Effects of nalidixic acid on hamster knee cartilage morphology and synovial fluid composition

• Published in: Toxicologic pathology Vol. 27; no. 4; p. 421
• Main Authors: Burkhardt, J E, Eskra, J D, Clemo, F A, Otterness, I G
• Format: Journal Article
• Language: English
• Published: United States 01.07.1999
• Subjects: Animals; Anti-Infective Agents - toxicity; Cartilage, Articular - drug effects; Cartilage, Articular - pathology; Cricetinae; Female; Histocytochemistry; Hyaluronic Acid - analysis; Hydroxyproline - analysis; Injections, Intraperitoneal; Knee Joint - drug effects; Knee Joint - pathology; Mesocricetus; Nalidixic Acid - toxicity; Proline - analysis; Proteoglycans - analysis; Synovial Fluid - chemistry; Synovial Fluid - drug effects

Quinolone-induced changes were studied in the knee joints of 4-wk-old female hamsters given intraperitoneal doses of either nalidixic acid (400 mg/kg body weight) or vehicle on days 0 and 1. After euthanasia on day 4, synovial fluid was collected for cytologic evaluation and for analysis of concentr...