.002_bib59) 2018; 9 Fried (10.1016/j.cmet.2020.08.002_bib48) 1957; 94 Hitchon (10.1016/j.cmet.2020.08.002_bib66) 2004; 6 Clever (10.1016/j.cmet.2020.08.002_bib25) 2016; 166 Hams (10.1016/j.cmet.2020.08.002_bib63) 2011; 36 Kojima (10.1016/j.cmet.2020.08.002_bib82) 2002; 99 Fasching (10.1016/j.cmet.2020.08.002_bib40) 2017; 22 Hammami (10.1016/j.cmet.2020.08.002_bib62) 2018; 8 Mecklenburgh (10.1016/j.cmet.2020.08.002_bib100) 2002; 100 Brinkmann (10.1016/j.cmet.2020.08.002_bib16) 2007; 5 Luo (10.1016/j.cmet.2020.08.002_bib92) 2011; 145 Mazurek (10.1016/j.cmet.2020.08.002_bib98) 2005; 15 Banchereau (10.1016/j.cmet.2020.08.002_bib5) 1998; 392 Flück (10.1016/j.cmet.2020.08.002_bib45) 2016; 9 Rossi (10.1016/j.cmet.2020.08.002_bib124) 2006; 12 Clambey (10.1016/j.cmet.2020.08.002_bib24) 2012; 109 Jin (10.1016/j.cmet.2020.08.002_bib75) 2011; 350 Brouwer (10.1016/j.cmet.2020.08.002_bib18) 2009; 27 Konisti (10.1016/j.cmet.2020.08.002_bib84) 2012; 8 Bosseto (10.1016/j.cmet.2020.08.002_bib13) 2010; 118 Paardekooper (10.1016/j.cmet.2020.08.002_bib115) 2018; 38 Baay-Guzman (10.1016/j.cmet.2020.08.002_bib4) 2018; 13 Emmrich (10.1016/j.cmet.2020.08.002_bib38) 1991; 338 Hitosugi (10.1016/j.cmet.2020.08.002_bib67) 2009; 2 Branitzki-Heinemann (10.1016/j.cmet.2020.08.002_bib14) 2016; 7 Semenza (10.1016/j.cmet.2020.08.002_bib131) 1992; 12 Tannahill (10.1016/j.cmet.2020.08.002_bib143) 2013; 496 Abbott (10.1016/j.cmet.2020.08.002_bib1) 2016; 197 Goth (10.1016/j.cmet.2020.08.002_bib56) 2006; 308 Semenza (10.1016/j.cmet.2020.08.002_bib129) 2002; 8 Lund-Olesen (10.1016/j.cmet.2020.08.002_bib91) 1970; 13 Walmsley (10.1016/j.cmet.2020.08.002_bib150) 2005; 201 Zinkernagel (10.1016/j.cmet.2020.08.002_bib168) 2008; 197 Cho (10.1016/j.cmet.2020.08.002_bib21) 2016; 537 Filippi (10.1016/j.cmet.2020.08.002_bib41) 2014; 229 Selak (10.1016/j.cmet.2020.08.002_bib128) 2005; 7 Mancino (10.1016/j.cmet.2020.08.002_bib95) 2008; 112 Peyssonnaux (10.1016/j.cmet.2020.08.002_bib120) 2005; 115 Ding (10.1016/j.cmet.2020.08.002_bib33) 2013; 4 Köhler (10.1016/j.cmet.2020.08.002_bib81) 2012; 42 Guthrie (10.1016/j.cmet.2020.08.002_bib61) 1984; 160 Jantsch (10.1016/j.cmet.2020.08.002_bib74) 2008; 180 Barsoum (10.1016/j.cmet.2020.08.002_bib8) 2014; 74 Michalek (10.1016/j.cmet.2020.08.002_bib103) 2011; 186 Makita (10.1016/j.cmet.2020.08.002_bib94) 2017; 69 Wang (10.1016/j.cmet.2020.08.002_bib154) 2010; 47 Corzo (10.1016/j.cmet.2020.08.002_bib27) 2010; 207 Wang (10.1016/j.cmet.2020.08.002_bib153) 1995; 92 Zhao (10.1016/j.cmet.2020.08.002_bib164) 2005; 35 Schäfer (10.1016/j.cmet.2020.08.002_bib126) 2013; 118 Fuchs (10.1016/j.cmet.2020.08.002_bib49) 2007; 176 Ma (10.1016/j.cmet.2020.08.002_bib93) 2017; 16 Morote-Garcia (10.1016/j.cmet.2020.08.002_bib109) 2008; 111 Corcoran (10.1016/j.cmet.2020.08.002_bib26) 2016; 126 Greijer (10.1016/j.cmet.2020.08.002_bib58) 2005; 206 Brinkmann (10.1016/j.cmet.2020.08.002_bib17) 2004; 303 Zhang (10.1016/j.cmet.2020.08.002_bib163) 2015; 112 Maxwell (10.1016/j.cmet.2020.08.002_bib97) 1999; 399 Blouin (10.1016/j.cmet.2020.08.002_bib11) 2004; 103 Thompson (10.1016/j.cmet.2020.08.002_bib146) 2014; 123 Doedens (10.1016/j.cmet.2020.08.002_bib34) 2013; 14 Lee (10.1016/j.cmet.2020.08.002_bib86) 2015; 42 Liu (10.1016/j.cmet.2020.08.002_bib88) 2015; 62 Karhausen (10.1016/j.cmet.2020.08.002_bib76) 2004; 114 Liu (10.1016/j.cmet.2020.08.002_bib90) 2019; 50 Hua (10.1016/j.cmet.2020.08.002_bib72) 2016; 7 Sbarra (10.1016/j.cmet.2020.08.002_bib125) 1959; 234 Hu (10.1016/j.cmet.2020.08.002_bib71) 2020; 19 Ehirchiou (10.1016/j.cmet.2020.08.002_bib35) 2007; 204 Biniecka (10.1016/j.cmet.2020.08.002_bib10) 2016; 75 Cummins (10.1016/j.cmet.2020.08.002_bib29) 2008; 134 O’Rourke (10.1016/j.cmet.2020.08.002_bib112) 1997; 9 Gondin (10.1016/j.cmet.2020.08.002_bib55) 2015; 194 Meng (10.1016/j.cmet.2020.08.002_bib101) 2018; 9 Naldini (10.1016/j.cmet.2020.08.002_bib110) 2012; 227 Staples (10.1016/j.cmet.2020.08.002_bib138) 2011; 216 Xie (10.1016/j.cmet.2020.08.002_bib157) 2018; 94 Graeber (10.1016/j.cmet.2020.08.002_bib57) 1996; 379 Guo (10.1016/j.cmet.2020.08.002_bib60) 2017; 6 Imtiyaz (10.1016/j.cmet.2020.08.002_bib73) 2010; 120 Altenberg (10.1016/j.cmet.2020.08.002_bib3) 2004; 84 Thornton (10.1016/j.cmet.2020.08.002_bib147) 2000; 350 Mimouna (10.1016/j.cmet.2020.08.002_bib106) 2011; 2 Semenza (10.1016/j.cmet.2020.08.002_bib130) 2012; 148 Takeda (10.1016/j.cmet.2020.08.002_bib142) 2010; 24 Cho (10.1016/j.cmet.2020.08.002_bib22) 2019; 116 Fliesser (10.1016/j.cmet.2020.08.002_bib44) 2016; 59 Frede (10.1016/j.cmet.2020.08.002_bib47) 2006; 396 Mills (10.1016/j.cmet.2020.08.002_bib105) 2018; 556 Dang (10.1016/j.cmet.2020.08.002_bib30) 2011; 146 |
| References_xml | – volume: 452 start-page: 230 year: 2008 end-page: 233 ident: bib23 article-title: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth publication-title: Nature – volume: 45 start-page: 2187 year: 2008 end-page: 2195 ident: bib165 article-title: Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway publication-title: Mol. Immunol. – volume: 24 start-page: 55 year: 2018 ident: bib161 article-title: Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis publication-title: Mol. Med. – volume: 2012 start-page: 849136 year: 2012 ident: bib78 article-title: The impact of various reactive oxygen species on the formation of neutrophil extracellular traps publication-title: Mediators Inflamm. – volume: 284 start-page: 11364 year: 2009 end-page: 11373 ident: bib32 article-title: Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression publication-title: J. Biol. Chem. – volume: 100 start-page: 3008 year: 2002 end-page: 3016 ident: bib100 article-title: Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis publication-title: Blood – volume: 115 start-page: 1806 year: 2005 end-page: 1815 ident: bib120 article-title: HIF-1alpha expression regulates the bactericidal capacity of phagocytes publication-title: J. Clin. Invest. – volume: 114 start-page: 119 year: 2007 end-page: 125 ident: bib31 article-title: Expression of hypoxia-inducible factor 1alpha in mononuclear phagocytes infected with Leishmania amazonensis publication-title: Immunol. Lett. – volume: 83 start-page: 668 year: 2005 end-page: 673 ident: bib123 article-title: Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells publication-title: Immunol. Cell Biol. – volume: 56 start-page: 209 year: 2003 end-page: 213 ident: bib52 article-title: Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease publication-title: J. Clin. Pathol. – volume: 112 start-page: E6215 year: 2015 end-page: E6223 ident: bib163 article-title: HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells publication-title: Proc. Natl. Acad. Sci. USA – volume: 90 start-page: 1079 year: 2012 end-page: 1089 ident: bib114 article-title: A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection publication-title: J. Mol. Med. (Berl.) – volume: 186 start-page: 3299 year: 2011 end-page: 3303 ident: bib103 article-title: Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets publication-title: J. Immunol. – volume: 42 start-page: 484 year: 2015 end-page: 498 ident: bib133 article-title: Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α publication-title: Immunity – volume: 196 start-page: 2444 year: 2016 end-page: 2449 ident: bib54 article-title: Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication publication-title: J. Immunol. – volume: 396 start-page: 517 year: 2006 end-page: 527 ident: bib47 article-title: Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB publication-title: Biochem. J. – volume: 206 start-page: 291 year: 2005 end-page: 304 ident: bib58 article-title: Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1) publication-title: J. Pathol. – volume: 111 start-page: 162 year: 2019 end-page: 171 ident: bib122 article-title: Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease publication-title: Mol. Immunol. – volume: 74 start-page: 6771 year: 2014 end-page: 6783 ident: bib137 article-title: CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy publication-title: Cancer Res. – volume: 50 start-page: 600 year: 2019 end-page: 615.e15 ident: bib90 article-title: CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1α-mediated glycolysis publication-title: Immunity – volume: 35 start-page: e90 year: 2020 ident: bib64 article-title: Effects of hyperbaric oxygen on T helper 17/regulatory T polarization in antigen and collagen-induced arthritis: hypoxia-inducible factor-1α as a target publication-title: Oman Med. J. – volume: 94 start-page: 122 year: 2018 end-page: 133 ident: bib157 article-title: HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn’s disease publication-title: J. Autoimmun. – volume: 120 start-page: 3118 year: 2012 end-page: 3125 ident: bib99 article-title: Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α publication-title: Blood – volume: 38 year: 2018 ident: bib115 article-title: Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8 publication-title: Biosci. Rep. – volume: 537 start-page: 234 year: 2016 end-page: 238 ident: bib21 article-title: Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system publication-title: Nature – volume: 15 start-page: 300 year: 