MicroRNA expression profile in plasma from type 1 diabetic patients: Case-control study and bioinformatic analysis
To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan...
Saved in:
| Published in | Diabetes research and clinical practice Vol. 141; pp. 35 - 46 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.07.2018
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0168-8227 1872-8227 1872-8227 |
| DOI | 10.1016/j.diabres.2018.03.044 |
Cover
Loading…
| Abstract | To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved.
Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR. Bioinformatic analyses were performed to determine in which pathways these miRNAs are involved.
Nine miRNAs were differentially expressed between recently-diagnosed T1DM patients (<5 years of diagnosis) and controls. No differences were observed between patients with ≥5 years of diagnosis and controls. After validation in an independent sample of T1DM patients, miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ≥5 years of diagnosis. Moreover, miR-146a-5p was downregulated in recently-diagnosed T1DM patients compared with the other groups. These five miRNAs regulate several genes from innate immune system-, MAPK-, apoptosis-, insulin- and cancer-related pathways.
Five miRNAs are dysregulated in recently-diagnosed T1DM patients and target several genes involved in pathways related to T1DM pathogenesis, thus representing potential T1DM biomarkers. |
|---|---|
| AbstractList | To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved.
Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR. Bioinformatic analyses were performed to determine in which pathways these miRNAs are involved.
Nine miRNAs were differentially expressed between recently-diagnosed T1DM patients (<5 years of diagnosis) and controls. No differences were observed between patients with ≥5 years of diagnosis and controls. After validation in an independent sample of T1DM patients, miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ≥5 years of diagnosis. Moreover, miR-146a-5p was downregulated in recently-diagnosed T1DM patients compared with the other groups. These five miRNAs regulate several genes from innate immune system-, MAPK-, apoptosis-, insulin- and cancer-related pathways.
Five miRNAs are dysregulated in recently-diagnosed T1DM patients and target several genes involved in pathways related to T1DM pathogenesis, thus representing potential T1DM biomarkers. To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved.AIMSTo investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved.Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR. Bioinformatic analyses were performed to determine in which pathways these miRNAs are involved.METHODSExpressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR. Bioinformatic analyses were performed to determine in which pathways these miRNAs are involved.Nine miRNAs were differentially expressed between recently-diagnosed T1DM patients (<5 years of diagnosis) and controls. No differences were observed between patients with ≥5 years of diagnosis and controls. After validation in an independent sample of T1DM patients, miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ≥5 years of diagnosis. Moreover, miR-146a-5p was downregulated in recently-diagnosed T1DM patients compared with the other groups. These five miRNAs regulate several genes from innate immune system-, MAPK-, apoptosis-, insulin- and cancer-related pathways.RESULTSNine miRNAs were differentially expressed between recently-diagnosed T1DM patients (<5 years of diagnosis) and controls. No differences were observed between patients with ≥5 years of diagnosis and controls. After validation in an independent sample of T1DM patients, miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ≥5 years of diagnosis. Moreover, miR-146a-5p was downregulated in recently-diagnosed T1DM patients compared with the other groups. These five miRNAs regulate several genes from innate immune system-, MAPK-, apoptosis-, insulin- and cancer-related pathways.Five miRNAs are dysregulated in recently-diagnosed T1DM patients and target several genes involved in pathways related to T1DM pathogenesis, thus representing potential T1DM biomarkers.CONCLUSIONFive miRNAs are dysregulated in recently-diagnosed T1DM patients and target several genes involved in pathways related to T1DM pathogenesis, thus representing potential T1DM biomarkers. |
| Author | Tschiedel, Balduíno Recamonde-Mendoza, Mariana Crispim, Daisy Puñales, Márcia Assmann, Taís S. Canani, Luís H. |
| Author_xml | – sequence: 1 givenname: Taís S. surname: Assmann fullname: Assmann, Taís S. organization: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil – sequence: 2 givenname: Mariana surname: Recamonde-Mendoza fullname: Recamonde-Mendoza, Mariana organization: Institute of Informatics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil – sequence: 3 givenname: Márcia surname: Puñales fullname: Puñales, Márcia organization: Instituto da Criança com Diabetes, Hospital Nossa Senhora da Conceição, Porto Alegre, Rio Grande do Sul, Brazil – sequence: 4 givenname: Balduíno surname: Tschiedel fullname: Tschiedel, Balduíno organization: Instituto da Criança com Diabetes, Hospital Nossa Senhora da Conceição, Porto Alegre, Rio Grande do Sul, Brazil – sequence: 5 givenname: Luís H. surname: Canani fullname: Canani, Luís H. organization: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil – sequence: 6 givenname: Daisy surname: Crispim fullname: Crispim, Daisy email: dcmoreira@hcpa.edu.br organization: Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29679626$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkU9v1DAQxS1URLeFjwDykUuC_8VJQKiqVrQgFZAQnC3bmUheEnuxvYh8exx2e-mlnGYOv_dG894FOvPBA0IvKakpofLNrh6cNhFSzQjtasJrIsQTtKFdy6qOsfYMbQrX_dvP0UVKO0KI5KJ5hs5ZL9teMrlB8bOzMXz7co3hz764JRc83scwugmwK-uk06zxGMOM87IHTPF6F7KzeK-zA5_TW7zVCSobfI5hwikfhgVrP2DjgvNjiLNece31tCSXnqOno54SvDjNS_Tj5sP37cfq7uvtp-31XWWFlLlqGiFawWzfA-XMtoM0TW9G0hlhiBYNbTkZmJAD1RpGyTUnvG84t6w1nZGGX6LXR9_yzq8DpKxmlyxMk_YQDkkxwrpeyI43BX11Qg9mhkHto5t1XNR9TgV4dwRKWClFGJV1uXy1vqzdpChRaytqp06tqLUVRbgqrRR180B9f-Ax3dVRByWm3w6iSrYkbmFwEWxWQ3CPOrx_4GAn553V009Y_kP_FxOnvyY |
