Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps

• Published in: Frontiers in pediatrics Vol. 11; p. 1163100
• Main Authors: Stroe, Marina-Stefania, Van Bockstal, Lieselotte, Valenzuela, Allan, Ayuso, Miriam, Leys, Karen, Annaert, Pieter, Carpentier, Sebastien, Smits, Anne, Allegaert, Karel, Zeltner, Adrian, Mulder, Antonius, Van Ginneken, Chris, Van Cruchten, Steven
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.05.2023
• Subjects: anesthesia; animal model; pediatric drug development; Pediatrics; perinatal asphyxia; precision dosing; therapeutic hypothermia; pediatric drug development; precision dosing; animal model; perinatal asphyxia; therapeutic hypothermia; anesthesia

Animal models provide useful information on mechanisms in human disease conditions, but also on exploring (patho)physiological factors affecting pharmacokinetics, safety, and efficacy of drugs in development. Also, in pediatric patients, nonclinical data can be critical for better understanding the...