2005 end-page: 308 ident: bib98 article-title: Pyruvate kinase type M2 and its role in tumor growth and spreading publication-title: Semin. Cancer Biol. – volume: 13 start-page: 785 year: 2018 end-page: 798 ident: bib4 article-title: Dual role of hypoxia-inducible factor 1 α in experimental pulmonary tuberculosis: its implication as a new therapeutic target publication-title: Future Microbiol. – volume: 94 start-page: 237 year: 1957 end-page: 241 ident: bib48 article-title: Studies on erythropoiesis. III. Factors controlling erythropoietin production publication-title: Proc. Soc. Exp. Biol. Med. – volume: 234 start-page: 1355 year: 1959 end-page: 1362 ident: bib125 article-title: The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes publication-title: J. Biol. Chem. – volume: 88 start-page: 5680 year: 1991 end-page: 5684 ident: bib132 article-title: Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene publication-title: Proc. Natl. Acad. Sci. USA – volume: 211 start-page: 781 year: 2014 end-page: 790 ident: bib111 article-title: PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation publication-title: J. Exp. Med. – volume: 40 start-page: 320 year: 1997 end-page: 327 ident: bib139 article-title: CD4 antibody treatment in patients with active Crohn’s disease: a phase 1 dose finding study publication-title: Gut – volume: 9 start-page: 379 year: 2016 end-page: 390 ident: bib45 article-title: Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis publication-title: Mucosal Immunol. – volume: 7 start-page: 184 year: 2016 ident: bib72 article-title: Hypoxia-inducible factor (HIF) as a target for novel therapies in rheumatoid arthritis publication-title: Front. Pharmacol. – volume: 8 start-page: 153 year: 2012 end-page: 162 ident: bib84 article-title: Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis publication-title: Nat. Rev. Rheumatol. – volume: 111 start-page: 5571 year: 2008 end-page: 5580 ident: bib109 article-title: HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak publication-title: Blood – volume: 197 start-page: 4014 year: 2016 end-page: 4020 ident: bib1 article-title: Germinal center hypoxia potentiates immunoglobulin class switch recombination publication-title: J. Immunol. – volume: 556 start-page: 113 year: 2018 end-page: 117 ident: bib105 article-title: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 publication-title: Nature – volume: 8 start-page: S62 year: 2002 end-page: S67 ident: bib129 article-title: HIF-1 and tumor progression: pathophysiology and therapeutics publication-title: Trends Mol. Med. – volume: 207 start-page: 2439 year: 2010 end-page: 2453 ident: bib27 article-title: HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment publication-title: J. Exp. Med. – volume: 42 start-page: 1062 year: 2015 end-page: 1074 ident: bib86 article-title: E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1α to maintain regulatory T cell stability and suppressive capacity publication-title: Immunity – volume: 112 start-page: 3723 year: 2008 end-page: 3734 ident: bib95 article-title: Divergent effects of hypoxia on dendritic cell functions publication-title: Blood – volume: 109 start-page: E2784 year: 2012 end-page: E2793 ident: bib24 article-title: Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa publication-title: Proc. Natl. Acad. Sci. USA – volume: 399 start-page: 271 year: 1999 end-page: 275 ident: bib97 article-title: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis publication-title: Nature – volume: 195 start-page: 1372 year: 2015 end-page: 1376 ident: bib134 article-title: Cutting Edge: hypoxia-inducible factor 1 negatively regulates Th1 function publication-title: J. Immunol. – volume: 46 start-page: 742 year: 2016 end-page: 751 ident: bib70 article-title: Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis publication-title: Eur. J. Immunol. – volume: 9 start-page: 251 year: 2018 ident: bib101 article-title: Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease publication-title: Nat. Commun. – volume: 41 start-page: 518 year: 2014 end-page: 528 ident: bib116 article-title: HIF transcription factors, inflammation, and immunity publication-title: Immunity – volume: 7 start-page: 518 year: 2016 ident: bib14 article-title: Formation of neutrophil extracellular traps under low oxygen level publication-title: Front. Immunol. – volume: 2014 start-page: 928461 year: 2014 ident: bib51 article-title: Role of Th17 cells in the pathogenesis of human IBD publication-title: ISRN Inflamm. – volume: 123 start-page: 366 year: 2014 end-page: 376 ident: bib146 article-title: Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish publication-title: Blood – volume: 209 start-page: 2441 year: 2012 end-page: 2453 ident: bib42 article-title: PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells publication-title: J. Exp. Med. – volume: 2 start-page: ra73 year: 2009 ident: bib67 article-title: Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth publication-title: Sci. Signal. – volume: 350 start-page: 17 year: 2011 end-page: 37 ident: bib75 article-title: Role of PD-1 in regulating T-cell immunity publication-title: Curr. Top. Microbiol. Immunol. – volume: 354 start-page: 481 year: 2016 end-page: 484 ident: bib119 article-title: Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism publication-title: Science – volume: 8 start-page: e68376 year: 2013 ident: bib6 article-title: HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis publication-title: PLoS One – volume: 166 start-page: 1117 year: 2016 end-page: 1131.e14 ident: bib25 article-title: Oxygen sensing by T cells establishes an immunologically tolerant metastatic niche publication-title: Cell – volume: 12 start-page: 1056 year: 2006 end-page: 1064 ident: bib124 article-title: Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis publication-title: Nat. Med. – volume: 178 start-page: 7516 year: 2007 end-page: 7519 ident: bib121 article-title: Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis publication-title: J. Immunol. – volume: 148 start-page: 399 year: 2012 end-page: 408 ident: bib130 article-title: Hypoxia-inducible factors in physiology and medicine publication-title: Cell – volume: 145 start-page: 732 year: 2011 end-page: 744 ident: bib92 article-title: Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 publication-title: Cell – volume: 167 start-page: 457 year: 2016 end-page: 470.e13 ident: bib104 article-title: Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages publication-title: Cell – volume: 7 start-page: e38489 year: 2012 ident: bib136 article-title: Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage publication-title: PLoS One – volume: 14 start-page: 1173 year: 2013 end-page: 1182 ident: bib34 article-title: Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen publication-title: Nat. Immunol. – volume: 8 start-page: 967 year: 2007 end-page: 974 ident: bib167 article-title: IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways publication-title: Nat. Immunol. – volume: 89 start-page: 503 year: 1997 end-page: 509 ident: bib53 article-title: Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase publication-title: Blood – volume: 180 start-page: 4697 year: 2008 end-page: 4705 ident: bib74 article-title: Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function publication-title: J. Immunol. – volume: 204 start-page: 1519 year: 2007 end-page: 1524 ident: bib35 article-title: CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation publication-title: J. Exp. Med. – volume: 81 start-page: 867 year: 2017 end-page: 875 ident: bib85 article-title: The role of hypoxia in angiogenesis and extracellular matrix regulation of intervertebral disc cells during inflammatory reactions publication-title: Neurosurgery – volume: 9 start-page: 327 year: 1997 end-page: 332 ident: bib112 article-title: Hypoxia response elements publication-title: Oncol. Res. – volume: 36 start-page: 295 year: 2011 end-page: 302 ident: bib63 article-title: The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells publication-title: Shock – volume: 270 start-page: 1230 year: 1995 end-page: 1237 ident: bib152 article-title: Purification and characterization of hypoxia-inducible factor 1 publication-title: J. Biol. Chem. – volume: 120 start-page: 2699 year: 2010 end-page: 2714 ident: bib73 article-title: Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation publication-title: J. Clin. Invest. – volume: 30 start-page: 4052 year: 2020 end-page: 4064.e7 ident: bib102 article-title: The absence of HIF-1α increases susceptibility to Leishmania donovani infection via activation of BNIP3/mTOR/SREBP-1c axis publication-title: Cell Rep. – volume: 303 start-page: 1532 year: 2004 end-page: 1535 ident: bib17 article-title: Neutrophil extracellular traps kill bacteria publication-title: Science – volume: 6 start-page: 265 year: 2004 end-page: 278 ident: bib66 article-title: Oxidation in rheumatoid arthritis publication-title: Arthritis Res. Ther. – volume: 22 start-page: 134 year: 2017 ident: bib40 article-title: Therapeutic potential of targeting the Th17/Treg axis in autoimmune disorders publication-title: Molecules – volume: 2 