| CitedBy_id | crossref_primary_10_3389_fphys_2020_01091 crossref_primary_10_3390_ijms232112843 crossref_primary_10_1089_ars_2021_0200 crossref_primary_10_1038_s41598_021_00388_2 crossref_primary_10_1016_j_colsurfb_2019_110360 crossref_primary_10_33317_ssurj_652 crossref_primary_10_3390_cells9061557 crossref_primary_10_1152_ajpendo_00122_2019 crossref_primary_10_1186_s12920_021_00931_0 crossref_primary_10_1038_s42003_020_01495_y crossref_primary_10_1093_nutrit_nuae142 crossref_primary_10_1016_j_biopha_2020_110509 crossref_primary_10_3389_fimmu_2022_995610 crossref_primary_10_3390_ncrna7030039 crossref_primary_10_3390_ncrna9020017 crossref_primary_10_1515_dx_2022_0036 crossref_primary_10_2174_1573399818666220118095952 crossref_primary_10_1016_j_mrrev_2022_108442 crossref_primary_10_1002_dmrr_3774 crossref_primary_10_1155_2018_8364608 crossref_primary_10_1016_j_humgen_2023_201191 crossref_primary_10_1186_s12933_023_01988_0 crossref_primary_10_3389_fimmu_2021_744509 crossref_primary_10_1371_journal_pone_0275936 crossref_primary_10_3390_cells8121533 crossref_primary_10_1016_j_imlet_2020_07_008 crossref_primary_10_1093_nar_gkz580 crossref_primary_10_3390_ijms231810635 crossref_primary_10_3390_ijms222111892 crossref_primary_10_1177_11795514231155635 crossref_primary_10_3390_ph15101269 crossref_primary_10_3390_ijms22062953 crossref_primary_10_3390_biomedicines10092136 crossref_primary_10_4239_wjd_v14_i9_1334 crossref_primary_10_1096_fj_202401464R crossref_primary_10_1007_s13237_021_00376_x crossref_primary_10_1016_j_jdiacomp_2018_08_012 crossref_primary_10_1016_j_isci_2024_110956 crossref_primary_10_3892_etm_2021_10407 crossref_primary_10_1007_s00125_019_05026_1 crossref_primary_10_1016_j_xcrm_2024_101591 crossref_primary_10_3390_ijms21072437 crossref_primary_10_1016_j_compbiomed_2022_105558 crossref_primary_10_1210_endrev_bnab021 crossref_primary_10_1016_j_bbrc_2024_150388 crossref_primary_10_1097_CM9_0000000000001450 crossref_primary_10_1007_s00011_022_01643_6 crossref_primary_10_3390_ijms222212165 crossref_primary_10_2337_db20_0817 crossref_primary_10_3389_fnut_2020_612115 |
| Cites_doi | 10.1186/1756-0500-6-491 10.1038/nrendo.2013.86 10.1016/j.bbadis.2009.02.013 10.1096/fj.15-273649 10.1007/s00125-016-4156-4 10.1038/nrm3313 10.1530/EC-17-0248 10.1172/jci.insight.89656 10.1006/meth.2001.1262 10.1074/jbc.M111.337154 10.7554/eLife.05005 10.18632/oncotarget.13447 10.1038/nrg3074 10.2337/dc15-S005 10.1093/nar/gkv1258 10.1093/nar/gkt1181 10.2337/db12-1398 10.1111/1753-0407.12163 10.1093/nar/gkt393 10.1007/978-1-4939-3578-9_4 10.3389/fimmu.2014.00578 10.1093/nar/gkv1070 10.2337/dc15-0101 10.1016/j.jaut.2009.02.012 10.1038/nature10112 10.1097/MED.0b013e32832e0693 10.1155/2015/749734 10.1006/geno.2002.6748 10.18632/oncotarget.3052 10.1093/nar/gkn851 10.1172/JCI78090 10.1038/srep31479 10.1038/nm.3862 10.1038/nmeth.3485 10.1007/s00592-016-0961-y 10.1007/s13105-015-0413-0 10.1210/jc.2013-3868 10.4049/jimmunol.1000491 10.1002/iub.427 10.1016/j.cell.2010.08.012 10.1007/s00125-015-3510-2 10.1373/clinchem.2008.112797 10.1038/ng1201-365 10.1093/jmcb/mjr007 10.18637/jss.v040.i01 10.1016/j.jclinepi.2007.11.008 10.2337/db09-0881 10.1016/j.gene.2014.01.075 10.1590/S0004-27302008000200002 10.1093/nar/gkt1248 10.1155/2015/303987 10.1038/ni.f.209 10.1261/rna.2239606 10.2337/dc08-1987 10.1038/nrc3932 10.1016/j.bbrc.2010.04.116 10.1089/omi.2011.0118 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier B.V. Copyright © 2018 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier B.V. – notice: Copyright © 2018 Elsevier B.V. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.diabres.2018.03.044 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1872-8227 |
| EndPage | 46 |
| ExternalDocumentID | 29679626 10_1016_j_diabres_2018_03_044 S0168822717320363 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5RE 5VS 6PF 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AATTM AAWTL AAXKI AAXUO AAYWO ABBQC ABFNM ABGSF ABJNI ABMAC ABMZM ABUDA ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADUVX ADVLN AEBSH AEHWI AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDZ HMK HMO HVGLF HZ~ IHE J1W KOM LZ1 M29 M41 MO0 N9A O-L O9- OAUVE OB0 ON- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SEL SES SEW SPCBC SSH SSU SSZ T5K WUQ X7M Z5R ZGI ~G- 6I. AACTN AAFTH AAIAV ABLVK ABYKQ AFKWA AHPSJ AJBFU AJOXV AMFUW DOVZS EFLBG LCYCR RIG ZA5 AAYXX AFCTW AGRNS CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c466t-5544742c99e132c7d6b59bf08b4b0a451730d246d1aaef63a3039533c27b8b6b3 |
| IEDL.DBID | AIKHN |
| ISSN | 0168-8227 1872-8227 |
