Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold

• Published in: Biomaterials Vol. 32; no. 21; pp. 4816 - 4829
• Main Authors: Sharifpoor, Soroor, Simmons, Craig A, Labow, Rosalind S, Paul Santerre, J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2011
• Subjects: Actins - metabolism; Advanced Basic Science; Arterial tissue engineering; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Biomarkers - metabolism; Calcium-Binding Proteins - metabolism; Calponins; Cell Proliferation; Cells, Cultured; Coronary Vessels - anatomy & histology; Dentistry; Humans; Ki-67 Antigen - metabolism; Materials Testing; Microfilament Proteins - metabolism; Muscle, Smooth, Vascular - cytology; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - physiology; Polyurethane; Polyurethanes - chemistry; Polyurethanes - metabolism; Scaffold; Smooth muscle cell; Soft tissue biomechanics; Stress, Mechanical; Tensile Strength; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Smooth muscle cell; Cell proliferation; Arterial tissue engineering; Scaffold; Soft tissue biomechanics; Polyurethane

Abstract There are few synthetic elastomeric biomaterials that simultaneously provide the required biological conditioning and the ability to translate biomechanical stimuli to vascular smooth muscle cells (VSMCs). Biomechanical stresses are important physiological elements that regulate VSMC functi...