start-page: e853 year: 2007 ident: bib145 article-title: Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival publication-title: PLoS One – volume: 2013 start-page: 710239 year: 2013 ident: bib79 article-title: Flavonoids and 5-aminosalicylic acid inhibit the formation of neutrophil extracellular traps publication-title: Mediators Inflamm. – volume: 69 start-page: 43 year: 2017 end-page: 51 ident: bib94 article-title: Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism publication-title: J. Pharm. Pharmacol. – volume: 11 start-page: 1409 year: 2009 end-page: 1421 ident: bib108 article-title: The hepatitis E virus ORF3 protein stabilizes HIF-1alpha and enhances HIF-1-mediated transcriptional activity through p300/CBP publication-title: Cell. Microbiol. – volume: 197 start-page: 4034 year: 2016 end-page: 4041 ident: bib127 article-title: Myeloid cell-derived HIF-1α promotes control of Leishmania major publication-title: J. Immunol. – volume: 176 start-page: 231 year: 2007 end-page: 241 ident: bib49 article-title: Novel cell death program leads to neutrophil extracellular traps publication-title: J. Cell Biol. – volume: 47 start-page: 922 year: 2010 end-page: 931 ident: bib154 article-title: Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation publication-title: Mol. Immunol. – volume: 103 start-page: 1124 year: 2004 end-page: 1130 ident: bib11 article-title: Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha publication-title: Blood – volume: 134 start-page: 156 year: 2008 end-page: 165 ident: bib29 article-title: The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis publication-title: Gastroenterology – volume: 84 start-page: 1014 year: 2004 end-page: 1020 ident: bib3 article-title: Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes publication-title: Genomics – volume: 338 start-page: 570 year: 1991 end-page: 571 ident: bib38 article-title: Treatment of inflammatory bowel disease with anti-CD4 monoclonal antibody publication-title: Lancet – volume: 5 start-page: 577 year: 2007 end-page: 582 ident: bib16 article-title: Beneficial suicide: why neutrophils die to make NETs publication-title: Nat. Rev. Microbiol. – volume: 75 start-page: 2192 year: 2016 end-page: 2200 ident: bib10 article-title: Dysregulated bioenergetics: a key regulator of joint inflammation publication-title: Ann. Rheum. Dis. – volume: 8 start-page: e72650 year: 2013 ident: bib69 article-title: Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis publication-title: PLoS One – volume: 14 start-page: e1006874 year: 2018 ident: bib80 article-title: Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense publication-title: PLoS Pathog. – volume: 74 start-page: 665 year: 2014 end-page: 674 ident: bib8 article-title: A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells publication-title: Cancer Res. – volume: 64 start-page: 971 year: 2005 end-page: 980 ident: bib50 article-title: Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! publication-title: Ann. Rheum. Dis. – volume: 208 start-page: 1367 year: 2011 end-page: 1376 ident: bib135 article-title: HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells publication-title: J. Exp. Med. – volume: 38 start-page: 2412 year: 2008 end-page: 2418 ident: bib9 article-title: Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha publication-title: Eur. J. Immunol. – volume: 213 start-page: 733 year: 2008 end-page: 749 ident: bib12 article-title: Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration publication-title: Immunobiology – volume: 2 start-page: e116 year: 2006 ident: bib19 article-title: EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors publication-title: PLoS Pathog. – volume: 8 start-page: 3500 year: 2018 ident: bib62 article-title: HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis publication-title: Sci. Rep. – volume: 178 start-page: 2249 year: 1993 end-page: 2254 ident: bib46 article-title: An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection publication-title: J. Exp. Med. – volume: 9 start-page: 2463 year: 2018 ident: bib59 article-title: Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration publication-title: Nat. Commun. – volume: 118 start-page: 108 year: 2010 end-page: 114 ident: bib13 article-title: Hypoxia modulates phenotype, inflammatory response, and leishmanial infection of human dendritic cells publication-title: APMIS – volume: 118 start-page: 1426 year: 2013 end-page: 1436 ident: bib126 article-title: Hypoxia-inducible factor and target gene expression are decreased in patients with sepsis: prospective observational clinical and cellular studies publication-title: Anesthesiology – volume: 24 start-page: 491 year: 2010 end-page: 501 ident: bib142 article-title: Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis publication-title: Genes Dev. – volume: 71 start-page: 7433 year: 2011 end-page: 7441 ident: bib7 article-title: Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide publication-title: Cancer Res. – volume: 62 start-page: 1563 year: 2015 end-page: 1575 ident: bib88 article-title: B cells expressing CD11b effectively inhibit CD4+ T-cell responses and ameliorate experimental autoimmune hepatitis in mice publication-title: Hepatology – volume: 35 start-page: 3468 year: 2005 end-page: 3477 ident: bib164 article-title: Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells publication-title: Eur. J. Immunol. – volume: 112 start-page: 645 year: 2003 end-page: 657 ident: bib28 article-title: HIF-1alpha is essential for myeloid cell-mediated inflammation publication-title: Cell – volume: 16 start-page: 99 year: 2017 ident: bib93 article-title: Blockade of adenosine A2A receptor enhances CD8 publication-title: Mol. Cancer – volume: 2 start-page: 423 year: 2000 end-page: 427 ident: bib113 article-title: Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein publication-title: Nat. Cell Biol. – volume: 98 start-page: 707 year: 2002 end-page: 712 ident: bib141 article-title: Osteopontin induces angiogenesis of murine neuroblastoma cells in mice publication-title: Int. J. Cancer – volume: 197 start-page: 1287 year: 2016 end-page: 1297 ident: bib15 article-title: HIF-1α is an essential mediator of IFN-γ-dependent immunity to Mycobacterium tuberculosis publication-title: J. Immunol. – volume: 160 start-page: 1656 year: 1984 end-page: 1671 ident: bib61 article-title: Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme publication-title: J. Exp. Med. – volume: 146 start-page: 772 year: 2011 end-page: 784 ident: bib30 article-title: Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1 publication-title: Cell – volume: 59 start-page: 503 year: 2016 end-page: 508 ident: bib44 article-title: Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells publication-title: Mycoses – volume: 112 start-page: E957 year: 2015 end-page: E965 ident: bib87 article-title: Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1 publication-title: Proc. Natl. Acad. Sci. USA – volume: 84 start-page: 1472 year: 2008 end-page: 1482 ident: bib36 article-title: Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile publication-title: J. Leukoc. Biol. – volume: 2017 start-page: 9029327 year: 2017 ident: bib155 article-title: HIF1 publication-title: Mediators Inflamm. – volume: 114 start-page: 1098 year: 2004 end-page: 1106 ident: bib76 article-title: Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis publication-title: J. Clin. Invest. – volume: 108 start-page: 3176 year: 2006 end-page: 3178 ident: bib151 article-title: Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis publication-title: Blood – volume: 278 start-page: 39076 year: 2003 end-page: 39084 ident: bib160 article-title: Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway publication-title: J. Biol. Chem. – volume: 126 start-page: 3699 year: 2016 end-page: 3707 ident: bib26 article-title: HIF1α and metabolic reprogramming in inflammation publication-title: J. Clin. Invest. – volume: 36 start-page: e00333 year: 2016 ident: bib149 article-title: Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils publication-title: Biosci. Rep. – volume: 197 start-page: 214 year: 2008 end-page: 217 ident: bib168 article-title: Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes publication-title: J. Infect. Dis. – volume: 7 start-page: 114 year: 2014 end-page: 123 ident: bib77 article-title: Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis publication-title: Mucosal Immunol. – volume: 392 start-page: 245 year: 1998 end-page: 252 ident: bib5 article-title: Dendritic cells and the control of immunity publication-title: Nature – volume: 92 start-page: 5510 year: 1995 end-page: 5514 ident: bib153 article-title: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension publication-title: Proc. Natl. Acad. Sci. USA – volume: 10 start-page: 2711 year: 2019 ident: bib96 article-title: P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis publication-title: Nat. Commun. – volume: 25 start-page: 129 year: 2013 end-page: 137 ident: bib144 article-title: PD-1 is a novel regulator of human B-cell activation publication-title: Int. Immunol. – volume: 345 start-page: 1250684 year: 2014 ident: bib20 article-title: mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity publication-title: Science – volume: 5 start-page: e11576 year: 2010 ident: bib156 article-title: Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens publication-title: PLoS One – volume: 173 start-page: 289 year: 1983 end-page: 305 ident: bib43 article-title: Control of erythropoietin production publication-title: Proc. Soc. Exp. Biol. Med. – volume: 335 start-page: 15 year: 2019 end-page: 21 ident: bib2 article-title: HIF-1α-regulated MIF activation and Nox2-dependent ROS generation promote Leishmania amazonensis killing by macrophages under hypoxia publication-title: Cell. Immunol. – volume: 194 start-page: 3389 year: 2015 end-page: 3399 ident: bib55 article-title: Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration publication-title: J. Immunol. – volume: 25 start-page: 1865 year: 2019 end-page: 1878 ident: bib166 article-title: Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation publication-title: World J. Gastroenterol. – volume: 93 start-page: 266 year: 2001 end-page: 276 ident: bib68 article-title: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects publication-title: J. Natl. Cancer Inst. – volume: 6 start-page: e39 year: 2017 ident: bib60 article-title: Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines publication-title: Emerg. Microbes Infect. – volume: 32 start-page: 669 year: 2017 end-page: 683.e5 ident: bib117 article-title: An HIF-1α/VEGF-A axis in cytotoxic T cells regulates tumor progression publication-title: Cancer Cell – volume: 18 start-page: 433 year: 2015 end-page: 448 ident: bib37 article-title: The pathogenic role of angiogenesis in rheumatoid arthritis publication-title: Angiogenesis – volume: 19 start-page: 1330 year: 2020 end-page: 1342 ident: bib71 article-title: Downregulation of hypoxia-inducible factor-1α by RNA interference alleviates the development of collagen-induced arthritis in rats publication-title: Mol. Ther. Nucleic Acids – volume: 12 start-page: 5447 year: 1992 end-page: 5454 ident: bib131 article-title: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation publication-title: Mol. Cell. Biol. – volume: 42 start-page: 1226 year: 2012 end-page: 1236 ident: bib81 article-title: Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration publication-title: Eur. J. Immunol. – volume: 216 start-page: 832 year: 2011 end-page: 839 ident: bib138 article-title: Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA publication-title: Immunobiology – volume: 179 start-page: 4313 year: 2007 end-page: 4317 ident: bib65 article-title: Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity publication-title: J. Immunol. – volume: 496 start-page: 238 year: 2013 end-page: 242 ident: bib143 article-title: Succinate is an inflammatory signal that induces IL-1β through HIF-1α publication-title: Nature – volume: 184 start-page: 154 year: 2010 end-page: 163 ident: bib83 article-title: Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow publication-title: J. Immunol. – volume: 36 start-page: 510 year: 2011 end-page: 516 ident: bib158 article-title: Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide publication-title: Shock – volume: 116 start-page: 8975 year: 2019 end-page: 8984 ident: bib22 article-title: Hypoxia-inducible factors in CD4 publication-title: Proc. Natl. Acad. Sci. USA – volume: 145 start-page: 402 year: 2020 end-page: 414 ident: bib140 article-title: Particulate matter of 2.5 μm or less in diameter disturbs the balance of T publication-title: J. Allergy Clin. Immunol. – volume: 122 start-page: 2784 year: 2013 end-page: 2794 ident: bib159 article-title: NETosis: how vital is it? publication-title: Blood – volume: 26 start-page: 225 year: 2007 end-page: 239 ident: bib148 article-title: Hypoxia in cancer: significance and impact on clinical outcome publication-title: Cancer Metastasis Rev. – volume: 10 start-page: 2333 year: 2014 end-page: 2345 ident: bib107 article-title: HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC) publication-title: Autophagy – volume: 201 start-page: 105 year: 2005 end-page: 115 ident: bib150 article-title: Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity publication-title: J. Exp. Med. – volume: 21 start-page: 1209 year: 2015 end-page: 1215 ident: bib89 article-title: CD47 blockade triggers T cell-mediated destruction of immunogenic tumors publication-title: Nat. Med. – volume: 227 start-page: 587 year: 2012 end-page: 595 ident: bib110 article-title: Hypoxia affects dendritic cell survival: role of the hypoxia-inducible factor-1α and lipopolysaccharide publication-title: J. Cell. Physiol. – volume: 229 start-page: 2067 year: 2014 end-page: 2076 ident: bib41 article-title: Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α and PI3K/Akt pathway publication-title: J. Cell. Physiol. – volume: 379 start-page: 88 year: 1996 end-page: 91 ident: bib57 article-title: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours publication-title: Nature – volume: 21 start-page: 347 year: 2015 ident: bib118 article-title: Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the Warburg effect in LPS-activated macrophages publication-title: Cell Metab. – volume: 7 start-page: 77 year: 2005 end-page: 85 ident: bib128 article-title: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase publication-title: Cancer Cell – volume: 308 start-page: 179 year: 2006 end-page: 191 ident: bib56 article-title: Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression publication-title: J. Immunol. Methods – volume: 195 start-page: 1 year: 2003 end-page: 16 ident: bib39 article-title: Prognostic significance of tumor oxygenation in humans publication-title: Cancer Lett. – volume: 4 start-page: 2813 year: 2013 ident: bib33 article-title: Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance publication-title: Nat. Commun. – volume: 69 start-page: 5082 year: 2009 end-page: 5090 ident: bib162 article-title: Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma publication-title: Cancer Res. – volume: 13 start-page: 769 year: 1970 end-page: 776 ident: bib91 article-title: Oxygen tension in synovial fluids publication-title: Arthritis Rheum. – volume: 2 start-page: 335 year: 2011 end-page: 346 ident: bib106 article-title: Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses publication-title: Gut Microbes – volume: 350 start-page: 307 year: 2000 end-page: 312 ident: bib147 article-title: Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts publication-title: Biochem. J. – volume: 27 start-page: 945 year: 2009 end-page: 951 ident: bib18 article-title: Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis publication-title: Clin. Exp. Rheumatol. – volume: 99 start-page: 2170 year: 2002 end-page: 2174 ident: bib82 article-title: Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice publication-title: Proc. Natl. Acad. Sci. USA – volume: 9 start-page: 327 year: 1997 ident: 10.1016/j.cmet.2020.08.002_bib112 article-title: Hypoxia response elements publication-title: Oncol. Res. – volume: 197 start-page: 4034 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib127 article-title: Myeloid cell-derived HIF-1α promotes control of Leishmania major publication-title: J. Immunol. doi: 10.4049/jimmunol.1601080 – volume: 10 start-page: 2333 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib107 article-title: HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC) publication-title: Autophagy doi: 10.4161/15548627.2014.984275 – volume: 32 start-page: 669 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib117 article-title: An HIF-1α/VEGF-A axis in cytotoxic T cells regulates tumor progression publication-title: Cancer Cell doi: 10.1016/j.ccell.2017.10.003 – volume: 6 start-page: 265 year: 2004 ident: 10.1016/j.cmet.2020.08.002_bib66 article-title: Oxidation in rheumatoid arthritis publication-title: Arthritis Res. Ther. doi: 10.1186/ar1447 – volume: 148 start-page: 399 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib130 article-title: Hypoxia-inducible factors in physiology and medicine publication-title: Cell doi: 10.1016/j.cell.2012.01.021 – volume: 350 start-page: 17 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib75 article-title: Role of PD-1 in regulating T-cell immunity publication-title: Curr. Top. Microbiol. Immunol. – volume: 338 start-page: 570 year: 1991 ident: 10.1016/j.cmet.2020.08.002_bib38 article-title: Treatment of inflammatory bowel disease with anti-CD4 monoclonal antibody publication-title: Lancet doi: 10.1016/0140-6736(91)91133-F – volume: 12 start-page: 1056 year: 2006 ident: 10.1016/j.cmet.2020.08.002_bib124 article-title: Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis publication-title: Nat. Med. doi: 10.1038/nm1468 – volume: 47 start-page: 922 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib154 article-title: Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2009.09.038 – volume: 30 start-page: 4052 year: 2020 ident: 10.1016/j.cmet.2020.08.002_bib102 article-title: The absence of HIF-1α increases susceptibility to Leishmania donovani infection via activation of BNIP3/mTOR/SREBP-1c axis publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.02.098 – volume: 166 start-page: 1117 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib25 article-title: Oxygen sensing by T cells establishes an immunologically tolerant metastatic niche publication-title: Cell doi: 10.1016/j.cell.2016.07.032 – volume: 2014 start-page: 928461 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib51 article-title: Role of Th17 cells in the pathogenesis of human IBD publication-title: ISRN Inflamm. doi: 10.1155/2014/928461 – volume: 184 start-page: 154 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib83 article-title: Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow publication-title: J. Immunol. doi: 10.4049/jimmunol.0800167 – volume: 197 start-page: 4014 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib1 article-title: Germinal center hypoxia potentiates immunoglobulin class switch recombination publication-title: J. Immunol. doi: 10.4049/jimmunol.1601401 – volume: 7 start-page: 184 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib72 article-title: Hypoxia-inducible factor (HIF) as a target for novel therapies in rheumatoid arthritis publication-title: Front. Pharmacol. doi: 10.3389/fphar.2016.00184 – volume: 14 start-page: e1006874 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib80 article-title: Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1006874 – volume: 345 start-page: 1250684 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib20 article-title: mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity publication-title: Science doi: 10.1126/science.1250684 – volume: 62 start-page: 1563 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib88 article-title: B cells expressing CD11b effectively inhibit CD4+ T-cell responses and ameliorate experimental autoimmune hepatitis in mice publication-title: Hepatology doi: 10.1002/hep.28001 – volume: 167 start-page: 457 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib104 article-title: Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages publication-title: Cell doi: 10.1016/j.cell.2016.08.064 – volume: 112 start-page: 645 year: 2003 ident: 10.1016/j.cmet.2020.08.002_bib28 article-title: HIF-1alpha is essential for myeloid cell-mediated inflammation publication-title: Cell doi: 10.1016/S0092-8674(03)00154-5 – volume: 112 start-page: 3723 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib95 article-title: Divergent effects of hypoxia on dendritic cell functions publication-title: Blood doi: 10.1182/blood-2008-02-142091 – volume: 89 start-page: 503 year: 1997 ident: 10.1016/j.cmet.2020.08.002_bib53 article-title: Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase publication-title: Blood doi: 10.1182/blood.V89.2.503 – volume: 278 start-page: 39076 year: 2003 ident: 10.1016/j.cmet.2020.08.002_bib160 article-title: Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway publication-title: J. Biol. Chem. doi: 10.1074/jbc.M305101200 – volume: 10 start-page: 2711 year: 2019 ident: 10.1016/j.cmet.2020.08.002_bib96 article-title: P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis publication-title: Nat. Commun. doi: 10.1038/s41467-019-10626-x – volume: 7 start-page: 77 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib128 article-title: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase publication-title: Cancer Cell doi: 10.1016/j.ccr.2004.11.022 – volume: 42 start-page: 484 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib133 article-title: Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α publication-title: Immunity doi: 10.1016/j.immuni.2015.02.001 – volume: 496 start-page: 238 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib143 article-title: Succinate is an inflammatory signal that induces IL-1β through HIF-1α publication-title: Nature doi: 10.1038/nature11986 – volume: 4 start-page: 2813 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib33 article-title: Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance publication-title: Nat. Commun. doi: 10.1038/ncomms3813 – volume: 21 start-page: 1209 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib89 article-title: CD47 blockade triggers T cell-mediated destruction of immunogenic tumors publication-title: Nat. Med. doi: 10.1038/nm.3931 – volume: 8 start-page: e72650 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib69 article-title: Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis publication-title: PLoS One doi: 10.1371/journal.pone.0072650 – volume: 36 start-page: 295 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib63 article-title: The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells publication-title: Shock doi: 10.1097/SHK.0b013e318225ad7e – volume: 197 start-page: 214 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib168 article-title: Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes publication-title: J. Infect. Dis. doi: 10.1086/524843 – volume: 84 start-page: 1472 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib36 article-title: Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0208082 – volume: 118 start-page: 1426 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib126 article-title: Hypoxia-inducible factor and target gene expression are decreased in patients with sepsis: prospective observational clinical and cellular studies publication-title: Anesthesiology doi: 10.1097/ALN.0b013e31828baa67 – volume: 123 start-page: 366 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib146 article-title: Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish publication-title: Blood doi: 10.1182/blood-2013-05-500207 – volume: 7 start-page: e38489 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib136 article-title: Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage publication-title: PLoS One doi: 10.1371/journal.pone.0038489 – volume: 208 start-page: 1367 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib135 article-title: HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells publication-title: J. Exp. Med. doi: 10.1084/jem.20110278 – volume: 8 start-page: 3500 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib62 article-title: HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis publication-title: Sci. Rep. doi: 10.1038/s41598-018-21891-z – volume: 46 start-page: 742 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib70 article-title: Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis publication-title: Eur. J. Immunol. doi: 10.1002/eji.201545784 – volume: 5 start-page: e11576 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib156 article-title: Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens publication-title: PLoS One doi: 10.1371/journal.pone.0011576 – volume: 69 start-page: 43 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib94 article-title: Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism publication-title: J. Pharm. Pharmacol. doi: 10.1111/jphp.12655 – volume: 196 start-page: 2444 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib54 article-title: Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication publication-title: J. Immunol. doi: 10.4049/jimmunol.1501612 – volume: 9 start-page: 2463 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib59 article-title: Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration publication-title: Nat. Commun. doi: 10.1038/s41467-018-04804-6 – volume: 8 start-page: 967 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib167 article-title: IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways publication-title: Nat. Immunol. doi: 10.1038/ni1488 – volume: 270 start-page: 1230 year: 1995 ident: 10.1016/j.cmet.2020.08.002_bib152 article-title: Purification and characterization of hypoxia-inducible factor 1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.3.1230 – volume: 36 start-page: e00333 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib149 article-title: Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils publication-title: Biosci. Rep. doi: 10.1042/BSR20160031 – volume: 21 start-page: 347 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib118 article-title: Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the Warburg effect in LPS-activated macrophages publication-title: Cell Metab. doi: 10.1016/j.cmet.2015.01.017 – volume: 178 start-page: 2249 year: 1993 ident: 10.1016/j.cmet.2020.08.002_bib46 article-title: An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection publication-title: J. Exp. Med. doi: 10.1084/jem.178.6.2249 – volume: 2 start-page: 423 year: 2000 ident: 10.1016/j.cmet.2020.08.002_bib113 article-title: Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein publication-title: Nat. Cell Biol. doi: 10.1038/35017054 – volume: 45 start-page: 2187 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib165 article-title: Hypoxia suppresses the production of MMP-9 by human monocyte-derived dendritic cells and requires activation of adenosine receptor A2b via cAMP/PKA signaling pathway publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2007.12.002 – volume: 303 start-page: 1532 year: 2004 ident: 10.1016/j.cmet.2020.08.002_bib17 article-title: Neutrophil extracellular traps kill