| IngestDate | Thu Sep 04 18:47:04 EDT 2025 Thu Apr 03 07:00:40 EDT 2025 Tue Jul 01 01:02:43 EDT 2025 Thu Apr 24 23:01:18 EDT 2025 Fri Feb 23 02:26:46 EST 2024 Tue Aug 26 16:32:19 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Epigenetics Macroarray miRNAs Type 1 diabetes In silico analysis |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2018 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c466t-5544742c99e132c7d6b59bf08b4b0a451730d246d1aaef63a3039533c27b8b6b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0168822717320363 |
| PMID | 29679626 |
| PQID | 2028946835 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_2028946835 pubmed_primary_29679626 crossref_citationtrail_10_1016_j_diabres_2018_03_044 crossref_primary_10_1016_j_diabres_2018_03_044 elsevier_sciencedirect_doi_10_1016_j_diabres_2018_03_044 elsevier_clinicalkey_doi_10_1016_j_diabres_2018_03_044 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-07-01 |
| PublicationDateYYYYMMDD | 2018-07-01 |
| PublicationDate_xml | – month: 07 year: 2018 text: 2018-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Diabetes research and clinical practice |
| PublicationTitleAlternate | Diabetes Res Clin Pract |
| PublicationYear | 2018 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Trajkovski, Hausser, Soutschek, Bhat, Akin, Zavolan (b0205) 2011; 474 Assmann TS, Recamonde-Mendoza M, de Souza BM, Crispim D. MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatics analysis. Endocr Connect.; 2017. Abuhatzira, Xu, Tahhan, Boulougoura, Schaffer, Notkins (b0075) 2015; 29 Bustin, Benes, Garson, Hellemans, Huggett, Kubista (b0105) 2009; 55 Esteller (b0025) 2011; 12 Mortensen, Hougaard, Swift, Hansen, Holl, Hoey (b0100) 2009; 32 Kozomara, Griffiths-Jones (b0155) 2014; 42 Devlin, Greco, Martelli, Ivan (b0265) 2011; 63 Dweep (b0110) 2015; 12 Aly, Gottlieb (b0015) 2009; 16 Livak, Schmittgen (b0115) 2001; 25 Takahashi, Xavier, Evangelista, Manoel-Caetano, Macedo, Collares (b0055) 2014; 539 Wang, Hou, Lin, Wang, Liu, Li (b0235) 2010; 185 Humphries, Yang (b0245) 2015; 6 Osipova, Fischer, Dangwal, Volkmann, Widera, Schwarz (b0270) 2014; 99 Li, Liu, Zhou, Qu, Yang (b0130) 2014; 42 Lu, Boldin, Chaudhry, Lin, Taganov, Hanada (b0275) 2010; 142 Sethupathy, Corda, Hatzigeorgiou (b0140) 2006; 12 Brazma, Hingamp, Quackenbush, Sherlock, Spellman, Stoeckert (b0120) 2001; 29 Fayyad-Kazan, Rouas, Fayyad-Kazan, Badran, El Zein, Lewalle (b0260) 2012; 287 Bonifacio (b0190) 2015; 38 Guay, Regazzi (b0010) 2013; 9 Seyhan, Nunez Lopez, Xie, Yi, Mathews, Pasarica (b0030) 2016; 6 Yang, Ye, Wang, Gao, Liu, Hong (b0060) 2015; 7 von Elm, Altman, Egger, Pocock, Gotzsche, Vandenbroucke (b0085) 2008; 61 Chou, Chang, Shrestha, Hsu, Lin, Lee (b0125) 2016; 44 Wickham (b0180) 2011; 40 Baltimore, Boldin, O'Connell, Rao, Taganov (b0285) 2008; 9 Rottiers, Naar (b0220) 2012; 13 Lin, Gregory (b0035) 2015; 15 Wain, Bruford, Lovering, Lush, Wright, Povey (b0160) 2002; 79 Nguyen, Varney, Harrison, Morahan (b0095) 2013; 62 Xiao, Zuo, Cai, Kang, Gao, Li (b0135) 2009; 37 Assmann, Duarte, Brondani, de Freitas, Martins, Canani (b0090) 2017 Samandari, Mirza, Nielsen, Kaur, Hougaard, Fredheim (b0080) 2017; 60 Ma, Becker Buscaglia, Barker, Li (b0230) 2011; 3 Collares, Evangelista, Xavier, Rassi, Arns, Foss-Freitas (b0210) 2013; 6 Paraskevopoulou, Georgakilas, Kostoulas, Vlachos, Vergoulis, Reczko (b0150) 2013; 41 Eisenbarth, Jeffrey (b0185) 2008; 52 Carlson, Pages, Arora, Obenchain, Morgan (b0175) 2016; 1418 Saba, Sorensen, Booth (b0280) 2014; 5 Kanehisa, Sato, Kawashima, Furumichi, Tanabe (b0165) 2016; 44 Faraoni, Antonetti, Cardone, Bonmassar (b0225) 2009; 1792 Zalts, Shomron (b0045) 2011; 8 Ventriglia, Nigi, Sebastiani, Dotta (b0295) 2015; 2015 Hennessy, Clynes, Jeppesen, O'Driscoll (b0255) 2010; 396 Lu, Xie, Geng, Shen, Sui, Yang (b0195) 2015; 2015 Agarwal V, Bell GW, Nam JW, Bartel DP. Predicting effective microRNA target sites in mammalian mRNAs. eLife. 2015;4. Khamaneh, Alipour, Sheikhzadeh Hesari, Ghadiri (b0240) 2015; 71 Simpson, Ansel (b0290) 2015; 125 Nielsen, Wang, Sorensen, Bang-Berthelsen, Hansen, Andersen (b0020) 2012; 2012 Kfir-Erenfeld, Haggiag, Biton, Stepensky, Assayag-Asherie, Yefenof (b0215) 2017; 8 Erener, Marwaha, Tan, Panagiotopoulos, Kieffer (b0065) 2017; 2 Belgardt, Ahmed, Spranger, Latreille, Denzler, Kondratiuk (b0250) 2015; 21 American Diabetes Association (b0005) 2015; 38 Roggli, Britan, Gattesco, Lin-Marq, Abderrahmani, Meda (b0050) 2010; 59 Pauley, Cha, Chan (b0040) 2009; 32 Yu, Wang, Han, He (b0170) 2012; 16 Zhu, Leung (b0200) 2015; 58 Wickham (10.1016/j.diabres.2018.03.044_b0180) 2011; 40 Eisenbarth (10.1016/j.diabres.2018.03.044_b0185) 2008; 52 Pauley (10.1016/j.diabres.2018.03.044_b0040) 2009; 32 Roggli (10.1016/j.diabres.2018.03.044_b0050) 2010; 59 Zhu (10.1016/j.diabres.2018.03.044_b0200) 2015; 58 Nguyen (10.1016/j.diabres.2018.03.044_b0095) 2013; 62 Faraoni (10.1016/j.diabres.2018.03.044_b0225) 2009; 1792 Fayyad-Kazan (10.1016/j.diabres.2018.03.044_b0260) 2012; 287 Esteller (10.1016/j.diabres.2018.03.044_b0025) 2011; 12 Kfir-Erenfeld (10.1016/j.diabres.2018.03.044_b0215) 2017; 8 Paraskevopoulou (10.1016/j.diabres.2018.03.044_b0150) 2013; 41 Lu (10.1016/j.diabres.2018.03.044_b0275) 2010; 142 Takahashi (10.1016/j.diabres.2018.03.044_b0055) 2014; 539 Brazma (10.1016/j.diabres.2018.03.044_b0120) 2001; 29 Yu (10.1016/j.diabres.2018.03.044_b0170) 2012; 16 Wang (10.1016/j.diabres.2018.03.044_b0235) 2010; 185 Hennessy (10.1016/j.diabres.2018.03.044_b0255) 2010; 396 Trajkovski (10.1016/j.diabres.2018.03.044_b0205) 2011; 474 Humphries (10.1016/j.diabres.2018.03.044_b0245) 2015; 6 Saba (10.1016/j.diabres.2018.03.044_b0280) 