The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

• Published in: Cell metabolism Vol. 20; no. 3; pp. 526 - 540
• Main Authors: Zhang, Chen-Song, Jiang, Bin, Li, Mengqi, Zhu, Mingjiang, Peng, Yongying, Zhang, Ya-Lin, Wu, Yu-Qing, Li, Terytty Yang, Liang, Yu, Lu, Zailian, Lian, Guili, Liu, Qing, Guo, Huiling, Yin, Zhenyu, Ye, Zhiyun, Han, Jiahuai, Wu, Jia-Wei, Yin, Huiyong, Lin, Shu-Yong, Lin, Sheng-Cai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.09.2014
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; AMP-Activated Protein Kinases - metabolism; Animals; Axin Protein - metabolism; Cell Line; Endosomes - metabolism; Enzyme Activation; Glucose - metabolism; HEK293 Cells; Humans; Lysosomes - enzymology; Lysosomes - metabolism; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes - metabolism; Protein-Serine-Threonine Kinases - metabolism; Starvation; TOR Serine-Threonine Kinases - metabolism; Vacuolar Proton-Translocating ATPases - metabolism

AMPK and mTOR play principal roles in governing metabolic programs; however, mechanisms underlying the coordination of the two inversely regulated kinases remain unclear. In this study we found, most surprisingly, that the late endosomal/lysosomal protein complex v-ATPase-Ragulator, essential for ac...