bacteria publication-title: Science doi: 10.1126/science.1092385 – volume: 145 start-page: 402 year: 2020 ident: 10.1016/j.cmet.2020.08.002_bib140 article-title: Particulate matter of 2.5 μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1α in an asthma model publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2019.10.008 – volume: 16 start-page: 99 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib93 article-title: Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma publication-title: Mol. Cancer doi: 10.1186/s12943-017-0665-0 – volume: 120 start-page: 3118 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib99 article-title: Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α publication-title: Blood doi: 10.1182/blood-2012-01-405993 – volume: 211 start-page: 781 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib111 article-title: PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation publication-title: J. Exp. Med. doi: 10.1084/jem.20131916 – volume: 227 start-page: 587 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib110 article-title: Hypoxia affects dendritic cell survival: role of the hypoxia-inducible factor-1α and lipopolysaccharide publication-title: J. Cell. Physiol. doi: 10.1002/jcp.22761 – volume: 35 start-page: 3468 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib164 article-title: Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells publication-title: Eur. J. Immunol. doi: 10.1002/eji.200526262 – volume: 92 start-page: 5510 year: 1995 ident: 10.1016/j.cmet.2020.08.002_bib153 article-title: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.92.12.5510 – volume: 69 start-page: 5082 year: 2009 ident: 10.1016/j.cmet.2020.08.002_bib162 article-title: Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-4603 – volume: 335 start-page: 15 year: 2019 ident: 10.1016/j.cmet.2020.08.002_bib2 article-title: HIF-1α-regulated MIF activation and Nox2-dependent ROS generation promote Leishmania amazonensis killing by macrophages under hypoxia publication-title: Cell. Immunol. doi: 10.1016/j.cellimm.2018.10.007 – volume: 116 start-page: 8975 year: 2019 ident: 10.1016/j.cmet.2020.08.002_bib22 article-title: Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1811702116 – volume: 179 start-page: 4313 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib65 article-title: Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity publication-title: J. Immunol. doi: 10.4049/jimmunol.179.7.4313 – volume: 178 start-page: 7516 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib121 article-title: Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis publication-title: J. Immunol. doi: 10.4049/jimmunol.178.12.7516 – volume: 195 start-page: 1372 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib134 article-title: Cutting Edge: hypoxia-inducible factor 1 negatively regulates Th1 function publication-title: J. Immunol. doi: 10.4049/jimmunol.1402552 – volume: 229 start-page: 2067 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib41 article-title: Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α and PI3K/Akt pathway publication-title: J. Cell. Physiol. doi: 10.1002/jcp.24666 – volume: 19 start-page: 1330 year: 2020 ident: 10.1016/j.cmet.2020.08.002_bib71 article-title: Downregulation of hypoxia-inducible factor-1α by RNA interference alleviates the development of collagen-induced arthritis in rats publication-title: Mol. Ther. Nucleic Acids doi: 10.1016/j.omtn.2020.01.014 – volume: 7 start-page: 114 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib77 article-title: Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis publication-title: Mucosal Immunol. doi: 10.1038/mi.2013.29 – volume: 204 start-page: 1519 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib35 article-title: CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation publication-title: J. Exp. Med. doi: 10.1084/jem.20062292 – volume: 38 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib115 article-title: Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8 publication-title: Biosci. Rep. doi: 10.1042/BSR20182019 – volume: 173 start-page: 289 year: 1983 ident: 10.1016/j.cmet.2020.08.002_bib43 article-title: Control of erythropoietin production publication-title: Proc. Soc. Exp. Biol. Med. doi: 10.3181/00379727-173-41646 – volume: 112 start-page: E957 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib87 article-title: Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1420419112 – volume: 8 start-page: e68376 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib6 article-title: HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis publication-title: PLoS One doi: 10.1371/journal.pone.0068376 – volume: 98 start-page: 707 year: 2002 ident: 10.1016/j.cmet.2020.08.002_bib141 article-title: Osteopontin induces angiogenesis of murine neuroblastoma cells in mice publication-title: Int. J. Cancer doi: 10.1002/ijc.10261 – volume: 38 start-page: 2412 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib9 article-title: Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha publication-title: Eur. J. Immunol. doi: 10.1002/eji.200838318 – volume: 56 start-page: 209 year: 2003 ident: 10.1016/j.cmet.2020.08.002_bib52 article-title: Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease publication-title: J. Clin. Pathol. doi: 10.1136/jcp.56.3.209 – volume: 94 start-page: 122 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib157 article-title: HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn’s disease publication-title: J. Autoimmun. doi: 10.1016/j.jaut.2018.07.022 – volume: 8 start-page: S62 issue: Suppl year: 2002 ident: 10.1016/j.cmet.2020.08.002_bib129 article-title: HIF-1 and tumor progression: pathophysiology and therapeutics publication-title: Trends Mol. Med. doi: 10.1016/S1471-4914(02)02317-1 – volume: 75 start-page: 2192 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib10 article-title: Dysregulated bioenergetics: a key regulator of joint inflammation publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2015-208476 – volume: 160 start-page: 1656 year: 1984 ident: 10.1016/j.cmet.2020.08.002_bib61 article-title: Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme publication-title: J. Exp. Med. doi: 10.1084/jem.160.6.1656 – volume: 180 start-page: 4697 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib74 article-title: Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function publication-title: J. Immunol. doi: 10.4049/jimmunol.180.7.4697 – volume: 2 start-page: ra73 year: 2009 ident: 10.1016/j.cmet.2020.08.002_bib67 article-title: Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth publication-title: Sci. Signal. doi: 10.1126/scisignal.2000431 – volume: 25 start-page: 129 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib144 article-title: PD-1 is a novel regulator of human B-cell activation publication-title: Int. Immunol. doi: 10.1093/intimm/dxs098 – volume: 2 start-page: e853 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib145 article-title: Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival publication-title: PLoS One doi: 10.1371/journal.pone.0000853 – volume: 81 start-page: 867 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib85 article-title: The role of hypoxia in angiogenesis and extracellular matrix regulation of intervertebral disc cells during inflammatory reactions publication-title: Neurosurgery doi: 10.1093/neuros/nyx149 – volume: 93 start-page: 266 year: 2001 ident: 10.1016/j.cmet.2020.08.002_bib68 article-title: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/93.4.266 – volume: 27 start-page: 945 year: 2009 ident: 10.1016/j.cmet.2020.08.002_bib18 article-title: Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis publication-title: Clin. Exp. Rheumatol. – volume: 201 start-page: 105 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib150 article-title: Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity publication-title: J. Exp. Med. doi: 10.1084/jem.20040624 – volume: 350 start-page: 307 year: 2000 ident: 10.1016/j.cmet.2020.08.002_bib147 article-title: Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts publication-title: Biochem. J. doi: 10.1042/bj3500307 – volume: 396 start-page: 517 year: 2006 ident: 10.1016/j.cmet.2020.08.002_bib47 article-title: Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB publication-title: Biochem. J. doi: 10.1042/BJ20051839 – volume: 120 start-page: 2699 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib73 article-title: Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation publication-title: J. Clin. Invest. doi: 10.1172/JCI39506 – volume: 379 start-page: 88 year: 1996 ident: 10.1016/j.cmet.2020.08.002_bib57 article-title: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours publication-title: Nature doi: 10.1038/379088a0 – volume: 399 start-page: 271 year: 1999 ident: 10.1016/j.cmet.2020.08.002_bib97 article-title: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis publication-title: Nature doi: 10.1038/20459 – volume: 7 start-page: 518 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib14 article-title: Formation of neutrophil extracellular traps