2014; 5 Osipova (10.1016/j.diabres.2018.03.044_b0270) 2014; 99 Kozomara (10.1016/j.diabres.2018.03.044_b0155) 2014; 42 Simpson (10.1016/j.diabres.2018.03.044_b0290) 2015; 125 Khamaneh (10.1016/j.diabres.2018.03.044_b0240) 2015; 71 Livak (10.1016/j.diabres.2018.03.044_b0115) 2001; 25 10.1016/j.diabres.2018.03.044_b0145 Carlson (10.1016/j.diabres.2018.03.044_b0175) 2016; 1418 Sethupathy (10.1016/j.diabres.2018.03.044_b0140) 2006; 12 Guay (10.1016/j.diabres.2018.03.044_b0010) 2013; 9 Bustin (10.1016/j.diabres.2018.03.044_b0105) 2009; 55 Chou (10.1016/j.diabres.2018.03.044_b0125) 2016; 44 Seyhan (10.1016/j.diabres.2018.03.044_b0030) 2016; 6 Zalts (10.1016/j.diabres.2018.03.044_b0045) 2011; 8 Yang (10.1016/j.diabres.2018.03.044_b0060) 2015; 7 10.1016/j.diabres.2018.03.044_b0070 Lu (10.1016/j.diabres.2018.03.044_b0195) 2015; 2015 American Diabetes Association (10.1016/j.diabres.2018.03.044_b0005) 2015; 38 Assmann (10.1016/j.diabres.2018.03.044_b0090) 2017 Kanehisa (10.1016/j.diabres.2018.03.044_b0165) 2016; 44 Xiao (10.1016/j.diabres.2018.03.044_b0135) 2009; 37 Dweep (10.1016/j.diabres.2018.03.044_b0110) 2015; 12 Bonifacio (10.1016/j.diabres.2018.03.044_b0190) 2015; 38 Devlin (10.1016/j.diabres.2018.03.044_b0265) 2011; 63 Belgardt (10.1016/j.diabres.2018.03.044_b0250) 2015; 21 Samandari (10.1016/j.diabres.2018.03.044_b0080) 2017; 60 Aly (10.1016/j.diabres.2018.03.044_b0015) 2009; 16 Baltimore (10.1016/j.diabres.2018.03.044_b0285) 2008; 9 Ventriglia (10.1016/j.diabres.2018.03.044_b0295) 2015; 2015 Mortensen (10.1016/j.diabres.2018.03.044_b0100) 2009; 32 von Elm (10.1016/j.diabres.2018.03.044_b0085) 2008; 61 Abuhatzira (10.1016/j.diabres.2018.03.044_b0075) 2015; 29 Nielsen (10.1016/j.diabres.2018.03.044_b0020) 2012; 2012 Wain (10.1016/j.diabres.2018.03.044_b0160) 2002; 79 Li (10.1016/j.diabres.2018.03.044_b0130) 2014; 42 Rottiers (10.1016/j.diabres.2018.03.044_b0220) 2012; 13 Ma (10.1016/j.diabres.2018.03.044_b0230) 2011; 3 Collares (10.1016/j.diabres.2018.03.044_b0210) 2013; 6 Lin (10.1016/j.diabres.2018.03.044_b0035) 2015; 15 Erener (10.1016/j.diabres.2018.03.044_b0065) 2017; 2 |
| References_xml | – volume: 2015 start-page: 303987 year: 2015 ident: b0195 article-title: Potential role of MicroRNA-210 as biomarker in human cancers detection: a meta-analysis publication-title: BioMed Res Int – volume: 52 start-page: 146 year: 2008 end-page: 155 ident: b0185 article-title: The natural history of type 1A diabetes publication-title: Arq Bras Endocrinol Metabol – volume: 6 start-page: 491 year: 2013 ident: b0210 article-title: Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients publication-title: BMC Res Notes – volume: 8 start-page: 354 year: 2011 end-page: 362 ident: b0045 article-title: The impact of microRNAs on endocrinology publication-title: Pediatr Endocrinol Rev – volume: 13 start-page: 239 year: 2012 end-page: 250 ident: b0220 article-title: MicroRNAs in metabolism and metabolic disorders publication-title: Nat Rev Mol Cell Biol – volume: 6 start-page: 6472 year: 2015 end-page: 6498 ident: b0245 article-title: The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy publication-title: Oncotarget – volume: 142 start-page: 914 year: 2010 end-page: 929 ident: b0275 article-title: Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses publication-title: Cell – volume: 41 start-page: W169 year: 2013 end-page: W173 ident: b0150 article-title: DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows publication-title: Nucl Acids Res – volume: 71 start-page: 301 year: 2015 end-page: 309 ident: b0240 article-title: A signature of microRNA-155 in the pathogenesis of diabetic complications publication-title: J Physiol Biochem – volume: 60 start-page: 354 year: 2017 end-page: 363 ident: b0080 article-title: Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus publication-title: Diabetologia – volume: 29 start-page: 4374 year: 2015 end-page: 4383 ident: b0075 article-title: Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2beta, and GAD65 publication-title: FASEB J – volume: 37 start-page: D105 year: 2009 end-page: D110 ident: b0135 article-title: MiRecords: an integrated resource for microRNA-target interactions publication-title: Nucl Acids Res – volume: 59 start-page: 978 year: 2010 end-page: 986 ident: b0050 article-title: Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells publication-title: Diabetes – volume: 396 start-page: 457 year: 2010 end-page: 462 ident: b0255 article-title: Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells publication-title: Biochem Biophys Res Commun – volume: 62 start-page: 2135 year: 2013 end-page: 2140 ident: b0095 article-title: Definition of high-risk type 1 diabetes HLA-DR and HLA-DQ types using only three single nucleotide polymorphisms publication-title: Diabetes – volume: 12 start-page: 697 year: 2015 ident: b0110 article-title: Gretz N. miRWalk2.0: a comprehensive atlas of microRNA-target interactions publication-title: Nat Methods – volume: 287 start-page: 9910 year: 2012 end-page: 9922 ident: b0260 article-title: MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function publication-title: J Biol Chem – volume: 58 start-page: 900 year: 2015 end-page: 911 ident: b0200 article-title: Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies publication-title: Diabetologia – volume: 63 start-page: 94 year: 2011 end-page: 100 ident: b0265 article-title: MiR-210: more than a silent player in hypoxia publication-title: IUBMB Life – volume: 16 start-page: 286 year: 2009 end-page: 292 ident: b0015 article-title: The honeymoon phase: intersection of metabolism and immunology publication-title: Curr Opin Endocrinol Diabetes Obes – volume: 1418 start-page: 67 year: 2016 end-page: 90 ident: b0175 article-title: Genomic annotation resources in R/Bioconductor publication-title: Methods Mol Biol – volume: 5 start-page: 578 year: 2014 ident: b0280 article-title: MicroRNA-146a: a dominant, negative regulator of the innate immune response publication-title: Front Immunol – volume: 7 start-page: 158 year: 2015 end-page: 165 ident: b0060 article-title: Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients publication-title: J Diabetes – year: 2017 ident: b0090 article-title: Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus publication-title: Acta Diabetol – volume: 8 start-page: 472 year: 2017 end-page: 489 ident: b0215 article-title: MiR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis publication-title: Oncotarget – volume: 79 start-page: 464 year: 2002 end-page: 470 ident: b0160 article-title: Guidelines for human gene nomenclature publication-title: Genomics – volume: 2 start-page: e89656 year: 2017 ident: b0065 article-title: Profiling of circulating microRNAs in children with recent onset of type 1 diabetes publication-title: JCI Insight – volume: 2015 start-page: 749734 year: 2015 ident: b0295 article-title: MicroRNAs: novel players in the dialogue between pancreatic islets and immune system in autoimmune diabetes publication-title: BioMed Res Int – volume: 21 start-page: 619 year: 2015 end-page: 627 ident: b0250 article-title: The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes publication-title: Nat Med – volume: 61 start-page: 344 year: 2008 end-page: 349 ident: b0085 article-title: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies publication-title: J Clin Epidemiol – volume: 99 start-page: E1661 year: 2014 end-page: E1665 ident: b0270 article-title: Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study publication-title: J Clin Endocrinol Metab – volume: 32 start-page: 1384 year: 2009 end-page: 1390 ident: b0100 article-title: New definition for the partial remission period in children and adolescents with type 1 diabetes publication-title: Diabetes Care – volume: 1792 start-page: 497 year: 2009 end-page: 505 ident: b0225 article-title: MiR-155 gene: a typical multifunctional microRNA publication-title: Biochim Biophys Acta – volume: 6 start-page: 31479 year: 2016 ident: b0030 article-title: Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study publication-title: Sci Rep – volume: 12 start-page: 192 year: 2006 end-page: 197 ident: b0140 article-title: TarBase: a comprehensive database of experimentally supported animal microRNA targets publication-title: RNA – volume: 12 start-page: 861 year: 2011 end-page: 874 ident: b0025 article-title: Non-coding RNAs in human disease publication-title: Nat Rev Genet – volume: 29 start-page: 365 year: 2001 end-page: 371 ident: b0120 article-title: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data publication-title: Nat Genetics – volume: 474 start-page: 649 year: 2011 end-page: 653 ident: b0205 article-title: MicroRNAs 103 and 107 regulate insulin sensitivity publication-title: Nature – volume: 32 start-page: 189 year: 2009 end-page: 194 ident: b0040 article-title: MicroRNA in autoimmunity and autoimmune diseases publication-title: J Autoimmun – volume: 44 start-page: D239 year: 2016 end-page: D247 ident: b0125 article-title: MiRTarBase 2016: updates to the experimentally validated miRNA-target interactions database publication-title: Nucl Acids Res – reference: Assmann TS, Recamonde-Mendoza M, de Souza BM, Crispim D. MicroRNA expression profiles and type 1 diabetes mellitus: systematic review and bioinformatics analysis. Endocr Connect.; 2017. – volume: 3 start-page: 159 year: 2011 end-page: 166 ident: b0230 article-title: MicroRNAs in NF-kappaB signaling publication-title: J Mol Cell Biol – volume: 2012 start-page: 896362 year: 2012 ident: b0020 article-title: Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression publication-title: Exp Diabetes Res – volume: 44 start-page: D457 year: 2016 end-page: D462 ident: b0165 article-title: KEGG as a reference resource for gene and protein annotation publication-title: Nucl Acids Res – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: b0115 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods – volume: 42 start-page: D68 year: 2014 end-page: D73 ident: b0155 article-title: MiRBase: annotating high confidence microRNAs using deep sequencing data publication-title: Nucl Acids Res – volume: 55 start-page: 611 year: 2009 end-page: 622 ident: b0105 article-title: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments publication-title: Clin Chem – volume: 40 start-page: 1 year: 2011 end-page: 29 ident: b0180 article-title: The split-apply-combine strategy for data analysis publication-title: J Statistical Software – volume: 9 start-page: 839 year: 2008 end-page: 845 ident: b0285 article-title: MicroRNAs: new regulators of immune cell development and function publication-title: Nat Immunol – volume: 539 start-page: 213 year: 2014 end-page: 223 ident: b0055 article-title: MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus publication-title: Gene – volume: 16 start-page: 284 year: 2012 end-page: 287 ident: b0170 article-title: ClusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS – volume: 38 start-page: S8 year: 2015 end-page: S16 ident: b0005 article-title: Classification and diagnosis of diabetes publication-title: Diabetes Care – reference: Agarwal V, Bell GW, Nam JW, Bartel DP. Predicting effective microRNA target sites in mammalian mRNAs. eLife. 