Medulloblastoma Associated with Down Syndrome: From a Rare Event Leading to a Pathogenic Hypothesis

• Published in: Diagnostics (Basel) Vol. 11; no. 2; p. 254
• Main Authors: Boni, Alessandra, Ranalli, Marco, Del Baldo, Giada, Carta, Roberto, Lodi, Mariachiara, Agolini, Emanuele, Rinelli, Martina, Valentini, Diletta, Rossi, Sabrina, Alesi, Viola, Cacchione, Antonella, Miele, Evelina, Alessi, Iside, Caroleo, Anna Maria, Colafati, Giovanna Stefania, De Ioris, Maria Antonietta, Boccuto, Luigi, Balducci, Mario, Carai, Andrea, Mastronuzzi, Angela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.02.2021; MDPI
• Subjects: Brain cancer; brain tumor; cancer predisposition syndrome; Case Report; Chromosomes; Cloning; Cognitive ability; Deoxyribonucleic acid; DNA; DNA methylation; Down syndrome; Genes; Hearing loss; Kinases; Leukemia; Magnetic resonance imaging; medulloblastoma; Mutation; Nervous system; Patients; Pediatrics; Population; Proteins; Tumors; brain tumor; Down syndrome; medulloblastoma; cancer predisposition syndrome

Down syndrome (DS) is the most common chromosome abnormality with a unique cancer predisposition syndrome pattern: a higher risk to develop acute leukemia and a lower incidence of solid tumors. In particular, brain tumors are rarely reported in the DS population, and biological behavior and natural...