under low oxygen level publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00518 – volume: 18 start-page: 433 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib37 article-title: The pathogenic role of angiogenesis in rheumatoid arthritis publication-title: Angiogenesis doi: 10.1007/s10456-015-9477-2 – volume: 41 start-page: 518 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib116 article-title: HIF transcription factors, inflammation, and immunity publication-title: Immunity doi: 10.1016/j.immuni.2014.09.008 – volume: 2012 start-page: 849136 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib78 article-title: The impact of various reactive oxygen species on the formation of neutrophil extracellular traps publication-title: Mediators Inflamm. doi: 10.1155/2012/849136 – volume: 12 start-page: 5447 year: 1992 ident: 10.1016/j.cmet.2020.08.002_bib131 article-title: A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation publication-title: Mol. Cell. Biol. – volume: 2 start-page: 335 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib106 article-title: Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses publication-title: Gut Microbes doi: 10.4161/gmic.18771 – volume: 35 start-page: e90 year: 2020 ident: 10.1016/j.cmet.2020.08.002_bib64 article-title: Effects of hyperbaric oxygen on T helper 17/regulatory T polarization in antigen and collagen-induced arthritis: hypoxia-inducible factor-1α as a target publication-title: Oman Med. J. doi: 10.5001/omj.2020.08 – volume: 109 start-page: E2784 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib24 article-title: Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1202366109 – volume: 36 start-page: 510 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib158 article-title: Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide publication-title: Shock doi: 10.1097/SHK.0b013e318231866f – volume: 114 start-page: 1098 year: 2004 ident: 10.1016/j.cmet.2020.08.002_bib76 article-title: Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis publication-title: J. Clin. Invest. doi: 10.1172/JCI200421086 – volume: 24 start-page: 491 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib142 article-title: Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis publication-title: Genes Dev. doi: 10.1101/gad.1881410 – volume: 15 start-page: 300 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib98 article-title: Pyruvate kinase type M2 and its role in tumor growth and spreading publication-title: Semin. Cancer Biol. doi: 10.1016/j.semcancer.2005.04.009 – volume: 13 start-page: 785 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib4 article-title: Dual role of hypoxia-inducible factor 1 α in experimental pulmonary tuberculosis: its implication as a new therapeutic target publication-title: Future Microbiol. doi: 10.2217/fmb-2017-0168 – volume: 537 start-page: 234 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib21 article-title: Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system publication-title: Nature doi: 10.1038/nature19334 – volume: 94 start-page: 237 year: 1957 ident: 10.1016/j.cmet.2020.08.002_bib48 article-title: Studies on erythropoiesis. III. Factors controlling erythropoietin production publication-title: Proc. Soc. Exp. Biol. Med. doi: 10.3181/00379727-94-22910 – volume: 115 start-page: 1806 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib120 article-title: HIF-1alpha expression regulates the bactericidal capacity of phagocytes publication-title: J. Clin. Invest. doi: 10.1172/JCI23865 – volume: 8 start-page: 153 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib84 article-title: Hypoxia--a key regulator of angiogenesis and inflammation in rheumatoid arthritis publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2011.205 – volume: 9 start-page: 379 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib45 article-title: Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis publication-title: Mucosal Immunol. doi: 10.1038/mi.2015.67 – volume: 2013 start-page: 710239 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib79 article-title: Flavonoids and 5-aminosalicylic acid inhibit the formation of neutrophil extracellular traps publication-title: Mediators Inflamm. doi: 10.1155/2013/710239 – volume: 354 start-page: 481 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib119 article-title: Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism publication-title: Science doi: 10.1126/science.aaf6284 – volume: 100 start-page: 3008 year: 2002 ident: 10.1016/j.cmet.2020.08.002_bib100 article-title: Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis publication-title: Blood doi: 10.1182/blood-2002-02-0454 – volume: 42 start-page: 1226 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib81 article-title: Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration publication-title: Eur. J. Immunol. doi: 10.1002/eji.201142053 – volume: 108 start-page: 3176 year: 2006 ident: 10.1016/j.cmet.2020.08.002_bib151 article-title: Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis publication-title: Blood doi: 10.1182/blood-2006-04-018796 – volume: 13 start-page: 769 year: 1970 ident: 10.1016/j.cmet.2020.08.002_bib91 article-title: Oxygen tension in synovial fluids publication-title: Arthritis Rheum. doi: 10.1002/art.1780130606 – volume: 186 start-page: 3299 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib103 article-title: Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets publication-title: J. Immunol. doi: 10.4049/jimmunol.1003613 – volume: 122 start-page: 2784 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib159 article-title: NETosis: how vital is it? publication-title: Blood doi: 10.1182/blood-2013-04-457671 – volume: 213 start-page: 733 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib12 article-title: Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration publication-title: Immunobiology doi: 10.1016/j.imbio.2008.07.031 – volume: 42 start-page: 1062 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib86 article-title: E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1α to maintain regulatory T cell stability and suppressive capacity publication-title: Immunity doi: 10.1016/j.immuni.2015.05.016 – volume: 59 start-page: 503 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib44 article-title: Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells publication-title: Mycoses doi: 10.1111/myc.12498 – volume: 195 start-page: 1 year: 2003 ident: 10.1016/j.cmet.2020.08.002_bib39 article-title: Prognostic significance of tumor oxygenation in humans publication-title: Cancer Lett. doi: 10.1016/S0304-3835(03)00012-0 – volume: 112 start-page: E6215 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib163 article-title: HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1520032112 – volume: 284 start-page: 11364 year: 2009 ident: 10.1016/j.cmet.2020.08.002_bib32 article-title: Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression publication-title: J. Biol. Chem. doi: 10.1074/jbc.M809266200 – volume: 111 start-page: 5571 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib109 article-title: HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak publication-title: Blood doi: 10.1182/blood-2007-11-126763 – volume: 194 start-page: 3389 year: 2015 ident: 10.1016/j.cmet.2020.08.002_bib55 article-title: Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration publication-title: J. Immunol. doi: 10.4049/jimmunol.1401420 – volume: 40 start-page: 320 year: 1997 ident: 10.1016/j.cmet.2020.08.002_bib139 article-title: CD4 antibody treatment in patients with active Crohn’s disease: a phase 1 dose finding study publication-title: Gut doi: 10.1136/gut.40.3.320 – volume: 134 start-page: 156 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib29 article-title: The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.10.012 – volume: 26 start-page: 225 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib148 article-title: Hypoxia in cancer: significance and impact on clinical outcome publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-007-9055-1 – volume: 22 start-page: 134 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib40 article-title: Therapeutic potential of targeting the Th17/Treg axis in autoimmune disorders publication-title: Molecules doi: 10.3390/molecules22010134 – volume: 145 start-page: 732 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib92 article-title: Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 publication-title: Cell doi: 10.1016/j.cell.2011.03.054 – volume: 114 start-page: 119 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib31 article-title: Expression of hypoxia-inducible factor 1alpha in mononuclear phagocytes infected with Leishmania amazonensis publication-title: Immunol. Lett. doi: 10.1016/j.imlet.2007.09.009 – volume: 14 start-page: 1173 year: 2013 ident: 10.1016/j.cmet.2020.08.002_bib34 article-title: Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen publication-title: Nat. Immunol. doi: 10.1038/ni.2714 – volume: 71 start-page: 7433 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib7 