2015;4. – volume: 9 start-page: 513 year: 2013 end-page: 521 ident: b0010 article-title: Circulating microRNAs as novel biomarkers for diabetes mellitus publication-title: Nat Rev Endocrinol – volume: 42 start-page: D92 year: 2014 end-page: D97 ident: b0130 article-title: starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data publication-title: Nucl Acids Res – volume: 125 start-page: 2242 year: 2015 end-page: 2249 ident: b0290 article-title: MicroRNA regulation of lymphocyte tolerance and autoimmunity publication-title: J Clin Invest – volume: 15 start-page: 321 year: 2015 end-page: 333 ident: b0035 article-title: MicroRNA biogenesis pathways in cancer publication-title: Nat Rev Cancer – volume: 38 start-page: 989 year: 2015 end-page: 996 ident: b0190 article-title: Predicting type 1 diabetes using biomarkers publication-title: Diabetes Care – volume: 185 start-page: 6226 year: 2010 end-page: 6233 ident: b0235 article-title: Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1 publication-title: J Immunol – volume: 6 start-page: 491 year: 2013 ident: 10.1016/j.diabres.2018.03.044_b0210 article-title: Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients publication-title: BMC Res Notes doi: 10.1186/1756-0500-6-491 – volume: 9 start-page: 513 year: 2013 ident: 10.1016/j.diabres.2018.03.044_b0010 article-title: Circulating microRNAs as novel biomarkers for diabetes mellitus publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2013.86 – volume: 1792 start-page: 497 year: 2009 ident: 10.1016/j.diabres.2018.03.044_b0225 article-title: MiR-155 gene: a typical multifunctional microRNA publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2009.02.013 – volume: 29 start-page: 4374 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0075 article-title: Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2beta, and GAD65 publication-title: FASEB J doi: 10.1096/fj.15-273649 – volume: 60 start-page: 354 year: 2017 ident: 10.1016/j.diabres.2018.03.044_b0080 article-title: Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus publication-title: Diabetologia doi: 10.1007/s00125-016-4156-4 – volume: 13 start-page: 239 year: 2012 ident: 10.1016/j.diabres.2018.03.044_b0220 article-title: MicroRNAs in metabolism and metabolic disorders publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3313 – ident: 10.1016/j.diabres.2018.03.044_b0070 doi: 10.1530/EC-17-0248 – volume: 2 start-page: e89656 year: 2017 ident: 10.1016/j.diabres.2018.03.044_b0065 article-title: Profiling of circulating microRNAs in children with recent onset of type 1 diabetes publication-title: JCI Insight doi: 10.1172/jci.insight.89656 – volume: 25 start-page: 402 year: 2001 ident: 10.1016/j.diabres.2018.03.044_b0115 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 287 start-page: 9910 year: 2012 ident: 10.1016/j.diabres.2018.03.044_b0260 article-title: MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function publication-title: J Biol Chem doi: 10.1074/jbc.M111.337154 – ident: 10.1016/j.diabres.2018.03.044_b0145 doi: 10.7554/eLife.05005 – volume: 8 start-page: 472 year: 2017 ident: 10.1016/j.diabres.2018.03.044_b0215 article-title: MiR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis publication-title: Oncotarget doi: 10.18632/oncotarget.13447 – volume: 8 start-page: 354 year: 2011 ident: 10.1016/j.diabres.2018.03.044_b0045 article-title: The impact of microRNAs on endocrinology publication-title: Pediatr Endocrinol Rev – volume: 12 start-page: 861 year: 2011 ident: 10.1016/j.diabres.2018.03.044_b0025 article-title: Non-coding RNAs in human disease publication-title: Nat Rev Genet doi: 10.1038/nrg3074 – volume: 38 start-page: S8 issue: Suppl year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0005 article-title: Classification and diagnosis of diabetes publication-title: Diabetes Care doi: 10.2337/dc15-S005 – volume: 44 start-page: D239 year: 2016 ident: 10.1016/j.diabres.2018.03.044_b0125 article-title: MiRTarBase 2016: updates to the experimentally validated miRNA-target interactions database publication-title: Nucl Acids Res doi: 10.1093/nar/gkv1258 – volume: 42 start-page: D68 year: 2014 ident: 10.1016/j.diabres.2018.03.044_b0155 article-title: MiRBase: annotating high confidence microRNAs using deep sequencing data publication-title: Nucl Acids Res doi: 10.1093/nar/gkt1181 – volume: 62 start-page: 2135 year: 2013 ident: 10.1016/j.diabres.2018.03.044_b0095 article-title: Definition of high-risk type 1 diabetes HLA-DR and HLA-DQ types using only three single nucleotide polymorphisms publication-title: Diabetes doi: 10.2337/db12-1398 – volume: 7 start-page: 158 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0060 article-title: Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients publication-title: J Diabetes doi: 10.1111/1753-0407.12163 – volume: 41 start-page: W169 year: 2013 ident: 10.1016/j.diabres.2018.03.044_b0150 article-title: DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows publication-title: Nucl Acids Res doi: 10.1093/nar/gkt393 – volume: 1418 start-page: 67 year: 2016 ident: 10.1016/j.diabres.2018.03.044_b0175 article-title: Genomic annotation resources in R/Bioconductor publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-3578-9_4 – volume: 5 start-page: 578 year: 2014 ident: 10.1016/j.diabres.2018.03.044_b0280 article-title: MicroRNA-146a: a dominant, negative regulator of the innate immune response publication-title: Front Immunol doi: 10.3389/fimmu.2014.00578 – volume: 44 start-page: D457 year: 2016 ident: 10.1016/j.diabres.2018.03.044_b0165 article-title: KEGG as a reference resource for gene and protein annotation publication-title: Nucl Acids Res doi: 10.1093/nar/gkv1070 – volume: 38 start-page: 989 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0190 article-title: Predicting type 1 diabetes using biomarkers publication-title: Diabetes Care doi: 10.2337/dc15-0101 – volume: 32 start-page: 189 year: 2009 ident: 10.1016/j.diabres.2018.03.044_b0040 article-title: MicroRNA in autoimmunity and autoimmune diseases publication-title: J Autoimmun doi: 10.1016/j.jaut.2009.02.012 – volume: 474 start-page: 649 year: 2011 ident: 10.1016/j.diabres.2018.03.044_b0205 article-title: MicroRNAs 103 and 107 regulate insulin sensitivity publication-title: Nature doi: 10.1038/nature10112 – volume: 16 start-page: 286 year: 2009 ident: 10.1016/j.diabres.2018.03.044_b0015 article-title: The honeymoon phase: intersection of metabolism and immunology publication-title: Curr Opin Endocrinol Diabetes Obes doi: 10.1097/MED.0b013e32832e0693 – volume: 2015 start-page: 749734 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0295 article-title: MicroRNAs: novel players in the dialogue between pancreatic islets and immune system in autoimmune diabetes publication-title: BioMed Res Int doi: 10.1155/2015/749734 – volume: 79 start-page: 464 year: 2002 ident: 10.1016/j.diabres.2018.03.044_b0160 article-title: Guidelines for human gene nomenclature publication-title: Genomics doi: 10.1006/geno.2002.6748 – volume: 6 start-page: 6472 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0245 article-title: The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy publication-title: Oncotarget doi: 10.18632/oncotarget.3052 – volume: 37 start-page: D105 year: 2009 ident: 10.1016/j.diabres.2018.03.044_b0135 article-title: MiRecords: an integrated resource for microRNA-target interactions publication-title: Nucl Acids Res doi: 10.1093/nar/gkn851 – volume: 125 start-page: 2242 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0290 article-title: MicroRNA regulation of lymphocyte tolerance and autoimmunity publication-title: J Clin Invest doi: 10.1172/JCI78090 – volume: 6 start-page: 31479 year: 2016 ident: 10.1016/j.diabres.2018.03.044_b0030 article-title: Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study publication-title: Sci Rep doi: 10.1038/srep31479 – volume: 21 start-page: 619 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0250 article-title: The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes publication-title: Nat Med doi: 10.1038/nm.3862 – volume: 12 start-page: 697 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0110 article-title: Gretz N. miRWalk2.0: a comprehensive atlas of microRNA-target interactions publication-title: Nat Methods doi: 10.1038/nmeth.3485 – year: 2017 ident: 10.1016/j.diabres.2018.03.044_b0090 article-title: Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus publication-title: Acta Diabetol doi: 10.1007/s00592-016-0961-y – volume: 71 start-page: 301 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0240 article-title: A signature of microRNA-155 in the pathogenesis of diabetic complications publication-title: J Physiol Biochem doi: 10.1007/s13105-015-0413-0 – volume: 99 start-page: E1661 year: 2014 ident: 10.1016/j.diabres.2018.03.044_b0270 article-title: Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-3868 – volume: 185 start-page: 6226 year: 2010 ident: 10.1016/j.diabres.2018.03.044_b0235 article-title: Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1 publication-title: J Immunol doi: 10.4049/jimmunol.1000491 – volume: 63 start-page: 94 year: 2011 ident: 10.1016/j.diabres.2018.03.044_b0265 article-title: MiR-210: more than a silent player in hypoxia publication-title: IUBMB Life doi: 10.1002/iub.427 – volume: 142 start-page: 914 year: 2010 ident: 10.1016/j.diabres.2018.03.044_b0275 article-title: Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses publication-title: Cell doi: 10.1016/j.cell.2010.08.012 – volume: 58 start-page: 900 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0200 article-title: Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies publication-title: Diabetologia doi: 10.1007/s00125-015-3510-2 – volume: 55 start-page: 611 year: 2009 ident: 10.1016/j.diabres.2018.03.044_b0105 article-title: The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments publication-title: Clin Chem doi: 10.1373/clinchem.2008.112797 – volume: 29 start-page: 365 year: 2001 ident: 10.1016/j.diabres.2018.03.044_b0120 article-title: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data publication-title: Nat Genetics doi: 10.1038/ng1201-365 – volume: 3 start-page: 159 year: 2011 ident: 10.1016/j.diabres.2018.03.044_b0230 article-title: MicroRNAs in NF-kappaB signaling publication-title: J Mol Cell Biol doi: 10.1093/jmcb/mjr007 – volume: 40 start-page: 1 year: 2011 ident: 10.1016/j.diabres.2018.03.044_b0180 article-title: The split-apply-combine strategy for data analysis publication-title: J Statistical Software doi: 10.18637/jss.v040.i01 – volume: 61 start-page: 344 year: 2008 ident: 10.1016/j.diabres.2018.03.044_b0085 