A clinical research study on the respective relationships between visfatin and human fetuin A and pregnancy outcomes in gestational diabetes mellitus

• Published in: Taiwanese journal of obstetrics & gynecology Vol. 58; no. 6; pp. 808 - 813
• Main Authors: Lu, Dan, Yang, Meng, Yao, Yanjiao, Xie, Yanyan
• Format: Journal Article
• Language: English
• Published: China (Republic : 1949- ) Elsevier B.V 01.11.2019; Elsevier
• Subjects: Adult; alpha-2-HS-Glycoprotein - metabolism; Biomarkers - metabolism; Diabetes, Gestational - metabolism; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood - metabolism; Gestational diabetes mellitus (GDM); Human fetuin A (AHSG); Humans; Immunohistochemistry; Infant, Newborn; Maternal and foetal adverse outcome; Nicotinamide Phosphoribosyltransferase - metabolism; Placenta - metabolism; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Retrospective Studies; Visfatin (VF); Gestational diabetes mellitus (GDM); Maternal and foetal adverse outcome; Visfatin (VF); Human fetuin A (AHSG)
• ISSN: 1028-4559; 1875-6263
• DOI: 10.1016/j.tjog.2019.09.015

The aim was to determine the role of visfatin (VF) and human fetuin A (AHSG) in the development of gestational diabetes mellitus (GDM) and to explore the association between these variables and adverse outcomes. We carried out our study on 68 cases of GDM pregnant women and 42 cases of healthy pregnant women, including 56 cases with diet control and 12 cases with insulin treatment. Enzyme-linked immunoassay (ELISA) was used to test the expression levels of VF and AHSG in maternal and umbilical cord serum. Immunohistochemistry (ICH) was used to test the expression level of the VF protein in placental tissue. The expression levels of VF and AHSG in maternal and umbilical cord serum and the expression level of VF in placental tissue in GDM pregnant women were higher than those in healthy pregnant women. The incidence of adverse outcomes in the GDM pregnant women was higher than that in healthy pregnant women, and these differences were statistically significant (P < 0.05). Those who had higher expression levels of VF or AHSG had a higher incidence of adverse outcomes (P < 0.05). The expression of VF and AHSG may participate in the development of GDM. A test of VF and AHSG in GDM pregnant women may have some predictive value for the occurrence of adverse outcomes.