article-title: Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-11-2104 – volume: 452 start-page: 230 year: 2008 ident: 10.1016/j.cmet.2020.08.002_bib23 article-title: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth publication-title: Nature doi: 10.1038/nature06734 – volume: 111 start-page: 162 year: 2019 ident: 10.1016/j.cmet.2020.08.002_bib122 article-title: Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2019.04.005 – volume: 146 start-page: 772 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib30 article-title: Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1 publication-title: Cell doi: 10.1016/j.cell.2011.07.033 – volume: 84 start-page: 1014 year: 2004 ident: 10.1016/j.cmet.2020.08.002_bib3 article-title: Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes publication-title: Genomics doi: 10.1016/j.ygeno.2004.08.010 – volume: 88 start-page: 5680 year: 1991 ident: 10.1016/j.cmet.2020.08.002_bib132 article-title: Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.88.13.5680 – volume: 64 start-page: 971 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib50 article-title: Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! publication-title: Ann. Rheum. Dis. doi: 10.1136/ard.2004.031641 – volume: 556 start-page: 113 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib105 article-title: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 publication-title: Nature doi: 10.1038/nature25986 – volume: 83 start-page: 668 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib123 article-title: Hypoxia inhibits the migratory capacity of human monocyte-derived dendritic cells publication-title: Immunol. Cell Biol. doi: 10.1111/j.1440-1711.2005.01383.x – volume: 209 start-page: 2441 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib42 article-title: PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells publication-title: J. Exp. Med. doi: 10.1084/jem.20112607 – volume: 206 start-page: 291 year: 2005 ident: 10.1016/j.cmet.2020.08.002_bib58 article-title: Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1) publication-title: J. Pathol. doi: 10.1002/path.1778 – volume: 216 start-page: 832 year: 2011 ident: 10.1016/j.cmet.2020.08.002_bib138 article-title: Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA publication-title: Immunobiology doi: 10.1016/j.imbio.2010.12.005 – volume: 118 start-page: 108 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib13 article-title: Hypoxia modulates phenotype, inflammatory response, and leishmanial infection of human dendritic cells publication-title: APMIS doi: 10.1111/j.1600-0463.2009.02568.x – volume: 207 start-page: 2439 year: 2010 ident: 10.1016/j.cmet.2020.08.002_bib27 article-title: HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment publication-title: J. Exp. Med. doi: 10.1084/jem.20100587 – volume: 103 start-page: 1124 year: 2004 ident: 10.1016/j.cmet.2020.08.002_bib11 article-title: Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha publication-title: Blood doi: 10.1182/blood-2003-07-2427 – volume: 9 start-page: 251 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib101 article-title: Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease publication-title: Nat. Commun. doi: 10.1038/s41467-017-02683-x – volume: 25 start-page: 1865 year: 2019 ident: 10.1016/j.cmet.2020.08.002_bib166 article-title: Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v25.i15.1865 – volume: 6 start-page: e39 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib60 article-title: Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines publication-title: Emerg. Microbes Infect. doi: 10.1038/emi.2017.21 – volume: 74 start-page: 6771 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib137 article-title: CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0037-T – volume: 24 start-page: 55 year: 2018 ident: 10.1016/j.cmet.2020.08.002_bib161 article-title: Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis publication-title: Mol. Med. doi: 10.1186/s10020-018-0053-2 – volume: 5 start-page: 577 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib16 article-title: Beneficial suicide: why neutrophils die to make NETs publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro1710 – volume: 234 start-page: 1355 year: 1959 ident: 10.1016/j.cmet.2020.08.002_bib125 article-title: The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)70011-2 – volume: 74 start-page: 665 year: 2014 ident: 10.1016/j.cmet.2020.08.002_bib8 article-title: A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-13-0992 – volume: 99 start-page: 2170 year: 2002 ident: 10.1016/j.cmet.2020.08.002_bib82 article-title: Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.052706699 – volume: 90 start-page: 1079 year: 2012 ident: 10.1016/j.cmet.2020.08.002_bib114 article-title: A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection publication-title: J. Mol. Med. (Berl.) doi: 10.1007/s00109-012-0882-3 – volume: 2 start-page: e116 year: 2006 ident: 10.1016/j.cmet.2020.08.002_bib19 article-title: EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.0020116 – volume: 2017 start-page: 9029327 year: 2017 ident: 10.1016/j.cmet.2020.08.002_bib155 article-title: HIF1α-induced glycolysis metabolism is essential to the activation of inflammatory macrophages publication-title: Mediators Inflamm. doi: 10.1155/2017/9029327 – volume: 392 start-page: 245 year: 1998 ident: 10.1016/j.cmet.2020.08.002_bib5 article-title: Dendritic cells and the control of immunity publication-title: Nature doi: 10.1038/32588 – volume: 126 start-page: 3699 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib26 article-title: HIF1α and metabolic reprogramming in inflammation publication-title: J. Clin. Invest. doi: 10.1172/JCI84431 – volume: 176 start-page: 231 year: 2007 ident: 10.1016/j.cmet.2020.08.002_bib49 article-title: Novel cell death program leads to neutrophil extracellular traps publication-title: J. Cell Biol. doi: 10.1083/jcb.200606027 – volume: 50 start-page: 600 year: 2019 ident: 10.1016/j.cmet.2020.08.002_bib90 article-title: CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1α-mediated glycolysis publication-title: Immunity doi: 10.1016/j.immuni.2019.01.021 – volume: 11 start-page: 1409 year: 2009 ident: 10.1016/j.cmet.2020.08.002_bib108 article-title: The hepatitis E virus ORF3 protein stabilizes HIF-1alpha and enhances HIF-1-mediated transcriptional activity through p300/CBP publication-title: Cell. Microbiol. doi: 10.1111/j.1462-5822.2009.01340.x – volume: 197 start-page: 1287 year: 2016 ident: 10.1016/j.cmet.2020.08.002_bib15 article-title: HIF-1α is an essential mediator of IFN-γ-dependent immunity to Mycobacterium tuberculosis publication-title: J. Immunol. doi: 10.4049/jimmunol.1600266 – volume: 308 start-page: 179 year: 2006 ident: 10.1016/j.cmet.2020.08.002_bib56 article-title: Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression publication-title: J. Immunol. Methods doi: 10.1016/j.jim.2005.10.012 |
| SSID | ssj0036393 |
| Score | 2.7097483 |
| SecondaryResourceType | review_article |
| Snippet | HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 524 |
| Title | The Role of HIF in Immunity and Inflammation |
| URI | https://dx.doi.org/10.1016/j.cmet.2020.08.002 https://www.ncbi.nlm.nih.gov/pubmed/32853548 https://www.proquest.com/docview/2438676593 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwEA8iCL6I384vIvimdWuTpu2jimMT9EEd7C0k1ytMZje0Pvjfe2nagQ_bg48tF3Lc5b7I73KMXcaYhJBHEKSQYCANQGBRqgCtkVaYXGHdSPv0rAYj-TiOx2vsvu2FcbDKxvd7n1576-ZPt5Fmdz6ZdF9dck0uOIzc7Z6v24VM6ya-8V3rjQVF4BpkT8SBo24aZzzGCz7Q4Smj3o2HVC4LTsuSzzoI9bfZVpM98lvP4A5bw3KXbfh5kj977JqUzl9mU-Szgg-GfT4p-bBuAKl-uClzPiwLOgG-W3GfjfoPb_eDoBmHEIBUqgpiaxOZk4nGOUXllKJblmGkiljkCiCxiUnJXCkq9VCFppAoIbVJVgCGBtyzfAdsvZyVeMR4lqahAhQGcitjpJykB1aJME8KoBpHdFjYykFD81a4G1kx1S0o7F072WknO-3mWPaiDrtarJn7lzJWUsetePUffWty5SvXXbS60GQI7nbDlDj7_tKRFKlKVJwR94deSQs-RERZCdVmx__c9YRtuq8axKdO2Xr1-Y1nlIxU9rw-bb8CxtnX |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VVoheEOXRlkIxEpwg7MZx7OTAAQqrDX0coJX2ZuzJRNpqm63arar9XfxBxnlU4tAekHpN4mT0eTLzWf7GA_AuJRNjKTHK0FCkHGLkSemIvFM-caWmppD28EiPT9SPSTpZgT99LUyQVXaxv43pTbTurgw6NAfn0-ngVyDXHIJjGXb3mNd0ysp9Wl7zuu3yc_GNJ_m9lKPvx3vjqGstEKHSehGl3htVsrunJWe4jDNFnpPUVZqUGtF44zJ2fY7wQ9KxqxQpzLzJK6TYYTjijt_7ANaYfZgQDYrJ1z78J5zyG1U_WxcF87pKnVZUhmcUBJxy-KnVcN6WDW9ju03WGz2Bxx1dFV9aRDZgheqn8LBtYLl8Bh_Zy8TP-YzEvBLjYiSmtSiaipPFUri6FEVdscu15ZHP4eReQHoBq_W8pi0QeZbFGilxWHqVEpOgIXqdxKWpkBdVyTbEPQ4Wu8PJQ4-Mme1VaKc2YGcDdjY0zhzKbfhwM-a8PZrjzqfTHl77j4NZzh13jnvbz4XlPy9sp7ia5leXVqok00anOVu_2U7SjR2JZBrEi8GX__nVN_BofHx4YA-Ko_0dWA93GgWhfgWri4sres1MaOF3G88T8Pu-Xf0vA5YXRg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+HIF+in+Immunity+and+Inflammation&rft.jtitle=Cell+metabolism&rft.au=McGettrick%2C+Anne+F.&rft.au=O%E2%80%99Neill%2C+Luke+A.J.&rft.date=2020-10-06&rft.pub=Elsevier+Inc&rft.issn=1550-4131&rft.eissn=1932-7420&rft.volume=32&rft.issue=4&rft.spage=524&rft.epage=536&rft_id=info:doi/10.1016%2Fj.cmet.2020.08.002&rft.externalDocID=S1550413120304150 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1550-4131&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1550-4131&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1550-4131&client=summon |