Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis

• Published in: Cell host & microbe Vol. 6; no. 1; pp. 91 - 98
• Main Authors: Kallewaard, Nicole L, Zhang, Lili, Chen, Jin-Wen, Guttenberg, Marta, Sanchez, Melissa D, Bergelson, Jeffrey M
• Format: Journal Article
• Language: English
• Published: United States 23.07.2009
• Subjects: Animals; Cells, Cultured; Constitutive Androstane Receptor; Coxsackievirus Infections - prevention & control; Gene Deletion; Heart - virology; Mice; Mice, Knockout; Myocarditis - prevention & control; Myocarditis - virology; Myocardium - pathology; Pancreas - pathology; Pancreas - virology; Pancreatitis - prevention & control; Pancreatitis - virology; Receptors, Cytoplasmic and Nuclear - genetics

In cultured cells, infection by group B coxsackievirus (CVB) is mediated by the coxsackievirus and adenovirus receptor (CAR), but the importance of this molecule in CVB-induced disease has not been determined. We generated mice with tissue-specific ablation of CAR within each of two major CVB target...