article-title: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2007.11.008 – volume: 59 start-page: 978 year: 2010 ident: 10.1016/j.diabres.2018.03.044_b0050 article-title: Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells publication-title: Diabetes doi: 10.2337/db09-0881 – volume: 539 start-page: 213 year: 2014 ident: 10.1016/j.diabres.2018.03.044_b0055 article-title: MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus publication-title: Gene doi: 10.1016/j.gene.2014.01.075 – volume: 52 start-page: 146 year: 2008 ident: 10.1016/j.diabres.2018.03.044_b0185 article-title: The natural history of type 1A diabetes publication-title: Arq Bras Endocrinol Metabol doi: 10.1590/S0004-27302008000200002 – volume: 42 start-page: D92 year: 2014 ident: 10.1016/j.diabres.2018.03.044_b0130 article-title: starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data publication-title: Nucl Acids Res doi: 10.1093/nar/gkt1248 – volume: 2015 start-page: 303987 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0195 article-title: Potential role of MicroRNA-210 as biomarker in human cancers detection: a meta-analysis publication-title: BioMed Res Int doi: 10.1155/2015/303987 – volume: 9 start-page: 839 year: 2008 ident: 10.1016/j.diabres.2018.03.044_b0285 article-title: MicroRNAs: new regulators of immune cell development and function publication-title: Nat Immunol doi: 10.1038/ni.f.209 – volume: 12 start-page: 192 year: 2006 ident: 10.1016/j.diabres.2018.03.044_b0140 article-title: TarBase: a comprehensive database of experimentally supported animal microRNA targets publication-title: RNA doi: 10.1261/rna.2239606 – volume: 32 start-page: 1384 year: 2009 ident: 10.1016/j.diabres.2018.03.044_b0100 article-title: New definition for the partial remission period in children and adolescents with type 1 diabetes publication-title: Diabetes Care doi: 10.2337/dc08-1987 – volume: 15 start-page: 321 year: 2015 ident: 10.1016/j.diabres.2018.03.044_b0035 article-title: MicroRNA biogenesis pathways in cancer publication-title: Nat Rev Cancer doi: 10.1038/nrc3932 – volume: 396 start-page: 457 year: 2010 ident: 10.1016/j.diabres.2018.03.044_b0255 article-title: Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2010.04.116 – volume: 16 start-page: 284 year: 2012 ident: 10.1016/j.diabres.2018.03.044_b0170 article-title: ClusterProfiler: an R package for comparing biological themes among gene clusters publication-title: OMICS doi: 10.1089/omi.2011.0118 – volume: 2012 start-page: 896362 year: 2012 ident: 10.1016/j.diabres.2018.03.044_b0020 article-title: Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression publication-title: Exp Diabetes Res |
| SSID | ssj0006345 |
| Score | 2.4369361 |
| Snippet | To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved.... To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved.AIMSTo... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 35 |
| SubjectTerms | Epigenetics In silico analysis Macroarray miRNAs Type 1 diabetes |
| Title | MicroRNA expression profile in plasma from type 1 diabetic patients: Case-control study and bioinformatic analysis |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0168822717320363 https://dx.doi.org/10.1016/j.diabres.2018.03.044 https://www.ncbi.nlm.nih.gov/pubmed/29679626 https://www.proquest.com/docview/2028946835 |
| Volume | 141 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NT9swFH-CIk27TMDY6PiQkXZNmziOa3OrKlAB0QMDiZtlO64UBCliRdppf_veS5yiHRCIWxL5KYnf8_v8-RngZ2bLbC5KlaRB20Q4vLIp94m2IghFDU9Cg7aYyemNOL8tbtdg0u2FIVhl1P2tTm-0dXwyjLM5fKyq4S90VtA95FRGpmpavg4bPNey6MHG-OxiOlspZJmLFskoVUIELxt5hncDSnFiYEsgL9W0OxXiNRP1mgvamKLTTfgSfUg2bj9zC9ZCvQ2fLmOV_Cs8XRLK7mo2ZuFPxLnWLB7OzSq8RI_5wTLaWcIoBcsy1qZgK89in9Xfx2yC9i2JSHbWdKFlti6Zqxax2SoNt7GnyQ7cnJ5cT6ZJPFsh8ULKZYJehMCo2GsdMB71o1K6Qrt5qpxwqRUFTmpaciHLzNowl7lFU0dIVM9HTjnp8m_Qqxd12AXmba6D0NJxr6gqqLjL-chztP4e5aPog-im0_jYeJzOv7g3HcLszkQuGOKCSXODXOjDYEX22HbeeItAdrwy3bZSVIQGbcNbhGpF-J_svYf0qBMKg-uSii22DotnGoShrJDo4Pbheystq9_gmrJ3XP74-Iv34DPdtcDhfegtn57DAbpHS3cI64O_2WFcBP8AeXsPIA |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dT9swED8xkLa9TDDG6GDMSLymTZ2L6-wNVUMdo30YIPFm2Y4rBY0UsSLtaX_77hKniAcE2luU-JTEd77Pn88AR0NbDudY6iQNhU3Q0ZVNpU8KiwE1NzwJDdpipiaXeHqVX63BuNsLw7DKqPtbnd5o63hnEGdzcFtVg3NyVsg9lFxG5mpa9go2MM9GjOvr_33AeagMWxyj0gkPf9jGM7juc4KTwlqGeOmm2SniUwbqKQe0MUQnm_AuepDiuP3ILVgL9Xt4PY018m24mzLG7ufsWIQ_EeVai3g0t6jokvzlGyt4X4ngBKwYijYBW3kRu6z-_irGZN2SiGMXTQ9aYetSuGoRW63ycBs7mnyAy5NvF-NJEk9WSDwqtUzIh0CKiX1RBIpG_ahULi_cPNUOXWoxpylNS4mqHFob5iqzZOgYh-rlyGmnXLYD6_WiDrsgvM2KgIVy0muuCWrpMjnykmy_J-nIe4DddBof247z6Re_TIcvuzaRC4a5YNLMEBd60F-R3bZ9N54jUB2vTLeplNSgIcvwHKFeET6SvJeQHnZCYWhVcqnF1mFxz4MokEVF7m0PPrbSsvoNWXDuTqpP___iL_BmcjE9M2ffZz_24C0_aSHE-7C-vLsPn8lRWrqDZiH8A8ezD-s |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MicroRNA+expression+profile+in+plasma+from+type+1+diabetic+patients%3A+Case-control+study+and+bioinformatic+analysis&rft.jtitle=Diabetes+research+and+clinical+practice&rft.au=Assmann%2C+Ta%C3%ADs+S.&rft.au=Recamonde-Mendoza%2C+Mariana&rft.au=Pu%C3%B1ales%2C+M%C3%A1rcia&rft.au=Tschiedel%2C+Baldu%C3%ADno&rft.date=2018-07-01&rft.pub=Elsevier+B.V&rft.issn=0168-8227&rft.eissn=1872-8227&rft.volume=141&rft.spage=35&rft.epage=46&rft_id=info:doi/10.1016%2Fj.diabres.2018.03.044&rft.externalDocID=S0168822717320363 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-8227&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-8227&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-8227&client=summon |