Tomato-made edible COVID-19 vaccine TOMAVAC induces neutralizing IgGs in the blood sera of mice and humans

• Published in: Frontiers in nutrition (Lausanne) Vol. 10; p. 1275307
• Main Authors: Buriev, Zabardast T, Shermatov, Shukhrat E, Usmanov, Dilshod E, Mirzakhmedov, Mukhammadjon K, Ubaydullaeva, Khurshida A, Kamburova, Venera S, Rakhmanov, Bakhtiyor K, Ayubov, Mirzakamol S, Abdullaev, Adkham N, Eshmurzaev, Jakhongir B, Mamajonov, Behzod O, Tulanov, Akmal A, Ismailova, Adolat A, Petrova, Tatyana A, Rozumbetov, Ramazan J, Aripova, Tamara U, Muminov, Muzaffar I, Ermatova, Khusnora Y, Dalimova, Dilbar A, Turdikulova, Shahlo U, Abdukarimov, Abdusattor, Abdurakhmonov, Ibrokhim Y
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.01.2024
• Subjects: Edible vaccine; efficiency; Nutrition; RBD-specific neutralizing antibodies; safety; SARS-CoV-2; viral neutralizing activity; RBD-specific neutralizing antibodies; Edible vaccine; SARS-CoV-2; efficiency; viral neutralizing activity; safety

Plant-based edible vaccines that provide two-layered protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outweigh the currently used parenteral types of vaccines, which predominantly cause a systemic immune response. Here, we engineered and selected a transgenic tomato ge...